4-(4-hydroxyphenyl)pentanoic acid | 113194-60-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 4-(4-hydroxyphenyl)pentanoic acid
• CAS: 113194-60-8
• 化学式: C₁₁H₁₄O₃
• 分子量: 194.23
• InChiKey: RDDQNMZZZNUDSF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-(4-hydroxyphenyl)pentanoic acid 在 copper dichloride 作用下， 以 四氢呋喃 、 乙醚 、 氯仿 为溶剂， 反应 0.41h， 生成 (7R*,8S*,11R*)-8-hydroxy-7,8,11-trimethylspiro<5.5>undeca-1,4-diene-3-one
  参考文献：
  名称：

  Iwata, Chuzo; Akiyama, Tomohiro; Miyashita, Kazuyuki, Chemical and pharmaceutical bulletin, 1988, vol. 36, # 8, p. 2872 - 2877

  摘要：

  DOI：
• 作为产物：
  描述：

  methyl 4-(4-methoxyphenyl)pentanoate 在 氢碘酸 作用下， 以 溶剂黄146 为溶剂， 反应 7.0h， 以23.5 g的产率得到4-(4-hydroxyphenyl)pentanoic acid
  参考文献：
  名称：

  Iwata, Chuzo; Akiyama, Tomohiro; Miyashita, Kazuyuki, Chemical and pharmaceutical bulletin, 1988, vol. 36, # 8, p. 2872 - 2877

  摘要：

  DOI：

文献信息

• Modified Single-Stranded Polynucleotide
  申请人：Koizumi Makoto

  公开号：US20130253038A1

  公开（公告）日：2013-09-26

  It is intended to provide a polynucleotide that is resistant to RNase and has an RNA interference effect, etc. The present invention provides a single-stranded polynucleotide that is derived from a double-stranded polynucleotide comprising a sense strand polynucleotide corresponding to a target gene, and an antisense strand polynucleotide having a nucleotide sequence complementary to the sense strand polynucleotide, and has a structure in which the 5′-end of the antisense strand and the 3′-end of the sense strand are linked via a phenyl group-containing linker to form a phosphodiester structure at each of these ends.

  本发明旨在提供一种对RNase具有抗性并具有RNA干扰效应的多核苷酸。本发明提供了一种单链多核苷酸，其源自于包含与目标基因相对应的正义链多核苷酸和具有与正义链多核苷酸互补的核苷酸序列的反义链多核苷酸的双链多核苷酸，且具有一种结构，其中反义链的5'-末端和正义链的3'-末端通过含苯基的连接剂连接形成磷酸二酯结构。
• Substituted 4,10-dihydro-10-oxothieno benzoxepins, a method of preparing the same and intermediate thereof and their use as medicaments
  申请人：HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED

  公开号：EP0118867A2

  公开（公告）日：1984-09-19

  There are described substituted 4,10-dihydro-10-oxothienobenzoxepins of the formula wherein R is hydrogen, loweralkyl, or -CH2CH(OH)CH2OH; R1 is hydrogen or loweralkyl; and R2 is hydrogen or loweralkyl, which are useful as anti-inflammatory and analgetic agents, intermediate compounds therefor, and a method of preparing the same.

  描述了式中 R 为氢、低级烷基或-CH2CH(OH)CH2OH；R1 为氢或低级烷基；R2 为氢或低级烷基的取代的 4,10-二氢-10-氧代噻吩并氧杂环庚烷，它们可用作消炎和镇痛剂、其中间化合物以及制备方法。
• MODIFIED SINGLE-STRAND POLYNUCLEOTIDE
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP2647713A1

  公开（公告）日：2013-10-09

  It is intended to provide a polynucleotide that is resistant to RNase and has an RNA interference effect, etc. The present invention provides a single-stranded polynucleotide that is derived from a double-stranded polynucleotide comprising a sense strand polynucleotide corresponding to a target gene, and an antisense strand polynucleotide having a nucleotide sequence complementary to the sense strand polynucleotide, and has a structure in which the 5'-end of the antisense strand and the 3'-end of the sense strand are linked via a phenyl group-containing linker to form a phosphodiester structure at each of these ends.

  本发明旨在提供一种能抗 RNase 并具有 RNA 干扰作用的多核苷酸等。本发明提供了一种由双链多核苷酸衍生的单链多核苷酸，双链多核苷酸包括与靶基因相对应的有义链多核苷酸和具有与有义链多核苷酸互补的核苷酸序列的反义链多核苷酸、其结构是反义链的 5'-端和有义链的 3'-端通过含苯基的连接体连接，在这两端分别形成磷酸二酯结构。
• COATING COMPOSITION, AND COATED METAL PLATE, METAL CONTAINER AND METAL LID FORMED BY COATING WITH SAID COATING COMPOSITION
  申请人：Toyo Seikan Group Holdings, Ltd.

  公开号：EP2857465A1

  公开（公告）日：2015-04-08

  The present invention relates to a polyester coating composition used for forming a coating film of a coated metal plate, a metal container, a metal closure, etc. The coating composition has a crosslinking agent and a curing catalyst incorporated into a mixed polyester resin comprising a mixture of a polyester resin (A) having an acid value of 2 to 50 mg KOH/g and a glass transition temperature (Tg) of 35 to 100°C and a polyester resin (B) having an acid value of 0 to 50 mg KOH/g and a glass transition temperature (Tg) of -20 to 25°C. Thus, a coating composition excellent in resistance to embrittlement over time, corrosion resistance, scrape resistance, retort resistance, and blocking resistance can be provided.

  本发明涉及一种聚酯涂层组合物，用于形成涂层金属板、金属容器、金属封盖等的涂膜。该涂料组合物在混合聚酯树脂中加入了交联剂和固化催化剂，混合聚酯树脂包括酸值为 2 至 50 毫克 KOH/g、玻璃化转变温度（Tg）为 35 至 100°C 的聚酯树脂（A）和酸值为 0 至 50 毫克 KOH/g、玻璃化转变温度（Tg）为 -20 至 25°C 的聚酯树脂（B）的混合物。这样，就能提供一种在抗长期脆化、抗腐蚀、抗刮擦、抗蒸煮和抗阻塞性方面性能优异的涂层组合物。
• IWATA, CHUZO;AKIYAMA, TOMOHIRO;MIYASHITA, KAZUYUKI, CHEM. AND PHARM. BULL., 36,(1988) N 8, C. 2872-2877
  作者：IWATA, CHUZO、AKIYAMA, TOMOHIRO、MIYASHITA, KAZUYUKI

  DOI：——

  日期：——