dimethyl (2E,4Z)-4-({[4-(phenylsulfamoyl)phenyl]amino}methylene)pent-2-enedioate | 1160499-39-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: dimethyl (2E,4Z)-4-({[4-(phenylsulfamoyl)phenyl]amino}methylene)pent-2-enedioate
• 英文别名: dimethyl (E,4Z)-4-[[4-(phenylsulfamoyl)anilino]methylidene]pent-2-enedioate
• CAS: 1160499-39-7
• 化学式: C₂₀H₂₀N₂O₆S
• 分子量: 416.455
• InChiKey: TUUFVCFJVMXGGU-VEEDHSDUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  29
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  119
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  dimethyl (2E,4Z)-4-({[4-(phenylsulfamoyl)phenyl]amino}methylene)pent-2-enedioate 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.05h， 以92%的产率得到methyl 2-oxo-1-[4-(phenylsulfamoyl)phenyl]-1,2-dihydropyridine-5-carboxylate
  参考文献：
  名称：

  Synthesis and Antimicrobial of Some Novel-5-carbomethoxy-2-pyridone Derivatives Containing Sulfonamide Moiety

  摘要：

  Dimethyl 4-(methoxymethylene)-2-pentenedioate 2 was selected as the starting material for the synthesis of some novel 2-pyridones containing sulfonamide moiety, which we expected to have biological activities such as bactericidal and fungicidal or other applications of certain interest.

  DOI：

  10.1080/10426500802067789
• 作为产物：
  描述：

  dimethyl 4-(methoxymethylene)-2-pentenedioate 、 磺胺苯 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.25h， 以80%的产率得到dimethyl (2E,4Z)-4-({[4-(phenylsulfamoyl)phenyl]amino}methylene)pent-2-enedioate
  参考文献：
  名称：

  Synthesis and Antimicrobial of Some Novel-5-carbomethoxy-2-pyridone Derivatives Containing Sulfonamide Moiety

  摘要：

  Dimethyl 4-(methoxymethylene)-2-pentenedioate 2 was selected as the starting material for the synthesis of some novel 2-pyridones containing sulfonamide moiety, which we expected to have biological activities such as bactericidal and fungicidal or other applications of certain interest.

  DOI：

  10.1080/10426500802067789

文献信息

• Synthesis and Antimicrobial of Some Novel-5-carbomethoxy-2-pyridone Derivatives Containing Sulfonamide Moiety
  作者：Fatma El-Mariah、Ekhlass Nassar

  DOI：10.1080/10426500802067789

  日期：2008.11.7

  Dimethyl 4-(methoxymethylene)-2-pentenedioate 2 was selected as the starting material for the synthesis of some novel 2-pyridones containing sulfonamide moiety, which we expected to have biological activities such as bactericidal and fungicidal or other applications of certain interest.