2-(1,2,4-恶二唑-3-基)吡啶 | 13389-59-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 中文名称: 2-(1,2,4-恶二唑-3-基)吡啶
• 英文名称: 3-(2'-pyridyl)-1,2,4-oxadiazole
• 英文别名: 2-[1,2,4]oxadiazol-3-yl-pyridine；2-(1,2,4-Oxadiazolyl-3)pyridine；3-<2>Pyridyl-<1,2,4>oxadiazol；2-(1,2,4-Oxadiazol-3-yl)pyridine；3-pyridin-2-yl-1,2,4-oxadiazole
• CAS: 13389-59-8
• 化学式: C₇H₅N₃O
• 分子量: 147.136
• InChiKey: ZAAIEOSUVDRLGD-UHFFFAOYSA-N

物化性质

• 沸点：
  289.6±32.0 °C(Predicted)
• 密度：
  1?+-.0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 海关编码：
  2934999090

反应信息

• 作为反应物：
  描述：

  ammonium hexafluorophosphate 、 水合三氯化钌 、 2-(1,2,4-恶二唑-3-基)吡啶 以 乙醇 为溶剂， 以0%的产率得到{Ru(3-(2`-pyridyl)-1,2,4-oxadiazole)3}(PF6)2
  参考文献：
  名称：

  Orellana, Guillermo; Alvarez-Ibarra, Carlos; Quiroga, Maria Luz, Bulletin des Societes Chimiques Belges, 1988, vol. 97, # 10, p. 731 - 742

  摘要：

  DOI：
• 作为产物：
  描述：

  咪唑并[1,5-a]吡啶 在 盐酸 、 sodium nitrite 作用下， 生成 2-(1,2,4-恶二唑-3-基)吡啶
  参考文献：
  名称：

  The conversion of imidazo[1,5-a]pyridines into 3-(2-pyridyl)-1,2,4-oxadiazoles

  摘要：

  DOI：

  10.1021/jo01283a015

文献信息

• [EN] PYRIDIN-2-YL DERIVATIVES AS IMMUNOMODULATING AGENTS<br/>[FR] DÉRIVÉS DE PYRIDIN-2-YLE UTILISÉS COMME AGENTS IMMUNOMODULATEURS
  申请人：ACTELION PHARMACEUTICALS LTD

  公开号：WO2009109872A1

  公开（公告）日：2009-09-11

  The invention relates to pyridine derivatives of Formula (I), wherein A, R1, R2, R3, R4, R5, R6 and R7 are as described in the description, their preparation and their use as pharmaceutically active compounds. Said compounds particularly act as immunomodulating agents.

  这项发明涉及公式（I）的吡啶衍生物，其中A、R1、R2、R3、R4、R5、R6和R7如描述中所述，它们的制备以及它们作为药用活性化合物的用途。这些化合物特别作为免疫调节剂。
• Substituted Amide Compounds
  申请人：Oberboersch Stefan

  公开号：US20080306084A1

  公开（公告）日：2008-12-11

  Substituted amide compounds corresponding to formula I: processes for preparing them, pharmaceutical compositions containing these compounds, and the use of substituted amide derivatives for the preparation of medicaments for the treatment of pain and various other conditions.

  将与式I相对应的取代酰胺化合物： 制备它们的方法，含有这些化合物的药物组合物，以及利用取代酰胺衍生物制备用于治疗疼痛和其他各种疾病的药物的用途。
• [EN] BIPYRIDYL AMIDES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5<br/>[FR] AMIDES BIPYRIDYLES EN TANT QUE MODULATEURS DU RÉCEPTEUR-5 MÉTABOTROPIQUE DU GLUTAMATE
  申请人：MERCK & CO INC

  公开号：WO2005079802A1

  公开（公告）日：2005-09-01

  The present invention is directed to novel amides such as those of Formula (I): (I) which are mGluR5 modulators useful in the treatment or prevention of diseases and conditions in which mGluR5 is involved, including but not limited to psychiatric and mood disorders such as schizophrenia, anxiety, depression, bipolar disorders, and panic, as well as in the treatment of pain, Parkinson’s disease, cognitive dysfunction, epilepsy, circadian rhythm and sleep disorders, such as shift-work induced sleep disorder and jet-lag, drug addiction, drug abuse, drug withdrawal, obesity and other diseases. The invention is also directed to pharmaceutical compositions comprising these compounds. This invention further provides a method of treatment of these disorders and conditions by the administration of an effective amount of these novel amides and/or compositions containing these compounds.

