3-dimethylamino-3-phenylpropionic acid | 6098-50-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 苯丙酸
• 英文名称: 3-dimethylamino-3-phenylpropionic acid
• 英文别名: (+/-)-3-dimethylamino-3-phenyl-propionic acid；3-dimethylamino-3-phenyl-propionic acid；(+/-)-3-Dimethylamino-3-phenyl-propionsaeure；β-Dimethylamino-β-phenyl-propionsaeure；β-Dimethylamino-hydrozimtsaeure；3-Dimethylamino-3-phenyl-propionsaeure；3-(dimethylamino)-3-phenylpropanoic acid
• CAS: 6098-50-6
• 化学式: C₁₁H₁₅NO₂
• 分子量: 193.246
• InChiKey: JTKDHNKYUPVADI-UHFFFAOYSA-N

物化性质

• 沸点：
  283.4±28.0 °C(Predicted)
• 密度：
  1.108±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-dimethylamino-3-phenylpropionic acid 在 sodium tetrahydroborate 作用下， 以 四氢呋喃 、 乙醇 、 丙酮 为溶剂， 生成 (+)-3-N,N-二甲基氨基-3-苯基丙醇L-酒石酸盐
  参考文献：
  名称：

  [EN] PROCESSES FOR THE PREPARATION OF (+)-N,N-DIMETHYL-2-[1-(NAPHTHALENYLOXY) ETHYL] BENZENE METHANAMINE AND INTERMEDIATES THEREOF
  [FR] PROCÉDÉS POUR LA PRÉPARATION DE (+)-N,N-DIMÉTHYL-2-[1-(NAPHTALÉNYLOXY)ÉTHYL]BENZÈNE-MÉTHANAMINE ET INTERMÉDIAIRES DE CELLE-CI

  摘要：

  本发明涉及用于制备S(+) -N,N-二甲基-2-[1-(萘氧基)乙基]苯甲胺及其中间体的过程。更具体地，本发明涉及制备化合物3(S)-(+)-N,N-二甲基氨基-3-苯基丙醇，该化合物在合成药用活性化合物中作为中间体时有用。

  公开号：

  WO2011161690A1
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 diluted acid 作用下， 生成 3-dimethylamino-3-phenylpropionic acid
  参考文献：
  名称：

  Winterstein; Guyer, Hoppe-Seyler's Zeitschrift fur Physiologische Chemie, 1923, vol. 128, p. 204,205, 208

  摘要：

  DOI：

文献信息

• [EN] NANOMATERIAL COMPOSITIONS, SYNTHESIS, AND ASSEMBLY<br/>[FR] COMPOSITIONS DE NANOMATÉRIAU, SYNTHÈSE ET ASSEMBLAGE
  申请人：RHODE ISLAND HOSPITAL

  公开号：WO2016081522A1

  公开（公告）日：2016-05-26

  Compositions or an assembly of a series of biomimetic compounds include chemical structures that mimic or structurally resemble a nucleic acid base pair. Complexes of nanotubes and agents are useful to deliver agents into the cells or bodily tissues of individuals for therapeutic and diagnostic purposes. Exemplary compounds include those of Formula (I), (III), (V) or (VII), or of Formula (II), (IV), (VI) or (VIII).

  一系列仿生化合物的组成或装配包括模拟或在结构上类似于核酸碱基对的化学结构。纳米管和试剂的复合物可用于将试剂输送到个体的细胞或身体组织中，用于治疗和诊断目的。示例化合物包括Formula (I)、(III)、(V)或(VII)的化合物，或Formula (II)、(IV)、(VI)或(VIII)的化合物。
• Taxines from the needles of Taxus wallichiana
  作者：Jeevan Kumar Prasain、Piotr Stefanowicz、Taira Kiyota、Farida Habeichi、Yasuo Konishi

