2-methoxy-11-oxo-11H-pyrido<2,1-b>quinazoline-8-carboxamide | 65823-02-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: 2-methoxy-11-oxo-11H-pyrido<2,1-b>quinazoline-8-carboxamide
• 英文别名: 2-methoxy-11-oxo-11H-pyrido[2,1-b]quinazoline-8-carboxylic acid amide；2-methoxy-11-oxo-11H-pyrido[2,1-b]quinazoline-8-carboxamide；2-methoxy-11-oxopyrido[2,1-b]quinazoline-8-carboxamide
• CAS: 65823-02-1
• 化学式: C₁₄H₁₁N₃O₃
• 分子量: 269.26
• InChiKey: CLMQEWWJBBAIHC-UHFFFAOYSA-N

物化性质

• 沸点：
  529.3±60.0 °C(Predicted)
• 密度：
  1.45±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  85
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-methoxy-11-oxo-11H-pyrido<2,1-b>quinazoline-8-carboxamide 在 吡啶 、 对甲苯磺酰氯 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 42.0h， 以56.2%的产率得到2-methoxy-11-oxo-11H-pyrido[2,1-b]quinazoline-8-carbonitrile
  参考文献：
  名称：

  Alkaline phosphatase inhibition by a series of pyrido[2,1-b]quinazolines: a possible relationship with cromolyn-like antiallergy activity

  摘要：

  Several known antiallergic agents, including cromolyn sodium and a series of pyrido[2,1-b]quinazolines, inhibit human alkaline phosphatase (ALP), a membranal enzyme associated with calcium uptake in certain tissues. A comparison of ALP and rat passive cutaneous anaphylaxis (PCA) inhibition indicates that PCA inhibition may be associated with drug-ALP interaction, since ALP inhibition potency parallels PCA inhibitory activity. The unpredictability of the PCA test toward clinical efficacy could in part be related to the uncompetitive nature of these inhibitors. The results also suggest that alkaline phosphatase may be a component of membranal calcium channels.

  DOI：

  10.1021/jm00348a025
• 作为产物：
  描述：

  4-氯吡啶-3-羧胺 、 2-氨基-5-甲氧基苯甲酸 在 盐酸 作用下， 以 乙醇 为溶剂， 反应 24.0h， 以16.7%的产率得到2-methoxy-11-oxo-11H-pyrido<2,1-b>quinazoline-8-carboxamide
  参考文献：
  名称：

  Alkaline phosphatase inhibition by a series of pyrido[2,1-b]quinazolines: a possible relationship with cromolyn-like antiallergy activity

  摘要：

  Several known antiallergic agents, including cromolyn sodium and a series of pyrido[2,1-b]quinazolines, inhibit human alkaline phosphatase (ALP), a membranal enzyme associated with calcium uptake in certain tissues. A comparison of ALP and rat passive cutaneous anaphylaxis (PCA) inhibition indicates that PCA inhibition may be associated with drug-ALP interaction, since ALP inhibition potency parallels PCA inhibitory activity. The unpredictability of the PCA test toward clinical efficacy could in part be related to the uncompetitive nature of these inhibitors. The results also suggest that alkaline phosphatase may be a component of membranal calcium channels.

  DOI：

  10.1021/jm00348a025

文献信息

• ——
  作者：

  DOI：——

  日期：——
• SCHWENDER, C. F.;SUNDAY, B. R.;DECKER, V. L., J. MED. CHEM., 1982, 25, N 6, 742-745
  作者：SCHWENDER, C. F.、SUNDAY, B. R.、DECKER, V. L.

  DOI：——

  日期：——
• US4348396A
  申请人：——

  公开号：US4348396A

  公开（公告）日：1982-09-07
• Alkaline phosphatase inhibition by a series of pyrido[2,1-b]quinazolines: a possible relationship with cromolyn-like antiallergy activity
  作者：Charles F. Schwender、Brooks R. Sunday、Victoria L. Decker

  DOI：10.1021/jm00348a025

  日期：1982.6

  Several known antiallergic agents, including cromolyn sodium and a series of pyrido[2,1-b]quinazolines, inhibit human alkaline phosphatase (ALP), a membranal enzyme associated with calcium uptake in certain tissues. A comparison of ALP and rat passive cutaneous anaphylaxis (PCA) inhibition indicates that PCA inhibition may be associated with drug-ALP interaction, since ALP inhibition potency parallels PCA inhibitory activity. The unpredictability of the PCA test toward clinical efficacy could in part be related to the uncompetitive nature of these inhibitors. The results also suggest that alkaline phosphatase may be a component of membranal calcium channels.