3-(2-methoxy-phenyl)-2-methyl-propionic acid ethyl ester | 1014984-96-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-(2-methoxy-phenyl)-2-methyl-propionic acid ethyl ester
• 英文别名: 3-(2-Methoxy-phenyl)-2-methyl-propionsaeure-aethylester；ethyl 3-(2-methoxyphenyl)-2-methylpropanoate
• CAS: 1014984-96-3
• 化学式: C₁₃H₁₈O₃
• 分子量: 222.284
• InChiKey: GDXOQDPOMMVXJV-UHFFFAOYSA-N

物化性质

• 沸点：
  292.3±15.0 °C(Predicted)
• 密度：
  1.028±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(2-methoxy-phenyl)-2-methyl-propionic acid ethyl ester 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 2.0h， 生成 3-(2-methoxyphenyl)-2-methylpropan-1-ol
  参考文献：
  名称：

  氢化钠/碘化物复合物促进的甲氧基芳烃的亲核胺化

  摘要：

  围成一圈：在碘化锂（LiI）存在下，使用氢化钠（NaH）建立了甲氧基芳烃的亲核胺化方法。该方法提供了一条有效的途径来制得二环氮杂环。机理研究表明，该反应通过异常的协同的亲核芳族取代进行。

  DOI：

  10.1002/anie.201705916
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 镍 作用下， 生成 3-(2-methoxy-phenyl)-2-methyl-propionic acid ethyl ester
  参考文献：
  名称：

  Mastagli; Lambert, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1951, vol. 233, p. 751

  摘要：

  DOI：

文献信息

• MACROCYCLIC GHRELIN RECEPTOR MODULATORS AND METHODS OF USING THE SAME
  申请人：Hoveyda Hamid

  公开号：US20080194672A1

  公开（公告）日：2008-08-14

  The present invention provides novel conformationally-defined macrocyclic compounds that can function as selective modulators of the ghrelin receptor (growth hormone secretagogue receptor, GHS-R1a and subtypes, isoforms and variants thereof). Methods of synthesizing the novel compounds are also described herein. These compounds are useful as agonists of the ghrelin receptor and as medicaments for treatment and prevention of a range of medical conditions including, but not limited to, metabolic and/or endocrine disorders, gastrointestinal disorders, cardiovascular disorders, obesity and obesity-associated disorders, central nervous system disorders, bone disorders, genetic disorders, hyperproliferative disorders and inflammatory disorders.

  本发明提供了一种新颖的构象定义明确的大环化合物，可以作为生长激素分泌素受体（GHS-R1a及其亚型、异构体和变体）的选择性调节剂。本文还描述了合成这些新型化合物的方法。这些化合物可用作生长激素分泌素受体的激动剂，用于治疗和预防一系列医疗状况，包括但不限于代谢和/或内分泌紊乱、胃肠道紊乱、心血管疾病、肥胖和与肥胖相关的疾病、中枢神经系统疾病、骨骼疾病、遗传疾病、过度增生性疾病和炎症性疾病。
• MACROCYCLIC ANTAGONISTS OF THE MOTILIN RECEPTOR FOR TREATMENT OF GASTROINTESTINAL DYSMOTILITY DISORDERS
  申请人：Marsault Eric

  公开号：US20100093720A1

  公开（公告）日：2010-04-15

  The present invention provides conformationally-defined macrocyclic compounds that bind to and/or are functional modulators of the motilin receptor including subtypes, isoforms and/or variants thereof. These macrocyclic compounds, at a minimum, possess adequate pharmacological properties to be useful as therapeutics for a range of disease indications. In particular, these compounds are useful for treatment and prevention of disorders characterized by hypermotilinemia and/or gastrointestinal hypermotility, including, but not limited to, diarrhea, cancer treatment-related diarrhea, cancer-induced diarrhea, chemotherapy-induced diarrhea, radiation enteritis, radiation-induced diarrhea, stress-induced diarrhea, chronic diarrhea, AIDS-related diarrhea, C. difficile associated diarrhea, traveller's diarrhea, diarrhea induced by graph versus host disease, other types of diarrhea, dyspepsia, irritable bowel syndrome, chemotherapy-induced nausea and vomiting (emesis) and post-operative nausea and vomiting and functional gastrointestinal disorders. In addition, the compounds possess utility for the treatment of diseases and disorders characterized by poor stomach or intestinal absorption, such as short bowel syndrome, celiac disease and cachexia. The compounds also have use for the treatment of inflammatory diseases and disorders of the gastrointestinal tract, such as inflammatory bowel disease, ulcerative colitis, Crohn's disease and pancreatitis. Accordingly, methods of treating such disorders and pharmaceutical compositions including compounds of the present invention are also provided.

