2-(thiophen-2-yl)but-3-en-2-ol | 121283-46-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 杂芳族化合物
• 英文名称: 2-(thiophen-2-yl)but-3-en-2-ol
• 英文别名: 2-[2]thienyl-but-3-en-2-ol；2-Thiophen-2-ylbut-3-en-2-ol
• CAS: 121283-46-3
• 化学式: C₈H₁₀OS
• 分子量: 154.233
• InChiKey: DQMOUGMYQKXNNF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  48.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(thiophen-2-yl)but-3-en-2-ol 在 重铬酸吡啶 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以70%的产率得到3-(2-thienyl)-2-butenal
  参考文献：
  名称：

  Conformational Biasing in 1,3-Oxidative Rearrangements of Dienols

  摘要：

  1-Vinyl-2-cycloalkenols are oxidized to form conjugated dienones in useful yields. Although this oxidative rearrangement is general, severe steric interactions can favor the formation of a conjugated dienal instead of a conjugated dienone. Several heterocyclic analogues were also studied.

  DOI：

  10.3987/com-07-s(w)62
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氨 、 sodium 作用下， 生成 2-(thiophen-2-yl)but-3-en-2-ol
  参考文献：
  名称：

  The Preparation and Properties of Some Thienyl Butenols^1a

  摘要：

  DOI：

  10.1021/ja01166a070

文献信息

• Visible-Light Photocatalytic Difluoroalkylation-Induced 1, 2-Heteroarene Migration of Allylic Alcohols in Batch and Flow
  作者：Xiao-Jing Wei、Timothy Noël

  DOI：10.1021/acs.joc.8b01624

  日期：2018.9.21

  A convenient method for the preparation of sp(3)-rich heterocycles is reported. The method comprises a photocatalytic difluoroalkylation-induced 1,2-heteroarene migration of allylic alcohols. Here we describe for the first time the benefits of using flow to facilitate such migration reactions, including shorter reaction times, higher selectivities, and opportunities to scale the chemistry.
• CERTAIN PLADIENOLIDE COMPOUNDS AND METHODS OF USE
  申请人：EISAI R&D MANAGEMENT CO., LTD.

  公开号：US20210163456A1

  公开（公告）日：2021-06-03

  The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.
• [EN] CERTAIN PLADIENOLIDE COMPOUNDS AND METHODS OF USE<br/>[FR] CERTAINS COMPOSÉS DE PLADIÉNOLIDE ET PROCÉDÉS D'UTILISATION
  申请人：KEANEY GREGG F

  公开号：WO2019199667A2

  公开（公告）日：2019-10-17

  The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.