4-(aminosulfonyl)butyl acetate | 275384-11-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: 4-(aminosulfonyl)butyl acetate
• 英文别名: 4-acetoxybutanesulfonamide；4-sulfamoylbutyl acetate
• CAS: 275384-11-7
• 化学式: C₆H₁₃NO₄S
• 分子量: 195.24
• InChiKey: JCYYIBMYHYEVNG-UHFFFAOYSA-N

物化性质

• 沸点：
  335.0±44.0 °C(Predicted)
• 密度：
  1.253±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  94.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  N-tert-butyl-4-acetoxybutanesulfonamide 在 silica gel 、 氯仿 、 甲醇 作用下， 以 三氟乙酸 为溶剂， 反应 4.0h， 以to give 4-acetoxybutanesulfonamide (347 mg) as a brown oil的产率得到4-(aminosulfonyl)butyl acetate
  参考文献：
  名称：

  Sulfonamide compounds and uses thereof as medicines

  摘要：

  本发明涉及化合物(I)的磺酰胺，其公式如下：其中每个符号如规范中所定义，其盐和含有该化合物的药物组合物。该化合物可作为一种有效的药剂，用于预防和治疗基于降糖作用可治疗的疾病，以及基于cGMP-PDE抑制作用、平滑肌松弛作用、支气管扩张作用、血管扩张作用、平滑肌细胞抑制作用和抗过敏作用可治疗的疾病。

  公开号：

  US06890934B2

文献信息

• [EN] AMINOALCOHOL DERIVATIVES<br/>[FR] DERIVES D'AMINOALCOOL
  申请人：ASTELLAS PHARMA INC

  公开号：WO2006033446A1

  公开（公告）日：2006-03-30

  The present invention relates to a compound of the formula [I]: wherein (a), in which -Y-, R4, R5 and R6 are4 R5 each as defined in the description, etc., R1 is hydrogen, halogen, lower alkyl, hydroxy, etc., R2 is hydrogen, lower alkyl or hydroxy(lower)alkyl, R3 is hydrogen or an amino protective group, 20 R7 is hydrogen, lower alkyl, cyclo(lower)alkyl, lower R9 alkenyl, -Z-R9 or (b), in which -Z- is -0-, -S-, R9 -SO- or -SO2-, and each R9 is independently hydrogen, lower alkyl, cyclo(lower)alkyl, etc., and R8 is -D-E-R10, in which -D- is -CONHSO2- or -S02NHCO-, E is bond or lower alkylene, and R10 is halogen, cyano, carboxy, etc., or a prodrug thereof or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of ulcer, overactive bladder, and the like.

  本发明涉及一种具有以下结构的化合物[I]：其中（a）中的-Y-，R4，R5和R6分别如描述中定义，等等，R1为氢，卤素，低烷基，羟基等，R2为氢，低烷基或羟基（低）烷基，R3为氢或氨基保护基，R7为氢，低烷基，环（低）烷基，低R9烯基，-Z-R9或（b），其中-Z-为-0-，-S-，R9-SO-或-SO2-，每个R9独立地为氢，低烷基，环（低）烷基等，R8为-D-E-R10，其中-D-为-CONHSO2-或-S02NHCO-，E为键或低烷基，R10为卤素，氰基，羧基等，或其前药或盐。本发明的化合物[I]及其药学上可接受的盐对于预防和/或治疗溃疡，过度活跃的膀胱等疾病是有用的。
• Aminoalcohol Derivatives
  申请人：Hattori Kouji

  公开号：US20080039506A1

  公开（公告）日：2008-02-14

  The present invention relates to a compound of the formula [I]: wherein (a), in which —Y—, R 4 , R 5 and R 6 are 4 R 5 each as defined in the description, etc., R 1 is hydrogen, halogen, lower alkyl, hydroxy, etc., R 2 is hydrogen, lower alkyl or hydroxy(lower)alkyl, R 3 is hydrogen or an amino protective group, 20 R7 is hydrogen, lower alkyl, cyclo(lower)alkyl, lower R9 alkenyl, -Z-R 9 or (b), in which -Z- is -0-, —S—, R 9 —SO— or —SO 2 —, and each R 9 is independently hydrogen, lower alkyl, cyclo(lower)alkyl, etc., and R 8 is -D-E-R , in which -D- is —CONHSO 2 — or —S0 2 NHCO—, E is bond or lower alkylene, and R 10 is halogen, cyano, carboxy, etc., or a prodrug thereof or a salt thereof. The compound [I] of the present invention and pharmaceutically acceptable salts thereof are useful for the prophylactic and/or the therapeutic treatment of ulcer, overactive bladder, and the like.

  本发明涉及一种式[I]的化合物：其中（a）中，-Y-，R4，R5和R6与描述中定义的4R5等同，R1为氢，卤素，较低的烷基，羟基等，R2为氢，较低的烷基或羟基（较低的）烷基，R3为氢或氨基保护基，R7为氢，较低的烷基，环（较低的）烷基，较低的烯基，-Z-R9或（b）中，-Z-为-0-，-S-，R9-SO-或-SO2-，每个R9都是独立的氢，较低的烷基，环（较低的）烷基等，R8为-D-E-R，其中-D-为-CONHSO2-或-S02NHCO-，E为键或较低的亚烷基，R10为卤素，氰基，羧基等，或其前药或盐。本发明的化合物[I]及其药学上可接受的盐对于预防和/或治疗溃疡，过度活跃的膀胱等具有用途。
• SULFONAMIDE COMPOUNDS AND USES THEREOF AS MEDICINES
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP1136492A1

  公开（公告）日：2001-09-26

  The present invention relates to a sulfonamide compound of the formula (I): wherein each symbol is as defined in the specification, a salt thereof, and a pharmaceutical composition containing same. This compound can be an effective agent for the prophylaxis and treatment of the diseases curable based on a hypoglycemic action, and the diseases curable based on a cGMP-PDE inhibitory action, a smooth muscle relaxing action, a bronchodilating action, a vasodilating action, a smooth muscle cell inhibitory action and an allergy suppressing action.

  本发明涉及一种式 (I) 的磺酰胺化合物： 其中各符号如说明书中所定义的磺酰胺化合物、其盐和含有该化合物的药物组合物。该化合物可作为预防和治疗基于降血糖作用的疾病和基于 cGMP-PDE 抑制作用、平滑肌松弛作用、支气管扩张作用、血管扩张作用、平滑肌细胞抑制作用和过敏抑制作用的疾病的有效药物。
• AMINOALCOHOL DERIVATIVES
  申请人：Astellas Pharma Inc.

  公开号：EP1791811A1

  公开（公告）日：2007-06-06
• US6573274B1
  申请人：——

  公开号：US6573274B1

  公开（公告）日：2003-06-03