4-(3-Nitro-phenyl)-buttersaeure | 1823-15-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(3-Nitro-phenyl)-buttersaeure
• 英文别名: Benzenebutanoic acid, 3-nitro-；4-(3-nitrophenyl)butanoic acid
• CAS: 1823-15-0
• 化学式: C₁₀H₁₁NO₄
• 分子量: 209.202
• InChiKey: ZEUMMKNNXDUFAR-UHFFFAOYSA-N

物化性质

• 熔点：
  125 °C
• 沸点：
  390.7±17.0 °C(Predicted)
• 密度：
  1.293±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  83.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-(3-Nitro-phenyl)-buttersaeure 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 反应 12.0h， 以99%的产率得到4-(3-aminophenyl)butanoic acid
  参考文献：
  名称：

  Polyiodinated Triglyceride Analogs as Potential Computed Tomography Imaging Agents for the Liver

  摘要：

  A series of glyceryl 2-oleoyl 1,3-bis[omega-(3-amino-2,4,6-triiodophenyl]) alkanoates was synthesized, radioiodinated with iodine-125, emulsified, and evaluated for their ability to selectively localize in the liver for potential use as hepatographic agents in computed tomography. All seven analogs displayed rapid liver uptake wherein between 65 and 78% of the injected dose accumulated in the liver by 30 min. Liver values ranged from 46 to 93% 3 h after injection which corresponded to liver to blood ratios ranging from 21 to 450. Moreover, subsequent elimination of radioactivity from the liver was nearly linear with respect to alkyl chain length. Analogs with longer alkyl chain length were eliminated from the liver more rapidly than their shorter chain counterparts. Because of their biochemical similarities to naturally occurring triglycerides, these novel analogs may prove useful not only for high-resolution anatomic imaging of focal liver lesions, but also for evaluating a variety of diffuse diseases known to affect hepatic function and biochemistry.

  DOI：

  10.1021/jm00004a010
• 作为产物：
  描述：

  3-(3-nitrophenyl)-1-propionitrile 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 反应 1.0h， 以76%的产率得到4-(3-Nitro-phenyl)-buttersaeure
  参考文献：
  名称：

  Polyiodinated Triglyceride Analogs as Potential Computed Tomography Imaging Agents for the Liver

  摘要：

  A series of glyceryl 2-oleoyl 1,3-bis[omega-(3-amino-2,4,6-triiodophenyl]) alkanoates was synthesized, radioiodinated with iodine-125, emulsified, and evaluated for their ability to selectively localize in the liver for potential use as hepatographic agents in computed tomography. All seven analogs displayed rapid liver uptake wherein between 65 and 78% of the injected dose accumulated in the liver by 30 min. Liver values ranged from 46 to 93% 3 h after injection which corresponded to liver to blood ratios ranging from 21 to 450. Moreover, subsequent elimination of radioactivity from the liver was nearly linear with respect to alkyl chain length. Analogs with longer alkyl chain length were eliminated from the liver more rapidly than their shorter chain counterparts. Because of their biochemical similarities to naturally occurring triglycerides, these novel analogs may prove useful not only for high-resolution anatomic imaging of focal liver lesions, but also for evaluating a variety of diffuse diseases known to affect hepatic function and biochemistry.

  DOI：

  10.1021/jm00004a010

文献信息

• Experiments on the <i>Chaperon</i> Effect in the Nitration of Aromatics
  作者：Paolo Strazzolini、Angelo G. Giumanini、Antonio Runcio、Massimo Scuccato

  DOI：10.1021/jo9709763

  日期：1998.2.1

  A nitro group may be effectively delivered to the ortho position of alkylbenzenes, provided that a suitable chaperon function is located in alpha-position and a dilute solution of HNO3 in CH2Cl2 is used. The carbonyl function of an aldehyde or ketone is the best choice, but a carboxyl, alkoxycarbonyl, and amide groups all work well. The ether function showed a less pronounced or tho orientation effect, whereas the hydroxyl group was too prone to oxidation. Side reactions were minimal under the conditions employed. A para chaperon effect was seemingly at work in the CH2Cl2 nitration of benzenepropanenitrile. All the results mere compared with the corresponding classical nitration in H2SO4.
• Pyrazolo magenta couplers used in silver halide photography
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：EP0119860B1

  公开（公告）日：1989-10-25
• PROMOTER SEQUENCES DERIVED FROM FUSARIUM VENENATUM AND USES THEREOF
  申请人：Novozymes Biotech, Inc.

  公开号：EP1194572A2

  公开（公告）日：2002-04-10
• EP1663204B1
  申请人：——

  公开号：EP1663204B1

  公开（公告）日：2014-05-07
• PROCESS FOR REMOVING INK FROM PRINTED SUBSTRATE
  申请人：Nauka Krzysztof

  公开号：US20110073134A1

  公开（公告）日：2011-03-31

  A process for removing ink from a printed media substrate. Such process includes the step of providing a media substrate including an ink printed image wherein the ink composition or the media substrate contains photolabile entities. Then the process includes the step of applying UV light on the printed substrate wherein the emitted UV light has a wavelength value which is below the threshold wavelength of the photolabile entities.