6-(2,4-二氯苯基)-8-甲氧基-2-(4-(2-二甲氨基乙氧基)-苯基氨基)-吡啶并[2,3-d]嘧啶-7-酮 | 1021302-68-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 6-(2,4-二氯苯基)-8-甲氧基-2-(4-(2-二甲氨基乙氧基)-苯基氨基)-吡啶并[2,3-d]嘧啶-7-酮
• 英文名称: 6-(2,4-Dichlorophenyl)-8-methoxy-2-(4-(2-dimethylaminoethoxy)-phenylamino)-pyrido[2,3-d]pyrimidin-7-one
• 英文别名: 6-(2,4-dichlorophenyl)-8-methoxy-2-(4-(2-dimethylaminoethoxy)phenylamino)pyrido[2,3-d]pyrimidin-7-one；6-(2,4-Dichlorophenyl)-2-[4-[2-(dimethylamino)ethoxy]anilino]-8-methoxypyrido[2,3-d]pyrimidin-7-one
• CAS: 1021302-68-0
• 化学式: C₂₄H₂₃Cl₂N₅O₃
• 分子量: 500.384
• InChiKey: RNSYPBQCXQNRDB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  79.8
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  4-氯-2-甲硫基嘧啶-5-羧酸 在 potassium carbonate 、 (+)-8,8-二氯樟脑磺哑嗪 作用下， 以 1,4-二氧六环 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.67h， 生成 6-(2,4-二氯苯基)-8-甲氧基-2-(4-(2-二甲氨基乙氧基)-苯基氨基)-吡啶并[2,3-d]嘧啶-7-酮
  参考文献：
  名称：

  WO2008/150260

  摘要：

  公开号：

文献信息

• Pyrido[2,3-d]pyrimidines and their use as kinase inhibitors
  申请人：GPC Biotech Inc.

  公开号：EP1914234A1

  公开（公告）日：2008-04-23

  The present invention provides derivatives of pyrido [2,3-d]pyrimidin-7-one of formula (I). These compounds are kinase inhibitors, including compounds that show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.

  本发明提供了公式(I)的吡啶并[2,3-d]嘧啶-7-酮衍生物。这些化合物是激酶抑制剂，包括显示抗增殖活性的化合物，包括对肿瘤细胞，对治疗癌症等疾病有用。
• PYRIDO Ý2, 3-D¨PYRIMIDINES AND THEIR USE AS KINASE INHIBITORS
  申请人：GPC Biotech Inc.

  公开号：EP2084159A1

  公开（公告）日：2009-08-05
• PYRIDO [2,3-D] PYRIMIDINES AND THEIR USE AS KINASE INHIBITORS
  申请人：Murthi Krisna

  公开号：US20110201594A1

  公开（公告）日：2011-08-18

  The present invention provides derivatives of pyrido[2,3-d]pyrimidin-7-one. These compounds are kinase inhibitors, including compounds that show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.
• Pyrido-[2,3-D] Pyrimidines and Their Use as Kinase Inhibitors
  申请人：MURTHI KRISHNA

  公开号：US20140163003A1

  公开（公告）日：2014-06-12

  The present invention provides derivatives of pyrido[2,3-d]pyrimidin-7-one. These compounds are kinase inhibitors, including compounds that show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.
• US8518958B2
  申请人：——

  公开号：US8518958B2

  公开（公告）日：2013-08-27