2-Bromomethyl-1-phenylnapthalene | 171726-26-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-Bromomethyl-1-phenylnapthalene
• 英文别名: 2-(bromomethyl)-1-phenylnaphthalene
• CAS: 171726-26-4
• 化学式: C₁₇H₁₃Br
• 分子量: 297.194
• InChiKey: FSRMROFTQFFSQW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  2-Bromomethyl-1-phenylnapthalene 在 potassium permanganate 、 水 、 calcium carbonate 作用下， 以 1,4-二氧六环 、 水 、 丙酮 为溶剂， 反应 16.0h， 生成 7h-苯并(c)芴-7-酮
  参考文献：
  名称：

  Syndiospezifische polymerisation von propylen: 3-, 4-, 3,4- und 4,5-substituierte zirkonocenkomplexe des typs (C13H8−nRnCR′2C5H4)ZrCl2 (n = 1,2; R  Alkyl, Aryl; R′  Me, Ph)

  摘要：

  Substituents in the positions 3, 4, 5 and 6 of the fluorenylidene fragment clearly influence the polymerization behaviour of the syndiospecific catalyst systems (C(13)H(8-n)R(n)CR(2)'C5H4)ZrCl2/MAO (n = 1, 2; R = alkyl, aryl; R' = Me, Ph). We report seven new catalyst precursors of this type, including first polymerization results. An X-ray study of the 4,5-dimethyl derivative 10b explains the reduced activity and stereospecifity of this catalyst.

  DOI：

  10.1016/0022-328x(95)06048-2
• 作为产物：
  描述：

  2-甲基-1-苯基萘 在 N-溴代丁二酰亚胺(NBS) 、 偶氮二异丁腈 作用下， 以 四氯化碳 为溶剂， 生成 2-Bromomethyl-1-phenylnapthalene
  参考文献：
  名称：

  Syndiospezifische polymerisation von propylen: 3-, 4-, 3,4- und 4,5-substituierte zirkonocenkomplexe des typs (C13H8−nRnCR′2C5H4)ZrCl2 (n = 1,2; R  Alkyl, Aryl; R′  Me, Ph)

  摘要：

  Substituents in the positions 3, 4, 5 and 6 of the fluorenylidene fragment clearly influence the polymerization behaviour of the syndiospecific catalyst systems (C(13)H(8-n)R(n)CR(2)'C5H4)ZrCl2/MAO (n = 1, 2; R = alkyl, aryl; R' = Me, Ph). We report seven new catalyst precursors of this type, including first polymerization results. An X-ray study of the 4,5-dimethyl derivative 10b explains the reduced activity and stereospecifity of this catalyst.

  DOI：

  10.1016/0022-328x(95)06048-2

文献信息

• Gold-Catalyzed 6-<i>Exo</i>-<i>Dig</i>Cycloisomerization: A Versatile Approach to Functionalized Phenanthrenes
  作者：Chao Shu、Long Li、Cheng-Bin Chen、Hong-Cheng Shen、Long-Wu Ye

  DOI：10.1002/asia.201400034

  日期：2014.6

  A novel gold‐catalyzed 6‐exo‐dig cycloisomerization of o‐propargylbiaryls has been developed that provides ready access to functionalized phenanthrenes in largely good to excellent yields. Notable features of this method are readily available starting materials, mild reaction conditions, and broad substrate scope.

  已经开发了一种新型的金催化的邻炔丙基联芳基的6- exo - dig环异构化方法，该方法可以方便地获得官能化的菲，而且收率大体上很高。该方法的显着特征是易于获得的起始原料，温和的反应条件和广泛的底物范围。
• Synthesis of novel GABA uptake inhibitors. part 6 † †See ref 1. : Preparation and evaluation of N -Ω asymmetrically substituted nipecotic acid derivatives
  作者：Knud Erik Andersen、Jesper Lau、Behrend F. Lundt、Hans Petersen、Per O. Huusfeldt、Peter D. Suzdak、Michael D.B. Swedberg

  DOI：10.1016/s0968-0896(01)00148-1

  日期：2001.11

  cycloalkylene moiety as well as other modifications in the lipophilic part. The in vitro values for inhibition of [(3)H]-GABA uptake in rat synaptosomes was determined for each compound, and it was found that several of the novel compounds inhibit GABA uptake as potently as their known symmetrical reference analogues. Several of the novel compounds were also evaluated for their ability to inhibit clonic seizures

  在该实验室发布的先前一系列有效的GABA吸收抑制剂中，我们注意到已知的GABA吸收抑制剂（例如4 [1-（4,4-二苯基-3-丁烯基））中双芳族部分的取代方式不对称-3-哌啶羧酸]和5 [（R）-1-（4,4-双（3-甲基-2-噻吩基）-3-丁烯基）-3-哌啶羧酸]对高亲和力是有益的。这促使我们研究已知的对称GABA吸收抑制剂的不对称类似物，其中一个芳基已与烷基，亚烷基或亚环烷基部分以及亲脂部分中的其他修饰进行了交换。确定每种化合物在大鼠突触小体中抑制[（3）H] -GABA吸收的体外值，并且发现几种新颖的化合物与其已知的对称参考类似物一样有效地抑制了GABA的吸收。还评估了几种新型化合物在体内抑制15 mg / kg（ip）剂量的6,7-二甲氧基-4-乙基-β-咔啉-3-羧酸甲酯（DMCM）诱导的阵挛性癫痫发作的能力。某些化合物，例如18 [[R] -1-（2-（（（（1,2-双（2-氟
• Heterocyclic chemistry
  申请人：Novo Nordisk A/S

  公开号：US05604242A1

  公开（公告）日：1997-02-18

  The present invention relates to therapeutically active azaheterocyclic compounds, a method of preparing the same and to pharmaceutical compositions comprising the compounds. The novel compounds are useful in treating a central nervous system ailment related to the GABA uptake.

  本发明涉及治疗活性的氮杂环化合物、其制备方法以及包含该化合物的药物组合物。这些新型化合物可用于治疗与GABA摄取有关的中枢神经系统疾病。
• Organometallic fluorenyl compounds, preparation, and use
  申请人：Phillips Petroleum Company

  公开号：US05451649A1

  公开（公告）日：1995-09-19

  Benzofluorenyl-containing metallocenes are disclosed along with methods for making the metallocenes. Also disclosed are methods for using the metallocenes as polymerization catalysts. In addition, polymers resulting from such polymerizations are disclosed.

  本文公开了含苯并芴基的金属茂化合物以及制备这些金属茂化合物的方法。还公开了使用这些金属茂化合物作为聚合催化剂的方法。此外，还公开了由这些聚合反应产生的聚合物。
• KALTENBRONN J. S., J. MED. CHEM., 1977, 20, NO 4, 596-598
  作者：KALTENBRONN J. S.

  DOI：——

  日期：——