4-Chlorphenylacetyl-N-acetylamid | 115601-10-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-Chlorphenylacetyl-N-acetylamid
• 英文别名: N-acetyl-2-(4-chlorophenyl)acetamide
• CAS: 115601-10-0
• 化学式: C₁₀H₁₀ClNO₂
• 分子量: 211.648
• InChiKey: AUYFPVNPTSAKQY-UHFFFAOYSA-N

物化性质

• 沸点：
  372.1±25.0 °C(Predicted)
• 密度：
  1.242±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  丁基铵乙酸盐 、 对氯苯乙腈 在 三氟甲磺酸酐 、 水 、 碳酸氢钠 作用下， 反应 1.08h， 以83%的产率得到4-Chlorphenylacetyl-N-acetylamid
  参考文献：
  名称：

  n-Butylammonium carboxylates/Tf2O: ionic liquid based systems for the synthesis of unsymmetrical imides via a Ritter-type reaction

  摘要：

  We have developed a new method for the preparation of unsymmetrical imides using liquid carboxylate salts via a Ritter-type process. The reactions were carried out with nitriles and n-butylammonium carboxylates as ionic liquids in the presence of triflic anhydride (Tf2O) as the promoter. Mild reaction conditions, simplicity of the procedure, and proton-free conditions are the main advantages of this procedure. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.03.121

文献信息

• N-(alpha-alkylbenzylidene)-alpha-phenylalkylamine, its use and process for producing the same and process for producing intermediate therefor
  申请人：SUMITOMO CHEMICAL COMPANY LIMITED

  公开号：EP0735018A1

  公开（公告）日：1996-10-02

  There is disclosed an N-(α-alkylbenzylidene)-α-phenylalkylamine represented by the general formula (1): wherein R1 represents a lower alkyl group, R2 represents a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group and X represents a halogen atom or a lower alkoxy group, its use and a process for producing the same and processes for producing intermediates therefor.

  本发明公开了通式(1)代表的N-(α-烷基亚苄基)-α-苯基烷基胺： 其中 R1 代表低级烷基，R2 代表氢原子、卤素原子、低级烷基或低级烷氧基，X 代表卤素原子或低级烷氧基。
• Kathodische Reduktion von S�ureaziden Elektrolytische Untersuchungen an Vinylaziden, 8. Mitt.
  作者：Dierk Knittel

  DOI：10.1007/bf00810418

  日期：1988.4
• US5739401A
  申请人：——

  公开号：US5739401A

  公开（公告）日：1998-04-14
• US6093851A
  申请人：——

  公开号：US6093851A

  公开（公告）日：2000-07-25
• n-Butylammonium carboxylates/Tf2O: ionic liquid based systems for the synthesis of unsymmetrical imides via a Ritter-type reaction
  作者：Mohammad Mehdi Khodaei、Ehsan Nazari

  DOI：10.1016/j.tetlet.2012.03.121

  日期：2012.6

  We have developed a new method for the preparation of unsymmetrical imides using liquid carboxylate salts via a Ritter-type process. The reactions were carried out with nitriles and n-butylammonium carboxylates as ionic liquids in the presence of triflic anhydride (Tf2O) as the promoter. Mild reaction conditions, simplicity of the procedure, and proton-free conditions are the main advantages of this procedure. (C) 2012 Elsevier Ltd. All rights reserved.