2-(1,2,4-恶二唑-3-基)吡嗪 | 112570-98-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 2-(1,2,4-恶二唑-3-基)吡嗪
• 英文名称: 3-Pyrazinyl-1,2,4-oxadiazole
• 英文别名: 3-pyrazin-2-yl-1,2,4-oxadiazole
• CAS: 112570-98-6
• 化学式: C₆H₄N₄O
• 分子量: 148.12
• InChiKey: UMLFDKVERILJEA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  64.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  吡嗪-2-甲胺肟 、 原甲酸三乙酯 以66%的产率得到
  参考文献：
  名称：

  PANCECHOWSKA-KSEPKO D.; FOKS H.; JANOWIEC M.; ZWOLSKA-KWIEK Z., ACTA POL. PHARM., 43,(1986) N 3, 211-217

  摘要：

  DOI：

文献信息

• [EN] ALPHA-SUBSTITUTED N-SULFONYL GYLCINE AMIDES ANTAGONISTS OF CCR10, COMPOSITIONS CONTAINING THE SAME AND METHODS FOR USING THEM<br/>[FR] N-SULFONYLGLYCINAMIDES ALPHA-SUBSTITUÉS ANTAGONISTES DU CCR10, COMPOSITIONS LES CONTENANT, ET LEURS PROCÉDÉS D'UTILISATION
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2009142984A1

  公开（公告）日：2009-11-26

  Disclosed is a compound of formula (I). Wherein R1, R2 Ar and Cy are as defined herein, or a pharmaceutically acceptable salt thereof. Also disclosed are pharmaceutical compositions of the compound of formula (I), methods of making the compounds of formula I, and methods of using the compounds of formula (I) to treat a disorder associated with activation of CCR10.

  公开的是式（I）的化合物。其中，R1、R2、Ar和Cy如本文所定义，或其药学上可接受的盐。还公开了式（I）化合物的药物组合物，制备式I化合物的方法，以及使用式（I）化合物治疗与CCR10激活相关的疾病的方法。
• [EN] 2-SULFONYLAMINO-4-HETEROARYL BUTYRAMIDE ANTAGONISTS OF CCR10<br/>[FR] ANTAGONISTES DE 2-SULFONYLAMINO-4-HÉTÉROARYL BUTYRAMIDE DE CCR10
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2009126675A1

  公开（公告）日：2009-10-15

  This invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein R1, R2, R4. Ar and Het are as defined herein. The invention also relates to methods of using the compound of formula (I) to treat a diseases and disorders that are mediated or sustained through the activity of CCR10.

  本发明涉及一种具有式（I）的化合物及其药学上可接受的盐，其中R1、R2、R4、Ar和Het如本文中所定义。该发明还涉及使用式（I）的化合物治疗通过CCR10活性介导或维持的疾病和紊乱的方法。
• ALPHA-SUBSTITUTED N-SULFONYL GYLCINE AMIDES ANTAGONISTS OF CCR10, COMPOSITIONS CONTAINING THE SAME AND METHODS FOR USING THEM
  申请人：Cogan Derek

  公开号：US20110275612A1

  公开（公告）日：2011-11-10

  Disclosed is a compound of formula (I). Wherein R 1 , R 2 Ar and Cy are as defined herein, or a pharmaceutically acceptable salt thereof. Also disclosed are pharmaceutical compositions of the compound of formula (I), methods of making the compounds of formula I, and methods of using the compounds of formula (I) to treat a disorder associated with activation of CCR10.

  本发明揭示了一种化合物，其化学式为(I)，其中R1、R2Ar和Cy如本文所定义，或其药学上可接受的盐。本发明还揭示了化合物(I)的药物组合物、制备化合物(I)的方法，以及使用化合物(I)治疗与CCR10激活相关的疾病的方法。
• 2-SULFONYLAMINO-4-HETEROARYL BUTYRAMIDE ANTAGONISTS OF CCR10
  申请人：Abeywardane Asitha

  公开号：US20110275800A1

  公开（公告）日：2011-11-10

  This invention relates to a compound of formula (I) and the pharmaceutically acceptable salts thereof wherein R 1 , R 2 , R 4 . Ar and Het are as defined herein. The invention also relates to methods of using the compound of formula (I) to treat a diseases and disorders that are mediated or sustained through the activity of CCR 10 .

  本发明涉及公式(I)的化合物及其药学上可接受的盐，其中R1、R2、R4、Ar和Het的定义如本文所述。本发明还涉及使用公式(I)的化合物治疗通过CCR10活性介导或持续的疾病和障碍的方法。
• Novel substituted pyrazinyl-1,2,4-oxadiazoles, processes for preparing the same and a pharmaceutical composition containing the same
  申请人：Merck & Co., Inc.

  公开号：EP0040422A1

  公开（公告）日：1981-11-25

  Novel substituted pyrazinyl-1,2,4-oxadiazoles of the formulas are disclosed wherein R is hydrogen or lower alkyl (C1-5), R1 is hydrogen or lower alkyl (C1-5), R2 is hydrogen or lower alkyl (C1-5), R3 is hydrogen or lower alkyl (C1-5), R and R' can be joined to form an alkylene group of from 2-4 i carbon atoms, R4 is lower alkyl (C1-5) X is halo, cyano or phenyl, and Y- is chloride, bromide or iodide, or a suitable anion. Processing for preparing the same are also described. The compounds are useful in the treatment of edema and hypertension.

  新颖的取代吡嗪基-1,2,4-恶二唑，其式如下 的新型取代吡嗪基-1,2,4-恶二唑 R 是氢或低级烷基 (C1-5)、 R1 是氢或低级烷基 (C1-5) R2 是氢或低级烷基 (C1-5) R3 是氢或低级烷基（C1-5）、 R 和 R' 可以连接成一个含有 2-4 i 个碳原子的亚烷基、 R4 是低级烷基（C1-5） X 是卤代、氰基或苯基，以及 Y- 是氯化物、溴化物或碘化物，或合适的阴离子。 此外，还介绍了制备方法。这些化合物可用于治疗水肿和高血压。