7-(4-bromophenyl)-5-(4-chlorophenyl)-3-(4-methoxyphenyl)-2-sulfanylidene-1H-pyrido[2,3-d]pyrimidin-4-one | 400031-96-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 7-(4-bromophenyl)-5-(4-chlorophenyl)-3-(4-methoxyphenyl)-2-sulfanylidene-1H-pyrido[2,3-d]pyrimidin-4-one
• CAS: 400031-96-1
• 化学式: C₂₆H₁₇BrClN₃O₂S
• 分子量: 550.863
• InChiKey: RPYULCHYFKUUHN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  34
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  86.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  7-(4-bromophenyl)-5-(4-chlorophenyl)-3-(4-methoxyphenyl)-2-sulfanylidene-1H-pyrido[2,3-d]pyrimidin-4-one 在 ammonium sulfate 作用下， 以 甲苯 为溶剂， 反应 14.0h， 生成
  参考文献：
  名称：

  SYNTHESIS OF SOME 2-THIOXOPYRIDO[2,3-d]PYRIMIDINE RIBOFURANOSIDES AND THEIR ANTIMICROBIAL ACTIVITY

  摘要：

  2-Thioxo-3,5,7-trisubstituted-1-[2',3',5'-tri-O-benzoyl-beta -D-ribofuranosyl]pyrido [2,3-d]pyrimidin-4(1H)-ones have been prepared by the condensation of trimethylsilyl derivative of w2-thioxo-3,5,7-trisubstituted pyrido[2,3-d]pyrimidin-4(IH)-ones with P-D-ribofuranose 1-acetate-2,3,5-tribenzoate in 65%-78% yield. The structure of the synthesized ribofuranosides and their precursors have been established by JR, H-1 NMR and elemental analysis. These derivatives, have been screened for their antimicrobial activity.

  DOI：

  10.1080/10426500108040270
• 作为产物：
  描述：

  1-(4-溴苯基)-3-(4-氯苯基)-2-丙烯-1-酮 在 乙酸铵 、 氢氧化钾 作用下， 以 二苯醚 、 乙醇 为溶剂， 生成 7-(4-bromophenyl)-5-(4-chlorophenyl)-3-(4-methoxyphenyl)-2-sulfanylidene-1H-pyrido[2,3-d]pyrimidin-4-one
  参考文献：
  名称：

  SYNTHESIS OF SOME 2-THIOXOPYRIDO[2,3-d]PYRIMIDINE RIBOFURANOSIDES AND THEIR ANTIMICROBIAL ACTIVITY

  摘要：

  2-Thioxo-3,5,7-trisubstituted-1-[2',3',5'-tri-O-benzoyl-beta -D-ribofuranosyl]pyrido [2,3-d]pyrimidin-4(1H)-ones have been prepared by the condensation of trimethylsilyl derivative of w2-thioxo-3,5,7-trisubstituted pyrido[2,3-d]pyrimidin-4(IH)-ones with P-D-ribofuranose 1-acetate-2,3,5-tribenzoate in 65%-78% yield. The structure of the synthesized ribofuranosides and their precursors have been established by JR, H-1 NMR and elemental analysis. These derivatives, have been screened for their antimicrobial activity.

  DOI：

  10.1080/10426500108040270