6,8-二氟-1,2-二氢萘 | 939760-86-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 6,8-二氟-1,2-二氢萘
• 英文名称: 6,8-Difluoro-1,2-dihydronaphthalene
• CAS: 939760-86-8
• 化学式: C₁₀H₈F₂
• mdl: MFCD08544535
• 分子量: 166.17
• InChiKey: SQVICXDNASSTAD-UHFFFAOYSA-N

物化性质

• 沸点：
  197.1±40.0 °C(Predicted)
• 密度：
  1.204±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6,8-二氟-1,2-二氢萘 在 lithium aluminium tetrahydride 、 间氯过氧苯甲酸 作用下， 以 四氢呋喃 、 氯仿 为溶剂， 生成 5,7-difluorotetralol
  参考文献：
  名称：

  Kinetic enzymatic resolution of β-tetralols

  摘要：

  Several substituted beta-tetralols 1a-e and beta-tetralol 2 were successfully resolved using porcine pancreatin in hydrocarbon solvents. All attempts to resolve the substituted beta-tetralols by diasteromeric derivatization have failed. The absolute configuration of the products was established by literature precedence.

  DOI：

  10.1016/0957-4166(95)00180-w
• 作为产物：
  描述：

  5,7-二氟-3,4-二氢-2H-萘-1-酮 在 sodium tetrahydroborate 、 对甲苯磺酸 作用下， 以 甲醇 、 苯 为溶剂， 生成 6,8-二氟-1,2-二氢萘
  参考文献：
  名称：

  Kinetic enzymatic resolution of β-tetralols

  摘要：

  Several substituted beta-tetralols 1a-e and beta-tetralol 2 were successfully resolved using porcine pancreatin in hydrocarbon solvents. All attempts to resolve the substituted beta-tetralols by diasteromeric derivatization have failed. The absolute configuration of the products was established by literature precedence.

  DOI：

  10.1016/0957-4166(95)00180-w

文献信息

• Treatment of Post-Traumatic Stress Disorder
  申请人：Woiwode Tom

  公开号：US20090054403A1

  公开（公告）日：2009-02-26

  Provided are methods of treating a patient diagnosed with post-traumatic stress disorder, by administering to the patient a therapeutically effective amount of Compound A. Also provided are methods of improving resilience in a patient by administering a therapeutically effective amount of Compound A. Also provided are methods of diagnosing post-traumatic stress disorder in a patient by administering to the patient a therapeutically effective amount of Compound A and assessing at least one of sign, symptom, or symptom cluster of post-traumatic stress disorder; and diagnosing post-traumatic stress disorder in the patient if the Compound A reduces at least one of sign, symptom, and symptom cluster of post-traumatic stress disorder.

  提供了一种治疗创伤后应激障碍患者的方法，即向患者施用治疗有效量的A化合物。此外，还提供了一种通过向患者施用治疗有效量的A化合物来提高患者适应力的方法。还提供了一种通过向患者施用治疗有效量的A化合物并评估创伤后应激障碍的至少一个体征、症状或症状群，来诊断患者是否患有创伤后应激障碍的方法；如果A化合物减轻了创伤后应激障碍的至少一个体征、症状或症状群，则诊断患者患有创伤后应激障碍。
• Kinetic enzymatic resolution of β-tetralols
  作者：Gregory R. Martinez

  DOI：10.1016/0957-4166(95)00180-w

  日期：1995.7

  Several substituted beta-tetralols 1a-e and beta-tetralol 2 were successfully resolved using porcine pancreatin in hydrocarbon solvents. All attempts to resolve the substituted beta-tetralols by diasteromeric derivatization have failed. The absolute configuration of the products was established by literature precedence.