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endo-(5S)-4-methoxycarbonyl-1-azabicyclo<3.3.0>octan-2-one | 119323-31-8

中文名称
——
中文别名
——
英文名称
endo-(5S)-4-methoxycarbonyl-1-azabicyclo<3.3.0>octan-2-one
英文别名
(1S,2S)-2-methoxycarbonyl-5-azabicyclo<3.3.0>octan-4-one;methyl (1S,8S)-3-oxo-1,2,5,6,7,8-hexahydropyrrolizine-1-carboxylate
endo-(5S)-4-methoxycarbonyl-1-azabicyclo<3.3.0>octan-2-one化学式
CAS
119323-31-8
化学式
C9H13NO3
mdl
——
分子量
183.207
InChiKey
SGDJTXAHRAHLTO-BQBZGAKWSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    -0.2
  • 重原子数:
    13
  • 可旋转键数:
    2
  • 环数:
    2.0
  • sp3杂化的碳原子比例:
    0.78
  • 拓扑面积:
    46.6
  • 氢给体数:
    0
  • 氢受体数:
    3

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量
  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

点击查看最新优质反应信息

文献信息

  • Hydrogenation of pyrrolizin-3-ones; new routes to pyrrolizidines
    作者:Xavier L. M. Despinoy、Hamish McNab
    DOI:10.1039/b910199c
    日期:——
    catalysts. Good diastereoselectivity (up to >97:3, depending on catalysts and solvent) can be achieved if the pyrrolizin-3-one is substituted at the 1- (or 7-) position(s), but the selectivity is reduced if both positions are substituted. Subsequent deoxygenation of the pyrrolizidin-3-ones provides concise, diastereoselective routes to the necine bases (±)-heliotridane 5, (±)-isoretronecanol 6 and (±)retronecanol
    在非均相催化剂的存在下,吡咯嗪-3-酮(例如1)可以很容易地氢化成它们的六氢(吡咯并嗪-3-酮)衍生物。如果吡咯烷嗪-3-酮在1-(或7-)位置被取代,则可以实现良好的非对映选择性(取决于催化剂和溶剂,可达> 97:3),但是如果两个位置均被降低,则选择性降低被取代。吡咯嗪3-3-酮的随后脱氧提供了简明的,非对映选择性的途径,从而形成了烟碱(±)-硫代三烷5,(±)-异戊烯醇6和(±)丁烯醇7。
  • Blum, Zoltan; Ekstroem, Mikael; Wistrand, Lars-Goeran, Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry, 1984, vol. 38, # 4, p. 297 - 302
    作者:Blum, Zoltan、Ekstroem, Mikael、Wistrand, Lars-Goeran
    DOI:——
    日期:——
  • Cyclisation at very high temperature. Thermal transformations of N-alkyl and N, N-dialkyl amides of α,β-unsaturated acids into mono- and bicyclic heterocycles under FVT conditions
    作者:Stanisław Leśniak、Ryszard B. Nazarski、Beata Pasternak
    DOI:10.1016/j.tet.2009.06.011
    日期:2009.8
    Cyclisations of N-alkyl and N,N-dialkyl cinnamic amides to the corresponding pyrrolidin-2-ones under the conditions of flash vacuum thermolysis (FVT), are described. It was found that these reactions proceed at 950-1000 degrees C affording in various yields the mixtures of isomeric mono and bicyclic gamma-lactams, which were separated chromatographically and analysed by means of NMR spectroscopy. Two alternative mechanisms for the title process are proposed. (C) 2009 Elsevier Ltd. All rights reserved.
  • Osmium(II)-, Rhenium(I)-, and Tungsten(0)-Promoted Dipolar Cycloaddition Reactions with Pyrroles:  Exploiting the Azomethine Ylide Character of This Heterocycle
    作者:Kevin D. Welch、Philip L. Smith、Andrew P. Keller、William H. Myers、Michal Sabat、W. Dean Harman
    DOI:10.1021/om060586j
    日期:2006.10.1
    Complexes of the form TpRe(CO)(MeIm)(eta(2)-pyr) and TpW(NO)(PMe3)(eta(2)-pyr) (where pyr = 1-methylpyrrole, 2-methylpyrrole, and 2,5-dimethylpyrrole) were prepared and combined with a range of potential dipolarophiles. In several cases a dipolar cycloaddition resulted in the formation of 7-azanorbornene complexes (one crystal structure for each metal is presented), but attempts to develop a general route to the organic bicyclic system were unsuccessful. Using the complex [Os(NH3)(5)(eta(2-)pyrrole)](2+) an organic cycloadduct was successfully prepared with dimethyl fumarate, and this complex was elaborated into advanced synthons to several naturally occurring pyrrolizidines.
  • Coz, Sylvie Le; Mann, Andre; Thareau, Frederic, Heterocycles, 1993, vol. 36, # 9, p. 2073 - 2080
    作者:Coz, Sylvie Le、Mann, Andre、Thareau, Frederic、Taddei, Maurizio
    DOI:——
    日期:——
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同类化合物

