Ethyl 2-(2-(2-(2-acetamidothiazol-4-yl)acetamido)thiazol-4-yl)acetate | 328563-72-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Ethyl 2-(2-(2-(2-acetamidothiazol-4-yl)acetamido)thiazol-4-yl)acetate
• 英文别名: ethyl 2-[2-[[2-(2-acetamido-1,3-thiazol-4-yl)acetyl]amino]-1,3-thiazol-4-yl]acetate
• CAS: 328563-72-0
• 化学式: C₁₄H₁₆N₄O₄S₂
• 分子量: 368.437
• InChiKey: SFJJROPBJBJNOK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  167
• 氢给体数：
  2
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  Ethyl 2-(2-(2-(2-acetamidothiazol-4-yl)acetamido)thiazol-4-yl)acetate 在 sodium hydroxide 、 N,N'-二环己基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 7.5h， 生成 {2-[2-(2-Acetylamino-thiazol-4-yl)-acetylamino]-thiazol-4-yl}-acetic acid 2,5-dioxo-pyrrolidin-1-yl ester
  参考文献：
  名称：

  Synthesis of a novel thiazole based dipeptide chemosensor for Cu(II) in water

  摘要：

  A thiazole-based novel dipeptide module has been synthesized, which exhibited selective Cu(II) recognition in water in the presence of other competing divalent transition metal ions at micromolar concentrations. This is the first example of an entirely synthetic peptide based chemosensor for Cu(II). (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)01853-0
• 作为产物：
  描述：

  2-氨基-4-噻唑乙酸乙酯 在 sodium hydroxide 、 1-羟基苯并三唑 、 N,N'-二环己基碳二亚胺 作用下， 以 溶剂黄146 、 N,N-二甲基甲酰胺 为溶剂， 反应 14.5h， 生成 Ethyl 2-(2-(2-(2-acetamidothiazol-4-yl)acetamido)thiazol-4-yl)acetate
  参考文献：
  名称：

  Synthesis of a novel thiazole based dipeptide chemosensor for Cu(II) in water

  摘要：

  A thiazole-based novel dipeptide module has been synthesized, which exhibited selective Cu(II) recognition in water in the presence of other competing divalent transition metal ions at micromolar concentrations. This is the first example of an entirely synthetic peptide based chemosensor for Cu(II). (C) 2000 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(00)01853-0

文献信息

• Synthesis of a novel thiazole based dipeptide chemosensor for Cu(II) in water
  作者：Santanu Bhattacharya、Mini Thomas

  DOI：10.1016/s0040-4039(00)01853-0

  日期：2000.12

  A thiazole-based novel dipeptide module has been synthesized, which exhibited selective Cu(II) recognition in water in the presence of other competing divalent transition metal ions at micromolar concentrations. This is the first example of an entirely synthetic peptide based chemosensor for Cu(II). (C) 2000 Elsevier Science Ltd. All rights reserved.