1-(4-bromo-benzyloxy)-4-(4-methoxyphenyl)-butane | 1018349-43-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(4-bromo-benzyloxy)-4-(4-methoxyphenyl)-butane
• 英文别名: 1-Bromo-4-[4-(4-methoxyphenyl)butoxymethyl]benzene
• CAS: 1018349-43-3
• 化学式: C₁₈H₂₁BrO₂
• 分子量: 349.268
• InChiKey: SEXOFJBQVVGAJS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  21
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-((4-bromobenzyl)oxy)-1-methylpyridinium triflate 、 4-(4-甲氧苯基)-1-丁醇 在 magnesium oxide 作用下， 以 various solvent(s) 为溶剂， 反应 24.0h， 以89%的产率得到1-(4-bromo-benzyloxy)-4-(4-methoxyphenyl)-butane
  参考文献：
  名称：

  Stable Oxypyridinium Triflate (OPT) Salts for the Synthesis of Halobenzyl Ethers

  摘要：

  A collection of new oxypyridinium triflate reagents (1a-d) for the synthesis of halobenzyl ethers from alcohols under "mix-and-heat" conditions is described. The reagents are stable organic salts that can be stored indefinitely and handled without special precautions, making them attractive for general use in organic synthesis. Halobenzylation of representative alcohols occurs in good to excellent yield.

  DOI：

  10.1080/00397910701818362

文献信息

• Stable Oxypyridinium Triflate (OPT) Salts for the Synthesis of Halobenzyl Ethers
  作者：Philip A. Albiniak、Shawn M. Amisial、Gregory B. Dudley、Joseph P. Hernandez、Sarah E. House、Margaret E. Matthews、Ernest O. Nwoye、Maureen K. Reilly、Sami F. Tlais

  DOI：10.1080/00397910701818362

  日期：2008.2.13

  A collection of new oxypyridinium triflate reagents (1a-d) for the synthesis of halobenzyl ethers from alcohols under "mix-and-heat" conditions is described. The reagents are stable organic salts that can be stored indefinitely and handled without special precautions, making them attractive for general use in organic synthesis. Halobenzylation of representative alcohols occurs in good to excellent yield.