颈花脒 罗拉西坦 矛裂碱 甲基六氢-1H-吡咯里嗪-1-羧酸酯 瓶千里光碱N-氧化物 新瓶草千里光碱 异款冬碱 季普拉嗪 四氢-1H-吡咯里嗪-2(3H)-酮 四氢-1H-吡咯烷-7a(5H)-乙酸 四氢-1H-吡咯并吡咯烷-7a(5H)-乙胺二盐酸盐 四氢-1H-吡咯嗪-7a(5h)-乙酸乙酯 响铃豆碱 去甲一叶秋碱 六氢-吡咯嗪-1-酮 六氢-3-(羟甲基)-1H-吡咯里嗪-1,2,7-三醇 六氢-1H-吡咯里嗪-2-羧酸 六氢-1H-吡咯里嗪 六氢-1H-吡咯嗪-7A-甲腈 倒千里光裂醇 二[[(1R,8R)-2,3,5,6,7,8-六氢-1H-吡咯里嗪-1-基]甲基]2,4-二(4-羟基苯基)环丁烷-1,3-二羧酸酯 [(1S,8R)-2,3,5,6,7,8-六氢-1H-吡咯里嗪-1-基]甲醇 [(1S,7R,8R)-7-[(Z)-2-甲基丁-2-烯酰基]氧基-2,3,5,6,7,8-六氢-1H-吡咯里嗪-1-基]甲基 (Z)-2-(羟基甲基)丁-2-烯酸酯 7a-乙氧基-7,7-二甲基六氢-3H-吡咯里嗪-3-酮 7Alpha-双稠吡咯啶-乙酸盐酸盐 7Alpha-双稠吡咯啶-乙腈 7-甲基六氢-1H-吡咯里嗪-1-酮 7,8-二羟基-4'-甲氧基异黄酮 5-甲氧羰基甲基-1-氮杂双环[3.3.0]辛烷 5-氧代六氢-1H-吡咯里嗪-1-甲醛 5-(2-氨基乙基)-1-氮杂双环[3.3.0]辛烷 2,3,5,6,7,8-六氢-1H-吡咯里嗪-1-胺 1-氮杂二环[2.2.1]庚烷,3-(5-异[口噁]唑基)-,外-(9CI) (六氢-1H-吡咯里嗪-7A-基)甲胺 (Z)-2-甲基-2-丁烯酸[(1S,2R,7aS)-六氢-1-羟基甲基-1H-吡咯里嗪-2-基]酯 (Z)-2-甲基-2-丁烯酸[(1S,2R,7aR)-六氢-2beta-羟基-1H-吡咯里嗪-1beta-基]甲基酯 (7aS)-六氢-3H-吡咯里嗪-3-酮 (7aS)-2-甲基四氢-1H-吡咯里嗪-1,3(2H)-二酮 (7R,7aR)-7-异丙基六氢-3H-吡咯里嗪-3-酮 (2S,3S)-2,3-二羟基-2-异丙基丁酸[(1R,7aalpha)-六氢-1H-吡咯里嗪-1-基]甲基酯 (2S,3R)-2,3-二羟基-2-异丙基丁酸[(1R,7aR)-六氢-1H-吡咯里嗪-1-基]甲基酯 (2S,3R)-2,3-二羟基-2-异丙基丁酸 [(1R,7aS)-2,3,5,6,7,7a-六氢-1H-吡咯里嗪-1-基]甲酯 (1S-(1alpha,2alpha,7aalpha))-六氢-2-羟基-2-甲基-1H-吡咯里嗪-1-羧酸甲酯 (1R,8S)-3-氧代-1,2,5,6,7,8-六氢吡咯里嗪e-1-甲醛 (1R,8S)-1-甲基六氢-1H-吡咯嗪 (1R,8R)-7-亚甲基-1,2,3,5,6,8-六氢吡咯里嗪-1-醇 (1R,7aS)-1-[[[(2S,3R)-2,3-二羟基-2-异丙基丁酰基]氧基]甲基]六氢-1H-吡咯里嗪4-氧化物 (1R,7S,8R)-7-(羟基甲基)-2,3,5,6,7,8-六氢-1H-吡咯里嗪-1-醇 (1R,6S,7S,8R)-7-(羟甲基)-2,3,5,6,7,8-六氢-1H-吡咯嗪-1,6-二醇 (1R,2R,3R,7S,8S)-3-(羟基甲基)-2,3,5,6,7,8-六氢-1H-吡咯里嗪-1,2,7-三醇