4-(2-氯-丙基)-苯甲醚 | 4125-46-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-(2-氯-丙基)-苯甲醚
• 英文名称: 1-(2-chloropropyl)-4-methoxybenzene
• CAS: 4125-46-6
• 化学式: C₁₀H₁₃ClO
• 分子量: 184.666
• InChiKey: MGPAUSDSYCQMJR-UHFFFAOYSA-N

物化性质

• 沸点：
  107 °C(Press: 5 Torr)
• 密度：
  1.0891 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-(2-氯-丙基)-苯甲醚 在 乙醇 、 氨 作用下， 生成 1-(4-甲氧基苄基)乙胺
  参考文献：
  名称：

  芳基丙胺的合成；来自烯丙基氯。

  摘要：

  DOI：

  10.1021/ja01210a032
• 作为产物：
  描述：

  1-(4-甲氧基苯基)丙-2-醇 在 氯化亚砜 作用下， 生成 4-(2-氯-丙基)-苯甲醚
  参考文献：
  名称：

  Stable carbonium ions. XXXI. p-Anisonium and methylphenonium ion-formation via aryl participation in strong acid solution

  摘要：

  DOI：

  10.1021/ja00996a031

文献信息

• Metal-free regioselective hydrochlorination of unactivated alkenes<i>via</i>a combined acid catalytic system
  作者：Shengzong Liang、Gerald B. Hammond、Bo Xu

  DOI：10.1039/c7gc03665e

  日期：——

  A combined acid HCl/DMPU-acetic acid catalytic system was used in the hydrochlorination of a wide range of unactivated alkenes.

  一个结合了盐酸/HCl、DMPU和乙酸的催化体系被用于对一系列未活化的烯烃进行氯化反应。
• Silica gel-mediated hydrohalogenation of unactivated alkenes using hydrohalogenic acids under organic solvent-free conditions
  作者：Kiyoshi Tanemura

  DOI：10.1016/j.tetlet.2018.10.043

  日期：2018.12

  Silica gel-mediated hydrochlorination of unactivated alkenes using 35% hydrochloric acid under organic solvent-free conditions proceeded to give the corresponding chlorides in good yields. Hydrobromination or hydriodination using 47% hydrobromic acid or 55% hydriodic acid afforded the corresponding halides, respectively. Silica gel could be recycled five times without any significant loss of activities

  在无有机溶剂的条件下，使用35％盐酸进行硅胶介导的未活化烯烃的氢氯化反应，得到了相应的氯化物，收率很高。使用47％氢溴酸或55％氢碘酸进行氢溴化或氢碘化分别得到相应的卤化物。硅胶可以循环使用五次，而不会造成任何明显的活性损失。
• Organic Bismuth Compound, Method for Producing Same, Living Radical Polymerization Initiator, Method for Producing Polymer Using Same, and Polymer
  申请人：Yamago Shigeru

  公开号：US20070265404A1

  公开（公告）日：2007-11-15

  An organobismuth compound represented by the formula (1) wherein R 1 and R 2 are C 1 -C 8 alkyl, aryl, substituted aryl or an aromatic heterocyclic group, R 3 and R 4 are each a hydrogen atom or C 1 -C 8 alkyl, and R 5 is aryl, substituted aryl, an aromatic heterocyclic group, acyl, amido, oxycarbonyl or cyano.

  一种有机铋化合物，其化学式为(1)，其中R1和R2为C1-C8烷基、芳基、取代芳基或芳香族杂环基，R3和R4分别为氢原子或C1-C8烷基，R5为芳基、取代芳基、芳香族杂环基、酰基、酰胺基、氧羰基或氰基。
• Hydrochlorination of Alkenes with Hydrochloric Acid
  作者：Arnaud Olivier、Daniel S. Müller

  DOI：10.1021/acs.oprd.3c00418

  日期：2024.1.19

  The hydrochlorination of alkenes with hydrogen chloride gas is typically limited to activated olefins. Herein, we present an innovative hydrochlorination approach utilizing hydrochloric acid within vigorously agitated solutions. Notably, the introduction of acetic acid was found to enhance the reaction rate. We substantiated the practicality of our method by conducting the hydrochlorination of styrene

  用氯化氢气体进行的烯烃氢氯化通常仅限于活化烯烃。在此，我们提出了一种创新的氢氯化方法，在剧烈搅拌的溶液中利用盐酸。值得注意的是，发现乙酸的引入提高了反应速率。我们通过在 1 摩尔规模上进行苯乙烯氢氯化反应，产率 96%，证实了我们方法的实用性。
• Effect of Low-Fat and/or Low-Energy Diets on Anthropometric Measures in Participants of the Women’s Diet Study
  作者：Zora Djuric、Samir Lababidi、Lance K. Heilbrun、Janice B. Depper、Kathleen M. Poore、Virginia E. Uhley

  DOI：10.1080/07315724.2002.10719192

  日期：2002.2

  Objective: To compare the effects of low-fat, low-energy and combination low-fat/low-energy intervention on changes in six anthropometric measures in Caucasian and African-American free-living women.Methods: The effects of dietary counseling strategies for fat and/or energy reduction were examined on anthropometric measures in 86 pre-menopausal women, average BMI of 28 kg/m(2), who participated in a 12-week intervention trial called the Women's Diet Study. The dietary goals were 1510 of energy from fat and/or 25% reduction in energy intake, relative to reported baseline intake, using a 2 x 2 factorial design. Analysis of covariance models were constructed to evaluate changes in anthropometric measures over the 12 weeks of study.Results: The biggest difference by race was in women who were relatively heavier at baseline, in which case African-American women lost significantly less weight but decreased their waist:hip ratio to a significantly greater extent than Caucasian women. With regard to the effects of diet arm, weight loss varied depending on baseline weight, and in women with higher baseline weights, the combination low-fat/low-energy diet resulted in the most weight loss (6.7 kg, p < 0.05). Decreases in the other anthropometric measures at week 12 were more uniform across diet arms and did not depend on baseline values. After controlling for previous weight history and race, the decreases in BMI, percent body fat and waist circumference after 12 weeks were statistically equivalent with the low-fat, low-energy or combination low-fat/low-energy diets. The relatively greater decreases in percent body fat and waist circumference with the combination diet versus the low-fat or low-energy diets were not statistically significant.Conclusion: The low-fat, low-energy and combination diets all resulted in similar and statistically significant decreases in BMI, percent body fat and waist circumference over 12 weeks of intervention. The extent of weight loss, however, varied depending on baseline weight, and the combination diet was the only intervention to result in significant weight loss for women who were heavier at baseline. This indicates that, although there may be an advantage for reducing dietary fat in initially heavier women, any of these counseling strategies could be effective for improving anthropometric predictors of health risks associated with overweight status. This is useful since flexibility in dietary choices may facilitate adherence to dietary counseling in some individuals.