The present invention relates to bumetanide derivatives of formula (I) as well as pharmaceutical compositions comprising these compounds for use in the treatment or prevention of neurological diseases/disorders involving Na+- K+- 20Γ - cotransporters (NKCCs), such as stroke, traumatic brain injury (TBI), spinal cord injury (SCI), peripheral nerve injury (PNI), brain edema, or glioma, and particularly for use in the treatment or prevention of stroke. The invention likewise relates to a method of treating or preventing a neurological disease or disorder involving an NKCC, such as stroke, TBI, SCI, PNI, brain edema, or glioma, the method comprising administering a compound of formula (I) to a subject in need thereof.
本发明涉及公式(I)的
布美他尼德衍
生物,以及包含这些化合物的制药组合物,用于治疗或预防涉及Na + - K + - 20Γ-共转运体(NKCC)的神经疾病/障碍,例如中风,创伤性脑损伤(TBI),脊髓损伤(SCI),周围神经损伤(
PNI),脑
水肿或胶质瘤,并特别用于治疗或预防中风。本发明还涉及一种治疗或预防涉及NKCC的神经疾病或障碍的方法,例如中风,TBI,SCI,
PNI,脑
水肿或胶质瘤,该方法包括向需要该化合物的受试者施用公式(I)的化合物。