2-phenyl-2-p-tolyl-ethylamine | 6582-13-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-phenyl-2-p-tolyl-ethylamine
• 英文别名: 2-Phenyl-2-p-tolyl-aethylamin；(+/-)-2-(p-Tolyl)-2-phenylethylamin；(+/-)-2-Phenyl-2-p-tolyl-aethylamin；2-(4-Methylphenyl)-2-phenylethanamine
• CAS: 6582-13-4
• 化学式: C₁₅H₁₇N
• mdl: MFCD03077518
• 分子量: 211.307
• InChiKey: ZYFLABCDJVBRMZ-UHFFFAOYSA-N

物化性质

• 沸点：
  124-125 °C(Press: 0.35 Torr)
• 密度：
  1.0341 g/cm3(Temp: 24 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  溴乙烷 、 2-phenyl-2-p-tolyl-ethylamine 在 sodium hydroxide 作用下， 生成 diethyl-(2-phenyl-2-p-tolyl-ethyl)-amine
  参考文献：
  名称：

  Kotschhetkow; Petrutschenko, Zhurnal Obshchei Khimii, 1958, vol. 28, p. 2252,2254,2255;engl.Ausg.S.2288.2289,2290

  摘要：

  DOI：
• 作为产物：
  描述：

  2-(4-甲基苯基)-2-苯基乙腈 在 甲醇 、 镍 作用下， 生成 2-phenyl-2-p-tolyl-ethylamine
  参考文献：
  名称：

  Kotschhetkow; Petrutschenko, Zhurnal Obshchei Khimii, 1958, vol. 28, p. 2252,2254,2255;engl.Ausg.S.2288.2289,2290

  摘要：

  DOI：

文献信息

• [EN] PROCESS FOR PREPARING (+)-2-(4-CHLOROPHENYL)-3-METHYL BUTANOIC ACID<br/>[FR] PROCEDE DE PREPARATION D'ACIDE (+)-2-(4-CHLOROPHENYL)-3-METHYLE BUTANOIQUE
  申请人：COUNCIL SCIENT IND RES

  公开号：WO2004060850A1

  公开（公告）日：2004-07-22

  The present invention relates to an environmentally benign process for preparation of (+)2-(4-chlorophenyl)-3-methyl butanoic acid (+ CPA) from its racemic acid, using optically active arylamines like (-) PEA in hydrophilic/hydrophobic organic solvents like butanol, propanol etc. as aqueous mixtures, separating the desired (+) CPA salt, mother liquor by filtration and refining the (+) CPA salt in the same solvent system as used for resolution, recovering the desired acid in high optical purity by extracting with aqueous mineral acid. The mother liquor is concentrated under vacuum and extracted with aqueous mineral acid to obtain undesired (-) CPA which was recovered and recycled after racemization. The aqueous mineral acid layer thus obtained is mixed with corresponding aqueous mineral acid layer obtained from (+) CPA recovery and extracted with aqueous caustic lie solution to recover the optically active amine used for resolution. Thus the method described effectively provides a process for recovery and recycle of the undesired (-) CPA, optically active amine, besides obtaining the desired (+) CPA in high optical purity.

  本发明涉及一种环保的制备方法，从其外消旋酸中使用光学活性芳胺（如（-）PEA）在亲水/疏水有机溶剂（如丁醇、丙醇等）的水混合物中制备(+ )2-(4-氯苯基)-3-甲基丁酸(+ CPA)，通过过滤分离所需的(+ CPA)盐和母液，并在与分离所用的相同溶剂体系中精制(+ CPA)盐，通过用水溶性矿酸提取来高度光学纯度地回收所需的酸。母液在真空下浓缩并用水溶性矿酸提取，以获得不需要的(-) CPA，经旋光化后回收和再循环。因此，所述方法有效地提供了回收和再循环不需要的(-) CPA和光学活性胺的过程，同时获得所需的高度光学纯度的(+ ) CPA。
• OPTICALLY ACTIVE POLY(DIPHENYLACETYLENE) COMPOUND, PREPARATION METHOD THEREFOR, AND USE THEREOF AS OPTICAL ISOMER SEPARATING AGENT
  申请人：NATIONAL UNIVERSITY CORPORATION KANAZAWA UNIVERSITY

  公开号：US20150376308A1

  公开（公告）日：2015-12-31

  The present invention provides an optically active poly(diphenylacetylene) compound represented by the following formula (I): [wherein each symbol is as described in the DESCRIPTION], and a production method thereof, an optical isomer separating agent containing the poly(diphenylacetylene) compound, and a packing material for a chiral column, containing the optical isomer separating agent coated on a carrier. According to the present invention, a practical optical isomer separation agent having a high optical resolution ability for a wide variety of racemic compounds and an optical isomer separation method can be provided.

