2,2-bis(4-bromophenyl)-1-(4-chlorophenyl)ethanone | 1259025-03-0

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 2,2-bis(4-bromophenyl)-1-(4-chlorophenyl)ethanone
• 英文别名: 2,2-Bis(4-bromophenyl)-1-(4-chlorophenyl)ethanone
• CAS: 1259025-03-0
• 化学式: C₂₀H₁₃Br₂ClO
• 分子量: 464.584
• InChiKey: BHKFPUGCPWIBSW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  二(4-溴苯基)甲醇 在 乙酰溴 、 3-mesityl-5,6,7,8-tetrahydro-4H-cyclohepta[d]thiazol-3-ium perchlorate 、 caesium carbonate 作用下， 以 四氢呋喃 、 苯 为溶剂， 反应 9.0h， 生成 2,2-bis(4-bromophenyl)-1-(4-chlorophenyl)ethanone
  参考文献：
  名称：

  N-Heterocyclic Carbene-Catalyzed Cross-Coupling of Aromatic Aldehydes with Activated Alkyl Halides

  摘要：

  N-Heterocyclic carbene-catalyzed umpolung of aldehydes followed by their interception with diarylbromomethanes has been reported. This conceptually novel transition-metal-free cross-coupling of aldehydes with alkyl halides works well at low catalyst loadings and under mild reaction conditions leading to the formation of diaryl acetophenone derivatives in good yields. In addition, a-halo ketones and esters can also be used, as aldehyde reaction partners.

  DOI：

  10.1021/ol102626p

文献信息

• N-Heterocyclic Carbene-Catalyzed Cross-Coupling of Aromatic Aldehydes with Activated Alkyl Halides
  作者：Mohan Padmanaban、Akkattu T. Biju、Frank Glorius

  DOI：10.1021/ol102626p

  日期：2011.1.7

  N-Heterocyclic carbene-catalyzed umpolung of aldehydes followed by their interception with diarylbromomethanes has been reported. This conceptually novel transition-metal-free cross-coupling of aldehydes with alkyl halides works well at low catalyst loadings and under mild reaction conditions leading to the formation of diaryl acetophenone derivatives in good yields. In addition, a-halo ketones and esters can also be used, as aldehyde reaction partners.