1-nitroso-3,5-bis(trifluoromethyl)benzene | 955033-94-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-nitroso-3,5-bis(trifluoromethyl)benzene
• 英文别名: 3,5-bis(trifluoromethyl)nitrosobenzene
• CAS: 955033-94-0
• 化学式: C₈H₃F₆NO
• 分子量: 243.108
• InChiKey: VQJNFPCWBNPYNU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  29.4
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  1-nitroso-3,5-bis(trifluoromethyl)benzene 、 4′-氨基乙酰苯胺 在 溶剂黄146 作用下， 反应 48.0h， 以69%的产率得到(E)-N-(4-((3,5-bis(trifluoromethyl)phenyl)diazenyl)phenyl)acetamide
  参考文献：
  名称：

  Rhodium(III)-Catalyzed Indazole Synthesis by C–H Bond Functionalization and Cyclative Capture

  摘要：

  An efficient, one-step, and highly functional group-compatible synthesis of substituted N-aryl-2H-indazoles is reported via the rhodium(III)-catalyzed C-H bond addition of azobenzenes to aldehydes. The regioselective coupling of unsymmetrical azobenzenes was further demonstrated and led to the development of a new removable aryl group that allows for the preparation of indazoles without N-substitution. The 2-aryl-2H-indazole products also represent a new class of readily prepared fluorophores for which initial spectroscopic characterization has been performed.

  DOI：

  10.1021/ja402761p
• 作为产物：
  描述：

  间二(三氟甲基)苯胺 在 oxone||potassium monopersulfate triple salt 作用下， 以 二氯甲烷 为溶剂， 反应 22.0h， 生成 1-nitroso-3,5-bis(trifluoromethyl)benzene
  参考文献：
  名称：

  一种乏氧荧光探针及其应用

  摘要：

  本发明公开了一种乏氧荧光探针，具有荧光团和乏氧识别基团，所述乏氧识别基团为1‑5个吸电子基团取代的苯基偶氮，所述吸电子基团选自三氟甲基、氟基、硝基、氰基、磺酸基、磺酸酯基、羧基、脂基、酰氨基、烷酰基中的一种或几种。本发明所述的乏氧荧光探针能有效靶向线粒体，可用于细胞器乏氧循环检测，特别是用于细胞/组织/活体乏氧成像、生物标记或传感领域。

  公开号：

  CN112745303B

文献信息

• Reversible Heterochiral Aggregation/Dissociation of Bis(2-hydroxyphenyl)diamides Driven by UV/Vis Irradiation
  作者：Akihiro Nojiri、Naoya Kumagai、Masakatsu Shibasaki

  DOI：10.1002/anie.201106832

  日期：2012.2.27

  Light to dissolve: (R)‐ and (S)‐diamides bearing a hydrogen‐bonding framework (red in picture) and a trans‐azobenzene unit (blue) form an insoluble heterochiral aggregate, which can be dissolved by photoisomerization of the azobenzene unit to the cis conformation by UV irradiation (365 nm). The insoluble aggregate was formed again by subsequent irradiation with visible light (>422 nm). The precipitation

  溶解光：带有氢键骨架的（R）和（S）-二酰胺（图中红色）和反式-偶氮苯单元（蓝色）形成不溶性杂手性聚集体，可通过偶氮苯单元的光异构化使其溶解通过紫外线（365 nm）形成顺式构象。通过随后用可见光（> 422 nm）照射再次形成不溶性聚集体。沉淀和溶解明显是可逆的。
• Piperazines as P2X7 antagonists
  申请人：Betschmann Patrick

  公开号：US20080076924A1

  公开（公告）日：2008-03-27

  Novel compounds of Formula (I) or pharmaceutically acceptable salts thereof, metabolites thereof, isomers thereof, enantiomers thereof or prodrugs thereof of Formula (I) wherein the substituents are as defined herein, which are useful as therapeutic agents.

  化合物I式的新型化合物或其药学上可接受的盐、代谢物、异构体、对映体或前药，其中取代基如本文所定义，这些化合物可用作治疗剂。
• Benzenesulfonamide Compounds and Their Use as Blockers of Calcium Channels
  申请人：Chen Zhengming

  公开号：US20100022595A1

  公开（公告）日：2010-01-28

  The invention relates to piperidinyl and hexahydroazepinyl compounds of Formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R 1 -R 3 , Z and q are defined as set forth in the specification. The invention is also directed to the use compounds of Formula (I) to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.

  本发明涉及公式（I）的哌啶基和六氢唑啉基化合物及其药学上可接受的盐，前药或溶剂，其中R1-R3，Z和q如规范中所述。本发明还针对使用公式（I）的化合物治疗、预防或改善对钙通道阻滞有响应的疾病，特别是N型钙通道。本发明的化合物特别适用于治疗疼痛。
• AUTOTAXIN INHIBITORS
  申请人：SCHULTZ Melanie

  公开号：US20130023556A1

  公开（公告）日：2013-01-24

  The present invention relates to compounds according to formula (I) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers.

  本发明涉及公式(I)的化合物，作为自体税脂酰酰肽酶抑制剂，并且使用这些化合物治疗和/或预防生理和/或病理生理条件，这些条件是由增加的溶血磷脂酸水平和/或自体税脂酰酰肽酶的活化引起、介导和/或传播的，特别是不同的癌症。
• UNDERLAYER COATING COMPOSITION AND PROCESS FOR MANUFACTIURING A MICROELECTRONIC DEVICE
  申请人：Merck Patent GmbH

  公开号：EP2673675B1

  公开（公告）日：2020-07-15