(1S,2R)-2-苯基环戊胺 | 676464-29-2

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: (1S,2R)-2-苯基环戊胺
• 英文名称: (1S,2R)-2-phenylcyclopentanamine
• 英文别名: trans-2-phenylcyclopentanamine；trans-2-phenyl-cyclopentylamin；Cyclopentylamine, 2-phenyl-, trans-；(1S,2R)-2-phenylcyclopentan-1-amine
• CAS: 676464-29-2
• 化学式: C₁₁H₁₅N
• 分子量: 161.247
• InChiKey: VNGYTYNUZHDMPP-MNOVXSKESA-N

物化性质

• 沸点：
  259.2±29.0 °C(Predicted)
• 密度：
  1.004±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  trans-2-phenylcyclopentyl methanesulfonate 在 sodium azide 、 palladium on activated charcoal 、 氢气 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 生成 (1S,2R)-2-苯基环戊胺
  参考文献：
  名称：

  [EN] ERK INHIBITORS
  [FR] INHIBITEURS D'ERK

  摘要：

  本发明提供了一种化合物(I)或其药学上可接受的盐、酯和前药，这些化合物是ERK2抑制剂。该发明还提供了一种包括至少一种化合物(I)和药学上可接受的载体的有效量的药物组合物。该发明还提供了一种包括至少一种化合物(I)的有效量和至少一种其他药学活性成分的有效量（例如，化疗药物等）以及药学上可接受的载体的药物组合物。

  公开号：

  WO2016100050A1

文献信息

• Inhibitors of Ion Channels
  申请人：Marron Brian Edward

  公开号：US20130072471A1

  公开（公告）日：2013-03-21

  Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted aryl sulfonamides, compositions comprising these compounds, as well as methods of using these compounds or compositions in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.

  本发明提供了在通过抑制电压门控钠通道中的钠离子流来治疗疾病方面有用的化合物、组合物和方法。更具体地，本发明提供了取代芳基磺酰胺、包含这些化合物的组合物，以及使用这些化合物或组合物治疗中枢或外周神经系统疾病，特别是疼痛和慢性疼痛的方法，通过阻断与所示条件的发生或复发相关的钠通道来实现。本发明的化合物、组合物和方法特别适用于通过抑制电压门控钠通道中的离子流来治疗神经病性或炎症性疼痛。
• INHIBITORS OF ION CHANNELS
  申请人：Marron Brian Edward

  公开号：US20090143358A1

  公开（公告）日：2009-06-04

  Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted aryl sulfonamides, compositions comprising these compounds, as well as methods of using these compounds or compositions in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.

  本发明提供了化合物、组合物和方法，通过抑制电压门控钠通道中的钠离子流来治疗疾病。更具体地，本发明提供了取代芳基磺酰胺、包含这些化合物的组合物，以及使用这些化合物或组合物治疗中枢或外周神经系统疾病，特别是疼痛和慢性疼痛的方法，通过阻止与所示疾病的发生或复发有关的钠通道。本发明的化合物、组合物和方法特别适用于通过抑制电压门控钠通道中的离子流来治疗神经病理性或炎症性疼痛。
• Kinetic resolution of (±)-trans- and (±)-cis-2-phenylcyclopentanamine by CALB-catalyzed aminolysis of esters: the key role of the leaving group
  作者：Javier González-Sabı́n、Vicente Gotor、Francisca Rebolledo

  DOI：10.1016/j.tetasy.2003.11.013

  日期：2004.2

  Kinetic resolution of (+/-)-trans- and (+/-)-cis-2-phenylcyclopentanamine is effectively performed by lipase B from Candida antarctica, (CALB)-catalyzed aminolysis reaction. Whereas reaction between (+/-)-trans-2-phenylcyclopentanamine and ethyl acetate proceeds with a very high E value (>200) and conversion (50%), the corresponding acetylation of ()-cis-2-phenylcyclopentanamine happens with low E value (16) and conversion (28%). Nevertheless, this problem is overcome using other acyl donors such as (+/-)-1-phenylethyl and (+/-)-cis-2-phenylcyclopentyl methoxyacetates. The influence of the acyl donor on the CALB-catalyzed aminolysis of (+/-)-cis-2-phenylcyclopentanamine is also studied. (C) 2003 Elsevier Ltd. All rights reserved.
• BROWN, HERBERT C.;KIM, KEE-WON;SREBNIK, MORRIS;SINGARAM, BAKTHAN, TETRAHEDRON, 43,(1987) N 18, 4071-4078
  作者：BROWN, HERBERT C.、KIM, KEE-WON、SREBNIK, MORRIS、SINGARAM, BAKTHAN

  DOI：——

  日期：——
• CYCLOPENTYL SULFONAMIDE DERIVATIVES
  申请人：ELI LILLY AND COMPANY

  公开号：EP1246797B1

  公开（公告）日：2008-07-23