(+/-)-3-(Ethoxycarbonyl)-5-oxo-3-pyrrolidineacetic acid | 77480-31-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (+/-)-3-(Ethoxycarbonyl)-5-oxo-3-pyrrolidineacetic acid
• 英文别名: 3-(Carboethoxy)-5-oxo-3-pyrrolidineacetic Acid；3-carboxymethyl-5-oxo-pyrrolidine-3-carboxylic acid ethyl ester；2-(3-Ethoxycarbonyl-5-oxopyrrolidin-3-yl)acetic acid
• CAS: 77480-31-0
• 化学式: C₉H₁₃NO₅
• 分子量: 215.206
• InChiKey: JATVNOIBFSCVCJ-UHFFFAOYSA-N

物化性质

• 熔点：
  28.5 °C(Solv: ethyl acetate (141-78-6))
• 沸点：
  458.1±30.0 °C(Predicted)
• 密度：
  1.296±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.2
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  92.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (+/-)-3-(Ethoxycarbonyl)-5-oxo-3-pyrrolidineacetic acid 生成 2,7-二氮杂-螺[4.4]壬烷-1,3,8-三酮
  参考文献：
  名称：

  Absolute configuration of 2,7-diazaspiro[4,4]nonane. A reassignment

  摘要：

  DOI：

  10.1021/jo00326a031
• 作为产物：
  描述：

  2-氰基琥珀酸二乙酯 在 T-1 Raney Nickel sodium hydroxide 、 氢气 、 sodium hydride 作用下， 以 sodium hydroxide 、 乙醇 为溶剂， 30.0~70.0 ℃ 、10.34 MPa 条件下， 反应 76.5h， 生成 (+/-)-3-(Ethoxycarbonyl)-5-oxo-3-pyrrolidineacetic acid
  参考文献：
  名称：

  Absolute configuration of 2,7-diazaspiro[4,4]nonane. A reassignment

  摘要：

  DOI：

  10.1021/jo00326a031

文献信息

• 7-Substituted-6-fluoro-8-substituted-1,4-dihydro-1-methylamino-4-oxo-3-quinolinecarboxylic acids; 7-substituted-6-fluoro-1,4-dihydro-1-methylamino-4-oxo-3-naphthyridine carboxylic acids; derivatives thereof; and processes for producing the compounds
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0169710A2

  公开（公告）日：1986-01-29

  Novel 1-amino-naphthyridine- and quinoline-carboxylic acids of formula wherein Z is as antibacterial agents are described as well as methods for their manufacture and formulations comprising the compounds.

  式中的新型 1-氨基萘啶和喹啉羧酸 其中 Z 为 描述了作为抗菌剂的新型 1-氨基萘啶和喹啉羧酸及其制造方法和包含这些化合物的制剂。
• Substituted-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acids; substituted-5-amino-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acids; substituted-5-amino-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids; derivatives thereof; pharmaceutical compositions comprising the compounds; and processes for producing the compounds
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0172651A1

  公开（公告）日：1986-02-26

  Novel naphthyridine-, quinoline- and benzoxazine carboxylic acids of formula or as antibacterial agents are described as well as methods for their manufacture and formulation. Also disclosed are certain novel intermediates used in the manufacture of the antibacterial agents.

  描述了新颖的式或作为抗菌剂的萘啶、喹啉和苯并噁嗪羧酸及其制造和配制方法。 此外，还公开了用于制造抗菌剂的某些新型中间体。
• -9-fluoro-6,7-dihydro-5-methyl-1-oxo-8-substituted-1H,5H, benzo(ij)-quinoziline-2-carboxylic acids; their derivatives; and processes for producing the compounds
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0174077A1

  公开（公告）日：1986-03-12

  Novel 10-amino-9-fluoro- and 9-fluoro-6, 7-dihydro-5-methyhl-oxo-8-(heterocycle1)1H,5H-benzo(ij) quinoziline-2-carboxylic acids of formula as antibacterial agents are described as well as methods for their manufacture and fomulations. wherein Z is

  描述了作为抗菌剂的新型 10-氨基-9-氟-和 9-氟-6，7-二氢-5-甲基-氧代-8-(杂环1)1H，5H-苯并(ij)喹嗪-2-羧酸，以及它们的制造和制剂方法。 其中 Z 是
• Substituted-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acids, derivatives thereof, pharmaceutical compositions comprising the compounds, and processes for producing the compounds
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0265230A1

  公开（公告）日：1988-04-27

  Novel naphthyridine-, quinoline- and benzoxazinecarboxylic acids of formula in which Z is are disclosed. The compounds are useful as antibacterial agents. Also disclosed is a process for producing the compounds and a pharmaceutical composition comprising the compounds.

  新颖的萘啶、喹啉和苯并噁嗪羧酸，其式为 其中 Z 为 的新型萘啶-喹啉-和苯并噁嗪羧酸。这些化合物可用作抗菌剂。还公开了生产这些化合物的工艺和包含这些化合物的药物组合物。
• Kajtar, Marton; Hollosi, Miklos; Kinsky, Klaus, Collection of Czechoslovak Chemical Communications, 1982, vol. 47, # 3, p. 936 - 949
  作者：Kajtar, Marton、Hollosi, Miklos、Kinsky, Klaus、Majer, Zsuzsanna

  DOI：——

  日期：——