  本发明提供了与胃动素受体及其亚型、异构体和/或变体结合和/或是功能调节剂的构象定义明确的大环化合物。这些大环化合物至少具有足够的药理特性，可用作治疗一系列疾病指示的治疗药物。特别是，这些化合物对于治疗和预防以高胃动素血症和/或胃肠道高蠕动性为特征的疾病非常有用，包括但不限于腹泻、癌症治疗相关腹泻、癌症诱导腹泻、化疗诱导腹泻、放射性肠炎、放射性腹泻、压力诱导腹泻、慢性腹泻、艾滋病相关腹泻、C. difficile相关腹泻、旅行者腹泻、移植物宿主病引起的腹泻、其他类型的腹泻、消化不良、肠易激综合征、化疗诱导的恶心和呕吐（呕吐）以及术后恶心和呕吐和功能性胃肠道疾病。此外，这些化合物对于治疗以胃或肠道吸收不良为特征的疾病和疾病也具有用途，例如短肠综合征、乳糜泻和虚弱。这些化合物还可用于治疗胃肠道炎症性疾病和疾病，如炎症性肠病、溃疡性结肠炎、克罗恩病和胰腺炎。因此，本发明还提供了治疗此类疾病的方法和包括本发明化合物的药物组合物。
• Macrocyclic antagonist of the motilin receptor for treatment of gastrointestinal dysmotility disorders
  申请人：Tranzyme Pharma, Inc.

  公开号：EP2431380A2

  公开（公告）日：2012-03-21

  The present invention provides conformationally-defined macrocyclic compounds that bind to and/or are functional modulators of the motilin receptor including subtypes, isoforms and/or variants thereof. These macrocyclic compounds, at a minimum, possess adequate pharmacological properties to be useful as therapeutics for a range of disease indications. In particular, these compounds are useful for treatment and prevention of disorders characterized by hypermotilinemia and/or gastrointestinal hypermotility, including, but not limited to, diarrhea, cancer treatment-related diarrhea, cancer-induced diarrhea, chemotherapy-induced diarrhea, radiation enteritis, radiation-induced diarrhea, stress-induced diarrhea, chronic diarrhea, AIDS-related diarrhea, C. difficile associated diarrhea, traveller's diarrhea, diarrhea induced by graph versus host disease, other types of diarrhea, dyspepsia, irritable bowel syndrome, chemotherapy-induced nausea and vomiting (emesis) and post-operative nausea and vomiting and functional gastrointestinal disorders. In addition, the compounds possess utility for the treatment of diseases and disorders characterized by poor stomach or intestinal absorption, such as short bowel syndrome, celiac disease and cachexia. The compounds also have use for the treatment of inflammatory diseases and disorders of the gastrointestinal tract, such as inflammatory bowel disease, ulcerative colitis, Crohn's disease and pancreatitis. Accordingly, methods of treating such disorders and pharmaceutical compositions including compounds of the present invention are also provided.

  本发明提供了与动情素受体（包括其亚型、同工型和/或变体）结合和/或作为其功能调节剂的构象明确的大环化合物。这些大环化合物至少具有足够的药理特性，可作为一系列疾病适应症的治疗药物。特别是，这些化合物可用于治疗和预防以高胰岛素血症和/或胃肠道高运动性为特征的疾病，包括但不限于腹泻、癌症治疗相关性腹泻、癌症诱导性腹泻、化疗诱导性腹泻、放射性肠炎、放射性诱导性腹泻、压力诱导性腹泻、慢性腹泻、艾滋病相关性腹泻、艰难梭菌相关性腹泻、C.腹泻、艰难梭菌相关性腹泻、旅行者腹泻、图形对宿主疾病诱发的腹泻、其他类型的腹泻、消化不良、肠易激综合征、化疗诱发的恶心和呕吐（呃逆）、术后恶心和呕吐以及功能性胃肠功能紊乱。此外，这些化合物还可用于治疗以胃或肠吸收不良为特征的疾病和失调，如短肠综合征、乳糜泻和恶病质。这些化合物还可用于治疗胃肠道炎症性疾病和紊乱，如炎症性肠病、溃疡性结肠炎、克罗恩病和胰腺炎。因此，还提供了治疗此类疾病的方法和包括本发明化合物的药物组合物。
• Catalyst components for the polymerization of olefins
  申请人：Basell Poliolefine Italia S.r.l.

  公开号：EP2583985A1

  公开（公告）日：2013-04-24

  Catalyst component for the polymerization of olefins comprising Mg, Ti and an electron donor compound of the following formula (I) In which R to R4 groups, equal to or different from each other, are hydrogen, halogen or C1-C15 hydrocarbon groups, optionally containing an heteroatom selected from halogen, P, S, N and Si, which may be linked to form a saturated or unsaturated mono or polycycle and R5 groups, are selected from C1-C15 hydrocarbon groups optionally containing an heteroatom selected from halogen, P, S, N and Si.

  用于烯烃聚合的催化剂组分，由 Mg、Ti 和下式 (I) 的电子供体化合物组成 其中 R 至 R4 基团（彼此相等或不同）为氢、卤素或 C1-C15 烃基，可选择含有选自卤素、P、S、N 和 Si 的杂原子，它们可连接形成饱和或不饱和单环或多环及 R5 基团，可选择含有选自卤素、P、S、N 和 Si 的杂原子的 C1-C15 烃基。
• tether intermediates for the synthesis of macrocyclic ghrelin receptor modulators
  申请人：Tranzyme Pharma, Inc.

  公开号：EP2644618A1

  公开（公告）日：2013-10-02

  The present invention relates to intermediates of conformationally-defined macrocyclic compounds that bind to and/or are functional modulators of the ghrelin (growth hormone secretagogue) receptor including GHS-R1a and subtypes, isoforms and/or variants thereof and the use of these interemdaites to prepare said macrocyclic compounds.

  本发明涉及与胃泌素（生长激素分泌物）受体（包括 GHS-R1a 及其亚型、同工型和/或变体）结合和/或作为其功能调节剂的构象定义大环化合物的中间体，以及使用这些中间体制备所述大环化合物。