1-(3-Phenyl-1,2,4-triazin-5-yl)ethanone (4-methoxyphenyl)hydrazone

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(3-Phenyl-1,2,4-triazin-5-yl)ethanone (4-methoxyphenyl)hydrazone
• 英文别名: 4-methoxy-N-[(Z)-1-(3-phenyl-1,2,4-triazin-5-yl)ethylideneamino]aniline
• 化学式: C₁₈H₁₇N₅O
• 分子量: 319.366
• InChiKey: LZPOUAUGKDNMTR-BKUYFWCQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  72.3
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1-(3-Phenyl-1,2,4-triazin-5-yl)ethanone (4-methoxyphenyl)hydrazone 在 盐酸 作用下， 以 1,4-二氧六环 、 乙醇 为溶剂， 反应 2.0h， 以77%的产率得到1-(4-Methoxy-phenyl)-3-methyl-5-phenyl-1H-pyrazolo[4,3-e][1,2,4]triazine
  参考文献：
  名称：

  5-Acyl-1,2,4-三嗪苯腙酸促进闭环合成吡唑并[4,3-e][1,2,4]三嗪

  摘要：

  The reaction of various substituted phenylhydrazones of 5-acyl-1,2,4-triazines in the presence of 1.1 equivalent of HCl in boiling ethanol-dioxane mixture has been studied. In all reactions the formation of the corresponding pyrazolo[4,3-e][1,2,4]triazines (3a-r) takes place in good yield. The structures of 3a-r were unequivocally established by spectroscopic methods as well as by X-Ray analysis of selected 5-methyl-3-phenyl-7-(p-tolyl)pyrazolo[4,3-e] [1,2,4]triazine (3a).

  DOI：

  10.3987/com-00-8972
• 作为产物：
  描述：

  4-甲氧基苯肼盐酸盐 、 5-乙酰基-3-苯基-1,2,4-三嗪 在 盐酸 作用下， 以 乙醇 为溶剂， 反应 0.08h， 以77%的产率得到1-(3-Phenyl-1,2,4-triazin-5-yl)ethanone (4-methoxyphenyl)hydrazone
  参考文献：
  名称：

  5-Acyl-1,2,4-三嗪苯腙酸促进闭环合成吡唑并[4,3-e][1,2,4]三嗪

  摘要：

  The reaction of various substituted phenylhydrazones of 5-acyl-1,2,4-triazines in the presence of 1.1 equivalent of HCl in boiling ethanol-dioxane mixture has been studied. In all reactions the formation of the corresponding pyrazolo[4,3-e][1,2,4]triazines (3a-r) takes place in good yield. The structures of 3a-r were unequivocally established by spectroscopic methods as well as by X-Ray analysis of selected 5-methyl-3-phenyl-7-(p-tolyl)pyrazolo[4,3-e] [1,2,4]triazine (3a).

  DOI：

  10.3987/com-00-8972

文献信息

• A New Synthesis of Pyrazolo- [4,3-e][1,2,4]triazines via Acid Promoted Ring Closure of the Phenylhydrazones of 5-Acyl-1,2,4-triazines
  作者：Andrzej Rykowski、Mariusz Mojzych、Zbigniew Karczmarzyk

  DOI：10.3987/com-00-8972

  日期：——

  The reaction of various substituted phenylhydrazones of 5-acyl-1,2,4-triazines in the presence of 1.1 equivalent of HCl in boiling ethanol-dioxane mixture has been studied. In all reactions the formation of the corresponding pyrazolo[4,3-e][1,2,4]triazines (3a-r) takes place in good yield. The structures of 3a-r were unequivocally established by spectroscopic methods as well as by X-Ray analysis of selected 5-methyl-3-phenyl-7-(p-tolyl)pyrazolo[4,3-e] [1,2,4]triazine (3a).