10-{3-[4-(N-Boc-2-aminoethyl)piperazinyl]propyl}-2-trifluoromethylphenothiazine | 1009797-49-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: 10-{3-[4-(N-Boc-2-aminoethyl)piperazinyl]propyl}-2-trifluoromethylphenothiazine
• 英文别名: tert-butyl N-[2-[4-[3-[2-(trifluoromethyl)phenothiazin-10-yl]propyl]piperazin-1-yl]ethyl]carbamate
• CAS: 1009797-49-2
• 化学式: C₂₇H₃₅F₃N₄O₂S
• 分子量: 536.662
• InChiKey: VCCFQXPNULLGMZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  37
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  73.4
• 氢给体数：
  1
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  10-{3-[4-(N-Boc-2-aminoethyl)piperazinyl]propyl}-2-trifluoromethylphenothiazine 在 三氟乙酸 、 水 、 碳酸氢钠 作用下， 以 二氯甲烷 为溶剂， 生成 10-{3-[4-(2-aminoethyl)piperazinyl]propyl}2-trifluoromethylphenothiazine
  参考文献：
  名称：

  WO2008/27521

  摘要：

  公开号：
• 作为产物：
  描述：

  1-(N-Boc-氨乙基)哌嗪 、 10-(3-氯丙基)-2-(三氟甲基)-10H-吩噻嗪 在 potassium carbonate 、 sodium iodide 作用下， 以 丁酮 为溶剂， 反应 24.0h， 以64%的产率得到10-{3-[4-(N-Boc-2-aminoethyl)piperazinyl]propyl}-2-trifluoromethylphenothiazine
  参考文献：
  名称：

  WO2008/27521

  摘要：

  公开号：

文献信息

• Novel Compositions and Methods of Treating Diseases Using the Same
  申请人：Roth Stephen

  公开号：US20120035161A1

  公开（公告）日：2012-02-09

  The invention includes compositions and methods for inhibiting proliferation and inducing apoptosis in activated lymphocytes, treating diseases associated with activated lymphocytes, or treating PAH.

  本发明涉及抑制活化淋巴细胞增殖和诱导凋亡的组合物和方法，用于治疗与活化淋巴细胞相关的疾病或治疗PAH。
• NOVEL COMPOSITIONS AND METHODS FOR TREATMENT OF DISEASES RELATED TO ACTIVATED LYMPHOCYTES
  申请人：Immune Control, Inc.

  公开号：EP2061788A1

  公开（公告）日：2009-05-27
• Novel methods for treatment of diseases related to activated lymphocytes
  申请人：Roth Stephen

  公开号：US20080125415A1

  公开（公告）日：2008-05-29

  The present invention relates to inhibiting proliferation and inducing apoptosis in activated lymphocytes, including T cells and B cells. The invention also provides compositions and methods for inhibiting proliferation and inducing apoptosis in activated lymphocytes, as well methods for treating diseases associated with activated lymphocytes by administering 5-HT receptor antagonists.
• Novel compositions for treatment of diseases related to activated lymphocytes
  申请人：Roth Stephen

  公开号：US20080132697A1

  公开（公告）日：2008-06-05

  The present invention relates to inhibiting proliferation and inducing apoptosis in activated lymphocytes, including T cells and B cells. The invention also provides compositions and methods for inhibiting proliferation and inducing apoptosis in activated lymphocytes, as well methods for treating diseases associated with activated lymphocytes by administering 5-HT receptor antagonists.
• US7923445B2
  申请人：——

  公开号：US7923445B2

  公开（公告）日：2011-04-12