2-hydroxy-3,5-diisopropyl-benzoic acid methyl ester | 53434-12-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-hydroxy-3,5-diisopropyl-benzoic acid methyl ester
• 英文别名: 2-Hydroxy-3,5-diisopropyl-benzoesaeure-methylester；3,3-Diisopropyl-salicylsaeure-methylester；3.5-Diisopropyl-salicylsaeure-methylester；Methyl 2-hydroxy-3,5-di(propan-2-yl)benzoate
• CAS: 53434-12-1
• 化学式: C₁₄H₂₀O₃
• 分子量: 236.311
• InChiKey: GQZPTOIDTYPUMT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3,5-二异丙基邻羟基苯甲酸 在 甲醇 、 硫酸 作用下， 生成 2-hydroxy-3,5-diisopropyl-benzoic acid methyl ester
  参考文献：
  名称：

  Desseigne, Bulletin de la Societe Chimique de France, 1948, p. 68

  摘要：

  DOI：

文献信息

• Acetylenic aryl sulfonate hydroxamic acid TACE and matrix metalloproteinase inhibitors
  申请人：Wyeth Holdings Corporation

  公开号：US20040127524A1

  公开（公告）日：2004-07-01

  Hydroxamic acids having the formula 1 are useful in treating disease conditions mediated by TNF-□, such as rheumatoid arthritis, graft rejection, cachexia, inflammation, fever, insulin resistance, septic shock, congestive heart failure, inflammatory disease of the central nervous system, inflammatory bowel disease or HIV infection.

  具有公式1的羟甲酸在治疗由TNF-α介导的疾病情况中具有用处，例如类风湿性关节炎、移植排斥、虚弱、炎症、发热、胰岛素抵抗、脓毒性休克、充血性心力衰竭、中枢神经系统的炎症性疾病、炎症性肠病或HIV感染。
• Acetylenic aryl sulfonate hydroxamic acid tace and matrix metalloproteinase inhibitors
  申请人：Levin Ian Jeremy

  公开号：US20070155834A1

  公开（公告）日：2007-07-05

  Hydroxamic acids having the formula are useful in treating disease conditions mediated by TNF-□, such as rheumatoid arthritis, graft rejection, cachexia, inflammation, fever, insulin resistance, septic shock, congestive heart failure, inflammatory disease of the central nervous system, inflammatory bowel disease or HIV infection.

  具有以下化学式的羟肟酸对治疗由TNF-□介导的疾病条件具有用处，例如类风湿性关节炎、移植排斥、消瘦、炎症、发热、胰岛素抵抗、脓毒性休克、充血性心力衰竭、中枢神经系统炎症性疾病、炎症性肠病或HIV感染。
• US7199155B2
  申请人：——

  公开号：US7199155B2

  公开（公告）日：2007-04-03
• US7485667B2
  申请人：——

  公开号：US7485667B2

  公开（公告）日：2009-02-03
• [EN] ACETYLENIC ARYL SULFONATE HYDROXAMIC ACID TACE AND MATRIX METALLOPROTEINASE INHIBITORS<br/>[FR] TACE D'ACIDE HYDROXAMIQUE SULFONATE ARYLE ACETYLENE ET INHIBITEURS DE METALLOPROTEINASE MATRICIELLE
  申请人：WYETH CORP

  公开号：WO2005021489A2

  公开（公告）日：2005-03-10

  Hydroxamic acids having the formula (B) are useful in treating disease conditions mediated by TNF-(x, euch as rheumatoid arthritis, graft rejection, cachexia, inflammation, fever, insulin resistance, septic shock, congestive heart hHure, inflammatory disease of the central nervous system, inflammatory bowel disease or HIV infection.