  本发明涉及新型酰胺，如式(I)所示的酰胺：(I)，这些酰胺是mGluR5调节剂，可用于治疗或预防涉及mGluR5的疾病和症状，包括但不限于精神疾病和情绪障碍，如精神分裂症、焦虑、抑郁、双相障碍和恐慌，以及用于治疗疼痛、帕金森病、认知功能障碍、癫痫、昼夜节律和睡眠障碍，如倒班工作引起的睡眠障碍和时差反应，药物成瘾、药物滥用、药物戒断、肥胖和其他疾病。本发明还涉及包含这些化合物的药物组合物。本发明进一步提供了通过给予这些新型酰胺和/或含有这些化合物的组合物的有效量来治疗这些疾病和症状的方法。
• [EN] BIPYRIDYL AMINES AND ETHERS AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTOR-5<br/>[FR] AMINES ET ETHERS DE BIPYRIDYLE UTILISES COMME MODULATEURS DU RECEPTEUR 5 METABOTROPIQUE AU GLUTAMATE
  申请人：MERCK & CO INC

  公开号：WO2005021529A1

  公开（公告）日：2005-03-10

  The present invention is directed to novel bipyridyl amine and ether compounds such as those of Formula (I): (I) (where R?1#191, R?2#191, R?3#191, X and Y are as defined herein) which are mGluR5 modulators useful in the treatment or prevention of diseases and conditions in which mGluR5 is involved, including but not limited to psychiatric and mood disorders such as schizophrenia, anxiety, depression, bipolar disorders, and panic, as well as in the treatment of pain, Parkinson’s disease, cognitive dysfunction, epilepsy, circadian rhythm and sleep disorders, such as shift-work induced sleep disorder and jet-lag, drug addiction, drug abuse, drug withdrawal, obesity and other diseases. The invention is also directed to pharmaceutical compositions comprising these compounds. This invention further provides a method of treatment of these disorders and conditions by the administration of an effective amount of these novel bipyridyl amine and/or ether compounds and/or compositions containing these compounds.

  本发明涉及一种新型的双吡啶基胺和醚化合物，例如式(I)中的化合物：（I）（其中R?1#191，R?2#191，R?3#191，X和Y的定义如本文所述），这些化合物是mGluR5调节剂，可用于治疗或预防涉及mGluR5的疾病和症状，包括但不限于精神和情绪障碍，如精神分裂症、焦虑、抑郁症、双相情感障碍和恐慌，以及用于疼痛、帕金森病、认知功能障碍、癫痫、昼夜节律和睡眠障碍，如倒班工作引起的睡眠障碍和时差反应，药物成瘾、药物滥用、戒断综合征、肥胖症和其他疾病的治疗。本发明还涉及包含这些化合物的药物组合物。本发明还提供了一种通过给予这些新型双吡啶基胺和/或醚化合物和/或含有这些化合物的组合物的有效量来治疗这些障碍和症状的方法。
• Feed compositions containing 2-(.alpha.-pyridyl)-.DELTA..sup.2
  申请人：SmithKline Beckman Corporation

  公开号：US04680304A1

  公开（公告）日：1987-07-14

  Selected 2-(.alpha.-pyridyl)-.DELTA..sup.2 -heterocyclic compounds are used as active ingredients in animal feed compositions and in methods for increasing the growth or feed efficiency of monogastric animals. An active ingredient for use in this invention is 3,4-dihydro-4-hydroxy-5-(3-hydroxy)-2-pyridinyl)-4-methyl-2H-pyrrole-5-car boxamide.

  选择的2-(α-吡啶基)-Δ2-杂环化合物作为动物饲料组合物中的活性成分，并用于增加单胃动物的生长或饲料利用率的方法。本发明中用作活性成分的是3,4-二氢-4-羟基-5-(3-羟基)-2-吡啶基)-4-甲基-2H-吡咯-5-羧酰胺。