N-phthaloyl-1-(2,5-dimethoxyphenyl)-2-aminopropane | 30780-09-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: N-phthaloyl-1-(2,5-dimethoxyphenyl)-2-aminopropane
• 英文别名: N-[2-(2,5-dimethoxy-phenyl)-1-methyl-ethyl]-phthalimide；(+/-)-1-<2,5-Dimethoxy-phenyl>-2-phthalimido-propan；N-<1-(2,5-Dimethoxyphenyl)-2-propyl>-phthalimid；2-[1-(2,5-Dimethoxyphenyl)propan-2-yl]isoindole-1,3-dione
• CAS: 30780-09-7
• 化学式: C₁₉H₁₉NO₄
• 分子量: 325.364
• InChiKey: QRJOIMUUJSFFRM-UHFFFAOYSA-N

物化性质

• 沸点：
  477.1±35.0 °C(Predicted)
• 密度：
  1.235±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  55.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-phthaloyl-1-(2,5-dimethoxyphenyl)-2-aminopropane 在 氢溴酸 、 溴 作用下， 以 溶剂黄146 为溶剂， 反应 3.0h， 以100%的产率得到N-phthaloyl-1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane
  参考文献：
  名称：

  A structure-affinity study of the binding of 4-substituted analogs of 1-(2,5-dimethoxyphenyl)-2-aminopropane at 5-HT2 serotonin receptors

  摘要：

  With [3H]ketanserin as the radioligand, structure-affinity relationships (SAFIRs) for binding at central 5-HT2 serotonin receptors (rat frontal cortex) were examined for a series of 27 4-substituted 1-(2,5-dimethoxyphenyl)-2-aminopropane derivatives (2,5-DMAs). The affinity (Ki values) ranged over a span of several orders of magnitude. It appears that the lipophilic character of the 4-position substituent plays a major role in determining the affinity of these agents for 5-HT2 receptors, 2,5-DMAs with polar 4-substituents (e.g. OH, NH2, COOH) display a very low affinity (Ki greater than 25,000 nM) for these receptors, whereas those with lipophilic functions display a significantly higher affinity. The results of these studies prompted us to synthesize and evaluate examples of newer lipophilic derivatives and several of these (e.g. n-hexyl, n-octyl) bind with very high (Ki values = 2.5 and 3 nM, respectively) affinities at central 5-HT2 sites. Although, 2,5-DMAs are generally considered to be 5-HT2 agonists, preliminary studies with isolated rat thoracic aorta suggest that some of the more lipophilic derivatives (e.g. the n-hexyl and n-octyl derivatives) are 5-HT2 antagonists.

  DOI：

  10.1021/jm00165a023

文献信息

• A structure-affinity study of the binding of 4-substituted analogs of 1-(2,5-dimethoxyphenyl)-2-aminopropane at 5-HT2 serotonin receptors
  作者：Mark R. Seggel、M. Y. Yousif、Robert A. Lyon、Milt Titeler、Bryan L. Roth、Eva A. Suba、Richard A. Glennon

  DOI：10.1021/jm00165a023

  日期：1990.3

  With [3H]ketanserin as the radioligand, structure-affinity relationships (SAFIRs) for binding at central 5-HT2 serotonin receptors (rat frontal cortex) were examined for a series of 27 4-substituted 1-(2,5-dimethoxyphenyl)-2-aminopropane derivatives (2,5-DMAs). The affinity (Ki values) ranged over a span of several orders of magnitude. It appears that the lipophilic character of the 4-position substituent plays a major role in determining the affinity of these agents for 5-HT2 receptors, 2,5-DMAs with polar 4-substituents (e.g. OH, NH2, COOH) display a very low affinity (Ki greater than 25,000 nM) for these receptors, whereas those with lipophilic functions display a significantly higher affinity. The results of these studies prompted us to synthesize and evaluate examples of newer lipophilic derivatives and several of these (e.g. n-hexyl, n-octyl) bind with very high (Ki values = 2.5 and 3 nM, respectively) affinities at central 5-HT2 sites. Although, 2,5-DMAs are generally considered to be 5-HT2 agonists, preliminary studies with isolated rat thoracic aorta suggest that some of the more lipophilic derivatives (e.g. the n-hexyl and n-octyl derivatives) are 5-HT2 antagonists.