  DOI：10.1016/s0031-9422(01)00305-3

  日期：2001.12

  O-(3'-dimethylamino-3'-phenylpropionyl) taxinine M (1) together with two known compounds 7-O-acetyltaxine A (2) and 2 alpha-acetoxy-2' beta-deacetylaustrospicatine (3) were isolated from the needles of the Himalayan yew, Taxus wallichiana Zucc. Their structures were elucidated on the basis of the NMR spectral data, ESI-MS/MS analysis and chemical methods. Compounds 1 and 3 showed moderate cytotoxic activity

  紫杉碱、5 α O-(3'-二甲氨基-3'-苯基丙酰基) 紫杉碱 M (1) 以及两种已知化合物 7-O-乙酰紫杉碱 A (2) 和 2 α-乙酰氧基-2' β-脱乙酰基紫杉碱 (3 ) 是从喜马拉雅红豆杉的针叶中分离出来的，Taxus wallichiana Zucc。基于NMR光谱数据、ESI-MS/MS分析和化学方法阐明了它们的结构。化合物 1 和 3 在体外对肺癌细胞系 A549 显示出中等的细胞毒活性。
• 1-phenyl-3-naphthalenyloxypropanamines and their use as selective
  申请人：Eli Lilly and Company

  公开号：US05135947A1

  公开（公告）日：1992-08-04

  The present invention provides 1-phenyl-3-naphthalenyloxypropanamines which are selective inhibitors of serotonin uptake.

  本发明提供了1-苯基-3-萘氧基丙胺类化合物，它们是选择性的血清素摄取抑制剂。
• Ink jet ink composition and method for security marking
  申请人：Videojet Technologies Inc.

  公开号：US20040220298A1

  公开（公告）日：2004-11-04

  Disclosed is an ink composition suitable for ink jet printing comprising a luminescent compound, a solvent, and an energy active compound, and optionally a non-luminescent colorant. The energy active compound, when exposed to energy, generates one or more active species that can react with the luminescent compound to alter one or more of the characteristics of the luminescent compound. The luminescent compound can be colored or colorless. Also disclosed is a method for marking substrates comprising providing a mark comprising a luminescent compound and an energy active compound. Further disclosed is a jet ink composition suitable for printing on substrates authentication or security marks which can be rendered unreadable. The luminescence of the mark is quenched and the visible color is changed when irradiated with a light.

  本发明公开了一种适用于喷墨打印的油墨组合物，该组合物包含一种发光化合物、一种溶剂和一种能量活性化合物，以及可选的一种非发光着色剂。能量活性化合物在暴露于能量时，会产生一种或多种活性物质，这些活性物质可与发光化合物发生反应，从而改变发光化合物的一种或多种特性。发光化合物可以是有色或无色的。本发明还公开了一种标记基底的方法，包括提供一种包含发光化合物和能量活性化合物的标记。进一步公开的是一种喷墨组合物，适用于在基底上打印认证或防伪标志，可使其变得不可读。当用灯光照射时，标记的发光被熄灭，可见光颜色发生变化。
• Persistent Pneumomediastinum and Dermatomyositis: A Case Report and Review of the Literature
  作者：V. A. Barvaux、X. Van Mullem、Th. Pieters、F. A. Houssiau

  DOI：10.1007/pl00011208

  日期：2001.9

  We describe a 42-year-old man with dermatomyositis and interstitial lung disease who presented with anterior neck pain and dyspnoea. Chest radiographs showed subcutaneous emphysema, pneumomediastinum and diffuse reticulonodular infiltration in both lungs. After the administration of high doses of prednisolone, an improvement of pulmonary function and respiratory symptoms was observed but the pneumomediastinum persists 12 months after diagnosis, and without any complication. We review the cases that have been reported thus far of pneumomediastinum associated with dermatomyositis and discuss the possible mechanisms involved. We conclude that pneumomediastinum is not an uncommon complication of dermatomyositis and that its aetiopathogenesis remains very unclear.