4'-戊基-4-联苯甲酰胺 | 67613-13-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4'-戊基-4-联苯甲酰胺
• 英文名称: 4'-n-Pentyl-biphenyl-4-carbonsaeureamid
• 英文别名: 4-n-Pentyl-4'-biphenyl-carboxamid；[1,1'-Biphenyl]-4-carboxamide, 4'-pentyl-；4-(4-pentylphenyl)benzamide
• CAS: 67613-13-2
• 化学式: C₁₈H₂₁NO
• 分子量: 267.371
• InChiKey: QKZLRKYRAYGYOV-UHFFFAOYSA-N

物化性质

• 熔点：
  229-230 °C(Solv: N,N-dimethylformamide (68-12-2))
• 沸点：
  433.5±34.0 °C(Predicted)
• 密度：
  1.045±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.28
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4'-戊基-4-联苯甲酰胺 、 三氯氧磷 以92%的产率得到
  参考文献：
  名称：

  OH C. S., LIQUID CRYST. AND ORDERED FLUIDS. SELEC. PAP. SYMP. DIV. COLLOID AND SURF+

  摘要：

  DOI：
• 作为产物：
  描述：

  4'-正戊基-4-氰基联苯 在 C₂₀H₂₁Cl₂OPRu 、 polyoxyethylene⁽⁸⁾isooctyl cyclohexyl ether 、 水 作用下， 反应 24.0h， 以89%的产率得到4'-戊基-4-联苯甲酰胺
  参考文献：
  名称：

  Efficient nitrile hydration mediated by RuII catalysts in micellar media

  摘要：

  在水中使用低溶解度的[RuCl2(η6-arene)(PR3)]催化剂1，通过表面活性剂的辅助，观察到高效的腈水合反应生成相应的酰胺衍生物，以确保底物和催化剂的溶解性，并能够对催化活性进行配体效应研究。使用优化的催化剂系统[RuCl2(p-cymene)(PPh2OEt)]/Triton X-114，观察到多种芳香族和脂肪族腈的酰胺产率在40%到95%之间。催化剂的分离和回收是可行的。

  DOI：

  10.1039/b924244a

文献信息

• ADAMSKA G.; DABROWSKI R.; DZIADUSZEK J.; KENIG K.; ZYTYNSKI E., BIUL. WAT J. DABROWSKIEGO, 1978, 27, NO 11, 91-102
  作者：ADAMSKA G.、 DABROWSKI R.、 DZIADUSZEK J.、 KENIG K.、 ZYTYNSKI E.

  DOI：——

  日期：——
• BIO-ASSAY USING LIQUID CRYSTALS
  申请人：Yang Kun-Lin

  公开号：US20110200986A1

  公开（公告）日：2011-08-18

  There is provided a method, an in vitro method and a detection system for detecting the presence of at least one biological molecule in at least one sample. The method can include, for example, providing a sample and/or a binding agent to a contact portion of a surface by way of at least one microfluidic channel; disposing a liquid crystal at the contact portion; determining whether the orientation of the liquid crystal changes after the sample contacts the binding agent, indicating the presence of the biological molecule; and determining length of bright region of the liquid crystal and/or change in interference color of said liquid crystal, and consequently indicating the quantity of said biological molecule. Also disclosed are methods of detecting biological molecules using at least one 4′-pentyl-biphenyl-4-R, where R may be at least one functional group selected from carboxylic acid, amine, aldehyde, and oligopeptide.
• [EN] BIO-ASSAY USING LIQUID CRYSTALS<br/>[FR] DOSAGE BIOLOGIQUE UTILISANT DES CRISTAUX LIQUIDES
  申请人：UNIV SINGAPORE

  公开号：WO2010042070A1

  公开（公告）日：2010-04-15

  The presence and/or quantity of a biological molecule is detected via the change in orientation of a liquid crystal, after a sample is contacted with a binding agent on a substrate (12). The length of a bright region or a change in interference colour of the liquid crystal is detected. The substrate may have a hydrophilic layer with embossed microfluidic channels (20), which is removed after transporting the sample and/or binding agent, and the substrate used to form part of a liquid crystal cell. Detection of a biological molecule may alternatively use 4'-pentyl-biphenyl- 4-R, wherein R is at least one functional group selected from carboxylic acid, amine, aldehyde and oligopeptide. For example, 4-cyano-4'-pentylbiphenyl (5CB) doped with 4'-pentyl-biphenyl-4-carboxylic acid (PBA) allows a change in pH of 0.1 or more to be detected due to contacting a sample with a binding agent. The biological molecule may be an enzyme such as penicillinase.