2-(2-amino-phenyl)-N,N-dimethyl-acetamide | 86162-60-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(2-amino-phenyl)-N,N-dimethyl-acetamide
• 英文别名: 2-(2-aminophenyl)-N,N-dimethylacetamide
• CAS: 86162-60-9
• 化学式: C₁₀H₁₄N₂O
• mdl: MFCD09739139
• 分子量: 178.234
• InChiKey: BHPJSFPAIYHSEA-UHFFFAOYSA-N

物化性质

• 沸点：
  346.7±25.0 °C(Predicted)
• 密度：
  1.100±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  46.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2924299090

反应信息

• 作为反应物：
  描述：

  4-氯-7-三氟甲基喹啉 、 2-(2-amino-phenyl)-N,N-dimethyl-acetamide 在 盐酸 作用下， 以 1,4-二氧六环 、 乙腈 为溶剂， 生成 N,N-dimethyl-2-[2-(7-trifluoromethyl-quinolin-4-ylamino)-phenyl]-acetamide hydrochloride
  参考文献：
  名称：

  WO2008/48577

  摘要：

  公开号：
• 作为产物：
  描述：

  N,N-dimethyl-o-nitrophenylacetamide 在 5%-palladium/activated carbon 氢气 作用下， 以 甲醇 为溶剂， 生成 2-(2-amino-phenyl)-N,N-dimethyl-acetamide
  参考文献：
  名称：

  WO2008/48577

  摘要：

  公开号：

文献信息

• METHODS OF USING 4-PHENYLAMINOQUINOLINES AS TOPICAL NON-STEROIDAL ANTIINFLAMMATORY COMPOUNDS
  申请人：Wasley Jan

  公开号：US20080139611A1

  公开（公告）日：2008-06-12

  A skin disorder, a disorder associated with pain, fever, or inflammation, a proliferative disorder, or an ocular disorder is treated by topically administering a pharmaceutically acceptable formulation containing a therapeutically effective amount of a 4-phenylaminoquinoline compound.

  一种皮肤疾病、与疼痛、发热或炎症相关的疾病、增生性疾病或眼部疾病可通过局部给药含有治疗有效量4-苯胺基喹啉化合物的药学上可接受的制剂来治疗。
• EP3919479
  申请人：——

  公开号：——

  公开（公告）日：——
• Efficient solid-phase synthesis of 2,3-substituted indoles
  作者：Dean A Wacker、Padmaja Kasireddy

  DOI：10.1016/s0040-4039(02)01025-0

  日期：2002.7

  The development of the solid-phase version of the modified Madelung indole synthesis is reported. The chemistry was initiated with the reductive amination of Bal resin using an ortho substituted aniline. The resin bound aniline was acylated with a variety of acid chlorides followed by cyclization with base to provide the desired indole after TFA-promoted cleavage from the resin. (C) 2002 Elsevier Science Ltd. All rights reserved.
• COMPOUND HAVING BENZO SEVEN-MEMBERED RING STRUCTURE, PREPARATION METHOD THEREFOR, AND USE THEREOF
  申请人：BIONNA (BEIJING) MEDICAL TECHNOLOGY CO., LTD.

  公开号：US20210380592A1

  公开（公告）日：2021-12-09

  The present invention relates to a compound having a benzo seven-membered ring structure, and a preparation method therefor, and use thereof. The compound has a structure as represented by formula (I). Provided is use of the compound having the structure and prepared with the preparation method of the present invention, enantiomers, diastereomers, racemates and mixtures thereof of the compound, as well as chemically acceptable salts, crystalline hydrates and solvent mixtures of the compound and the enantiomers, diastereomers, racemates and mixtures thereof of the compound in the preparation of drugs for treating BET Bromodomain BRD4 activity or expression level related diseases.
• [EN] METHODS OF USING 4-PHENYLAMINOQUINOLINES AS TOPICAL NON-STEROIDAL ANTIINFLAMMATORY COMPOUNDS<br/>[FR] PROCÉDÉS D'UTILISATION DE 4-PHÉNYLAMINOQUINOLINES EN TANT QUE COMPOSÉS TOPIQUES ANTI-INFLAMMATOIRES NON STÉROÏDES
  申请人：MILESTONE PHARMACEUTICALS INC

  公开号：WO2008048577A1

  公开（公告）日：2008-04-24

  [EN] A skin disorder, a disorder associated with pain, fever, or inflammation, a proliferative disorder, or an ocular disorder is treated by topically administering a pharmaceutically acceptable formulation containing a therapeutically effective amount of a 4-phenylaminoquinoline compound.
  [FR] L'invention permet de traiter une affection cutanée, une affection associée à la douleur, la fièvre ou l'inflammation, une affection proliférative ou une affection oculaire par l'administration topique d'une formulation pharmaceutiquement acceptable contenant une quantité thérapeutiquement efficace d'un composé à base de 4-phénylaminoquinolines