(3R)-15-methyl-N-[(2R,3R)-15-methyl-3-phenylmethoxy-1-sulfanylhexadecan-2-yl]-3-phenylmethoxyhexadecanamide | 942137-34-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (3R)-15-methyl-N-[(2R,3R)-15-methyl-3-phenylmethoxy-1-sulfanylhexadecan-2-yl]-3-phenylmethoxyhexadecanamide
• CAS: 942137-34-0
• 化学式: C₄₈H₈₁NO₃S
• 分子量: 752.242
• InChiKey: IXLUQEGXULJDKS-WAFODNFBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  16.5
• 重原子数：
  53
• 可旋转键数：
  35
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  48.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (3R)-15-methyl-N-[(2R,3R)-15-methyl-3-phenylmethoxy-1-sulfanylhexadecan-2-yl]-3-phenylmethoxyhexadecanamide 在 palladium on activated charcoal 氢气 、 双氧水 、 三氟乙酸 作用下， 以 乙醇 为溶剂， 生成 (2R,3R,3'R)-3-hydroxy-2-(3'-hydroxy-15'-methylhexadecanoylamino)-15-methyl-hexadecan-1-sulfonic acid
  参考文献：
  名称：

  An asymmetric synthesis of sulfobacin A

  摘要：

  A facile synthesis of sulfobacin A has been developed starting from (R)-cyclohexylideneglyceraldehyde (11). The key steps in the synthesis are the highly diastereocontrolled allylation of 11 and syn-selective reduction of a ketone derived from 11. The other attractive features are the operational simplicity and the use of inexpensive compounds/reagents. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.03.115
• 作为产物：
  描述：

  S-[(2R,3R)-15-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylmethoxyhexadecyl] ethanethioate 在 盐酸 、 lithium aluminium tetrahydride 作用下， 以 1,4-二氧六环 、 乙醚 为溶剂， 生成 (3R)-15-methyl-N-[(2R,3R)-15-methyl-3-phenylmethoxy-1-sulfanylhexadecan-2-yl]-3-phenylmethoxyhexadecanamide
  参考文献：
  名称：

  An asymmetric synthesis of sulfobacin A

  摘要：

  A facile synthesis of sulfobacin A has been developed starting from (R)-cyclohexylideneglyceraldehyde (11). The key steps in the synthesis are the highly diastereocontrolled allylation of 11 and syn-selective reduction of a ketone derived from 11. The other attractive features are the operational simplicity and the use of inexpensive compounds/reagents. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2007.03.115

文献信息

• An asymmetric synthesis of sulfobacin A
  作者：Anubha Sharma、Sunita Gamre、Subrata Chattopadhyay

  DOI：10.1016/j.tetlet.2007.03.115

  日期：2007.5

  A facile synthesis of sulfobacin A has been developed starting from (R)-cyclohexylideneglyceraldehyde (11). The key steps in the synthesis are the highly diastereocontrolled allylation of 11 and syn-selective reduction of a ketone derived from 11. The other attractive features are the operational simplicity and the use of inexpensive compounds/reagents. (c) 2007 Elsevier Ltd. All rights reserved.