(5-甲酰基-2-甲氧基苯氧基)乙酸 | 19728-22-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: (5-甲酰基-2-甲氧基苯氧基)乙酸
• 英文名称: (5-FORMYL-2-METHOXYPHENOXY)ACETIC ACID
• 英文别名: 2-(5-formyl-2-methoxyphenoxy)acetic acid
• CAS: 19728-22-4
• 化学式: C₁₀H₁₀O₅
• mdl: MFCD04336654
• 分子量: 210.186
• InChiKey: GCUIYKXCCXKSRU-UHFFFAOYSA-N

物化性质

• 熔点：
  123- 126° C
• 沸点：
  396.1±27.0 °C(Predicted)
• 密度：
  1.311±0.06 g/cm3(Predicted)
• 溶解度：
  氯仿（轻微溶解，超声处理）、DMSO（轻微溶解）、甲醇（轻微溶解，超声处理）

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• 海关编码：
  2918990090

反应信息

• 作为反应物：
  描述：

  (5-甲酰基-2-甲氧基苯氧基)乙酸 、 N-[4-hydroxy-3-(2-oxoacetyl)phenyl]acetamide 在 ammonium acetate 、 溶剂黄146 作用下， 反应 5.0h， 生成 2-(5-(4-(5-acetamido-2-hydroxyphenyl)-1H-imidazol-2-yl)-2-methoxyphenoxy)acetic acid
  参考文献：
  名称：

  Husain, Asif; Siddiqui, Nadeem; Sarafroz, Acta poloniae pharmaceutica, 2011, vol. 68, # 5, p. 657 - 663

  摘要：

  DOI：
• 作为产物：
  描述：

  异香兰素 、 氯乙酸 生成 (5-甲酰基-2-甲氧基苯氧基)乙酸
  参考文献：
  名称：

  Heterocyclic analogs of prostaglandines: IV. Synthesis of 3,7-interphenylene 3,10(11)-dioxa-13-azaprostanoids and 9-oxa-7-azaprostanoids based on tetronic acid and aromatic aldehydes

  摘要：

  An approach was developed to the synthesis of stable in metabolism 3,7-interphenylene 3,10-dioxa-13-aza-and 3,11-dioxa-13-azaprostanoids, and also 9-oxa-7-azaprostanoids with interphenylene and terminal phenyl fragments in the omega-chain based on 3-(alkoxybenzylidene)-and 3-(3-phenylallylidene)tetrahydrofuran-2,4-diones obtained by Knoevenagel condensation of tetronic acid with alkoxy-substituted aromatic aldehydes and cinnamic aldehyde.

  DOI：

  10.1134/s1070428008050047

文献信息

• Isoxazolines and their use as inhibitors of phosphodiesterase type-IV
  申请人：Ranbaxy Laboratories Limited

  公开号：EP1840123A1

  公开（公告）日：2007-10-03

  The present invention relates to isoxazoline derivatives of formula I, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. In particular, compounds disclosed herein can be useful in the treatment of AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases in a patient, particularly in humans. The present invention also relates to processes for the preparation of disclosed compounds, as well as pharmaceutical compositions thereof, and their use as phosphodiesterase (PDE) type IV inhibitors.

  本发明涉及公式I的异噁唑啉衍生物，可用作选择性磷酸二酯酶（PDE）IV型抑制剂。特别是，本文披露的化合物可用于治疗艾滋病、哮喘、关节炎、支气管炎、慢性阻塞性肺病（COPD）、牛皮癣、过敏性鼻炎、休克、特应性皮炎、克罗恩病、成人呼吸窘迫综合征（ARDS）、嗜酸性肉芽肿、过敏性结膜炎、骨关节炎、溃疡性结肠炎和其他炎症性疾病的治疗，尤其是在人类患者中。本发明还涉及所述化合物的制备方法，以及其药物组合物和作为磷酸二酯酶（PDE）IV型抑制剂的用途。
• MIDZUTA, MURATA IURATA MAKOTO;NARUTO, SYUNSUKEH;FUDZIYA, TAKEHKADZU;KADOG+
  作者：MIDZUTA, MURATA IURATA MAKOTO、NARUTO, SYUNSUKEH、FUDZIYA, TAKEHKADZU、KADOG+

  DOI：——

  日期：——
• Heterocyclic analogs of prostaglandines: IV. Synthesis of 3,7-interphenylene 3,10(11)-dioxa-13-azaprostanoids and 9-oxa-7-azaprostanoids based on tetronic acid and aromatic aldehydes
  作者：F. S. Pashkovskii、E. M. Shchukina、M. G. Gribovskii、F. A. Lakhvich

  DOI：10.1134/s1070428008050047

  日期：2008.5

  An approach was developed to the synthesis of stable in metabolism 3,7-interphenylene 3,10-dioxa-13-aza-and 3,11-dioxa-13-azaprostanoids, and also 9-oxa-7-azaprostanoids with interphenylene and terminal phenyl fragments in the omega-chain based on 3-(alkoxybenzylidene)-and 3-(3-phenylallylidene)tetrahydrofuran-2,4-diones obtained by Knoevenagel condensation of tetronic acid with alkoxy-substituted aromatic aldehydes and cinnamic aldehyde.
• Husain, Asif; Siddiqui, Nadeem; Sarafroz, Acta poloniae pharmaceutica, 2011, vol. 68, # 5, p. 657 - 663
  作者：Husain, Asif、Siddiqui, Nadeem、Sarafroz、Khatoon, Yasmin、Rasid, Mohd、Ahmad, Niyaz

  DOI：——

  日期：——