N-5-(4-hydroxy-3-methoxyphenyl)-2E-pentenoyl piperidine | 77795-17-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: N-5-(4-hydroxy-3-methoxyphenyl)-2E-pentenoyl piperidine
• 英文别名: (E)-5-(4-hydroxy-3-methoxy-phenyl)-1-(1-piperidyl)pent-2-en-1-one；(E)-5-(4-hydroxy-3-methoxyphenyl)-1-piperidin-1-ylpent-2-en-1-one
• CAS: 77795-17-6
• 化学式: C₁₇H₂₃NO₃
• 分子量: 289.375
• InChiKey: VHTQQWCWSZHGTL-XBXARRHUSA-N

物化性质

• 沸点：
  511.8±38.0 °C(Predicted)
• 密度：
  1.134±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-(溴乙酰基)哌啶 在 盐酸 、 sodium ethanolate 作用下， 以 乙醇 、 溶剂黄146 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.5h， 生成 N-5-(4-hydroxy-3-methoxyphenyl)-2E-pentenoyl piperidine
  参考文献：
  名称：

  Inatani, Reiko; Nakatani, Nobuji; Fuwa, Hidetsugu, Agricultural and Biological Chemistry, 1981, vol. 45, # 3, p. 667 - 674

  摘要：

  DOI：

文献信息

• METHYL MENTHOL DERIVATIVE AND COOLING AGENT COMPOSITION CONTAINING SAME
  申请人：TAKASAGO INTERNATIONAL CORPORATION

  公开号：US20180057447A1

  公开（公告）日：2018-03-01

  The purpose of the present invention is to provide a cooling agent composition containing a novel methyl menthol derivative having no undesirable feeling of stimulation, malodor, bitterness, or the like, it being possible to use the cooling agent composition as a cooling agent or sensory stimulation agent having exceptional persistence of a sense of coolness and refreshing feeling. The present invention pertains to a cooling agent composition containing a methyl menthol derivative represented by general formula (1A) or general formula (1B).

  本发明的目的是提供一种冷却剂组合物，其中包含一种新型的甲基薄荷醇衍生物，不具有刺激感、恶臭、苦味等不良感觉，可以将该冷却剂组合物用作具有出色持久感觉的凉爽和清新感的冷却剂或感官刺激剂。本发明涉及一种含有由通式（1A）或通式（1B）表示的甲基薄荷醇衍生物的冷却剂组合物。
• COOL-SENSATION IMPARTER COMPOSITION CONTAINING 2,2,6-TRIMETHYLCYCLOHEXANECARBOXYLIC ACID DERIVATIVE
  申请人：TAKASAGO INTERNATIONAL CORPORATION

  公开号：US20200297607A1

  公开（公告）日：2020-09-24

  A cooling agent composition contains a 2,2,6-trimethylcyclohexanecarboxylic acid derivative represented by the following general formula (1). The symbol * represents an asymmetric carbon atom. X represents NH, N(ZAr 2 ), O or S, Z represents a single bond or an alkylene group having 1 to 3 carbon atoms which may have a substituent, Ar 2 represents an aryl group having 6 to 20 carbon atoms which may have a substituent or an aromatic heterocyclic group having 2 to 15 carbon atoms which may have a substituent. Y each independently represents a methylene group which may have a substituent, and n represents an integer of 0 to 3. Ar 1 represents an aryl group having 6 to 20 carbon atoms which may have a substituent or an aromatic heterocyclic group having 2 to 15 carbon atoms which may have a substituent.

  一个制冷剂组合物包含一个由以下通用式（1）表示的2,2,6-三甲基环己烷羧酸衍生物。符号*代表一个不对称碳原子。X代表NH，N(ZAr2)，O或S，Z代表一个单键或一个具有1到3个碳原子的烷基基团，可以有一个取代基，Ar2代表一个具有6到20个碳原子的芳基基团，可以有一个取代基或一个具有2到15个碳原子的芳香杂环基团，可以有一个取代基。Y各自独立地表示一个可以有取代基的亚甲基基团，n表示0到3的整数。Ar1代表一个具有6到20个碳原子的芳基基团，可以有一个取代基或一个具有2到15个碳原子的芳香杂环基团，可以有一个取代基。
• Peroxisome Proliferator-Activated Receptor Ligand
  申请人：Kitano Mitsuaki

  公开号：US20080132544A1

  公开（公告）日：2008-06-05

  An object of the present invention is to provide a peroxisome proliferator-activated receptor γ (PPARγ) ligand derived from a natural product and to provide a composition for prevention or improvement of insulin resistant syndrome, diabetes mellitus, obesity, or visceral fat obesity, characterized by comprising the ligand as an active ingredient. The present invention provides a PPARγ ligand comprising as an active ingredient, at least one compound selected from the group consisting of coumaperine and derivatives thereof. The present invention also provides a composition for prevention or improvement of insulin resistant syndrome, diabetes mellitus, obesity, or visceral fat obesity comprising the compound as an active ingredient.

  本发明的目的是提供一种来自天然产物的过氧化物酶体增殖物激活受体γ（PPARγ）配体，并提供一种包含该配体作为活性成分的用于预防或改善胰岛素抵抗综合征、糖尿病、肥胖或内脏脂肪肥胖的组合物。本发明提供一种PPARγ配体，其包含至少选自库马佩林及其衍生物组的一种化合物作为活性成分。本发明还提供一种包含该化合物作为活性成分的用于预防或改善胰岛素抵抗综合征、糖尿病、肥胖或内脏脂肪肥胖的组合物。
• Method for evaluating sensory stimulus component
  申请人：Takasago International Corporation

  公开号：EP2642287A2

  公开（公告）日：2013-09-25

  A method for evaluating a sensory stimulus component in a test component with a taste-analyzing liquid chromatograph system. The method includes: measuring the test component with the taste-analyzing liquid chromatograph system to obtain taste evaluation data; and evaluating a persistence of a sensory stimulus intensity of the test component from a continuous intensity change of the test component using the taste evaluation data as an index.

  一种利用味觉分析液相色谱仪系统评估测试成分中感官刺激成分的方法。该方法包括：用味觉分析液相色谱仪系统测量测试成分，以获得味觉评估数据；以及以味觉评估数据为指标，从测试成分的连续强度变化中评估测试成分感官刺激强度的持续性。
• FLAVOR-IMPROVING AGENT
  申请人：Takasago International Corporation

  公开号：EP3225115A1

  公开（公告）日：2017-10-04

  The present invention provides a flavor-improving agent comprising an extract from a plant of the genus Quercus of the family Fagaceae, wherein the ratio of whisky lactone content to total polyphenol content is 0.2% or higher; and a method for the manufacture thereof.

  本发明提供了一种风味改进剂，它由一种栎科栎属植物的提取物组成，其中威士忌内酯含量与总多酚含量之比为 0.2% 或更高；本发明还提供了一种制造方法。