  本发明提供一种光学活性的聚二苯基乙炔化合物，其化学式如下（I）：[其中每个符号如说明书所述]，以及其生产方法，含有聚二苯基乙炔化合物的光学异构体分离剂，以及在载体上涂覆了光学异构体分离剂的手性柱的填料材料。根据本发明，可以提供一种实用的光学异构体分离剂，具有对各种混合物的高光学分辨能力，并提供一种光学异构体分离方法。
• A method of resolving optical isomers of 2,2-dimethyl-3-(2,2-dichlorovinyl) cyclopropanecarboxylic acid and a novel salt used in this method
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0034428A2

  公开（公告）日：1981-08-26

  A method of preparing (1R,cis)-2,2-dimethyl-3- (2,2-dichlorovinyl)cyclopropanecarboxylic acid (useful as the acid part of effective insecticidal esters) comprises reacting 2,2-dimethyl-3-(2,2-dichlorovinyl) cyclopropanecarboxylic acid containing 70% or more of the cis-form with an equimolar or lesser amount of (+)-1-phenyl-2-(p-tolyl)ethylamine, separating and, if necessary, purifying the resulting diastereomer salt, (which is a new compound) and decomposing said salt with a base or an acid to yield (1R,cis)-2,2-dimethyl-3- (2,2-dichlorovinyl)cyclopropanecarboxylic acid. The corresponding (1S,cis) acid may be obtained by using (-)-1-phenyl-2-(p-tolyl)ethylamine.

  制备(1R,cis)-2,2-二甲基-3-(2,2-二氯乙烯基)环丙烷羧酸（可用作有效杀虫酯的酸部分）的方法包括：将含有 70% 或更多顺式形式的 2,2-二甲基-3-(2,2-二氯乙烯基)环丙烷羧酸与等摩尔或更少量的(+)-1-苯基-2-(对甲苯基)乙胺反应、分离并在必要时纯化得到的非对映异构盐（这是一种新化合物），并用碱或酸分解所述盐，得到 (1R,cis)-2,2-二甲基-3-(2,2-二氯乙烯基)环丙烷羧酸。相应的(1S,cis)酸可通过使用(-)-1-苯基-2-(对甲苯基)乙胺获得。
• Method for optical resolution of 2-(4-chlorophenyl)-3-methyl-butanoic acid
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0060466A1

  公开（公告）日：1982-09-22

  A method for optical resolution of 2-(4-chlorophenyl)-3-methylbutanoic acid, which comprises crystallizing out the salt between (+) or (-)-2-(4-chlorophenyl)-3-methylbutanoic acid and diethylamine in a molar proportion of 2: 1 predominantly from a supersaturated solution of the salt of 2-(4-chlorophenyl)-3-methylbutanoic acid with diethylamine, collecting the crystallized salt and decomposing the collected salt under an acidic condition to obtain the corresponding optically active acid.

  一种对 2-(4-氯苯基)-3-甲基丁酸进行光学解析的方法，包括从 2-(4-氯苯基)-3-甲基丁酸与二乙胺的过饱和溶液中结晶出摩尔比例为 2.1 的(+)或(-)-2-(4-氯苯基)-3-甲基丁酸与二乙胺之间的盐：主要是从 2-(4-氯苯基)-3-甲基丁酸与二乙胺的过饱和溶液中结晶出盐，收集结晶盐并在酸性条件下分解收集的盐，以获得相应的光学活性酸。
• Fungicidal composition comprising alpha-substituted ethylphosphinic acids or their salts, and method of preventing or curing plant disease using them
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0063464A1

  公开（公告）日：1982-10-27

  A fungicidal composition which comprises as an active ingredient a fungicidally effective amount of a compound of the formula: wherein X is a hydroxyl group or a hydroxyamino group, or a salt thereof together with an inert carrier or diluent.

  一种杀真菌组合物，其活性成分包括杀真菌有效量的式化合物： 其中 X 为羟基或羟基氨基，或其盐与惰性载体或稀释剂一起使用。