1-(2-amino-4,5-dimethoxyphenyl)-2-phenyl-1-ethanone | 85636-82-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: 1-(2-amino-4,5-dimethoxyphenyl)-2-phenyl-1-ethanone
• 英文别名: 2-amino-4,5-dimethoxyphenyl benzyl ketone；1-(2-Amino-4,5-dimethoxyphenyl)-2-phenylethanone
• CAS: 85636-82-4
• 化学式: C₁₆H₁₇NO₃
• 分子量: 271.316
• InChiKey: DWUNCGBRFGCLSO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  61.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(2-amino-4,5-dimethoxyphenyl)-2-phenyl-1-ethanone 在 吡啶 、 盐酸 、 sodium tetrahydroborate 、 对甲苯磺酸 、 溶剂黄146 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 1.0h， 生成 4-[3-benzyl-5,6-dimethoxy-1-(4-methylphenylsulfonyl)-1H-2-indolyl]-2-butanone
  参考文献：
  名称：

  Simple route to 3-(2-indolyl)-1-propanones via a furan recyclization reaction

  摘要：

  A simple route to 1-R-3-(2-indolyl)-1-propanones has been elaborated based on recyclization of 2-(2-aminobenzyl)furan derivatives. Being a modification of the Reissert indole synthesis, our approach employs the furan ring as a source of carbonyl function. This approach is general and allows varying of substituents in aromatic ring as well as in 3-position of indole nucleus. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.10.056
• 作为产物：
  描述：

  1-(4,5-dimethoxy-2-nitrophenyl)-2-phenyl-1-ethanone 在 铁粉 、 溶剂黄146 作用下， 以 水 、 乙酸乙酯 为溶剂， 反应 6.0h， 以66%的产率得到1-(2-amino-4,5-dimethoxyphenyl)-2-phenyl-1-ethanone
  参考文献：
  名称：

  Simple route to 3-(2-indolyl)-1-propanones via a furan recyclization reaction

  摘要：

  A simple route to 1-R-3-(2-indolyl)-1-propanones has been elaborated based on recyclization of 2-(2-aminobenzyl)furan derivatives. Being a modification of the Reissert indole synthesis, our approach employs the furan ring as a source of carbonyl function. This approach is general and allows varying of substituents in aromatic ring as well as in 3-position of indole nucleus. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2006.10.056

文献信息

• Kamath, H. V.; Dhekne, Vijay V.; Kulkarni, Sheshgiri N., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1982, vol. 21, # 10, p. 911 - 913
  作者：Kamath, H. V.、Dhekne, Vijay V.、Kulkarni, Sheshgiri N.

  DOI：——

  日期：——
• Byford, A.; Goadby, P.; Hooper, M., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1988, vol. 27, # 1-12, p. 396 - 397
  作者：Byford, A.、Goadby, P.、Hooper, M.、Kamath, H. V.、Kulkarni, Sheshgiri N.

  DOI：——

  日期：——
• KAMATH, H. V.;DHEKNE, VIJAY, V.;KULKARNI, SHESHGIRI, N., INDIAN J. CHEM., 1982, 21, N 10, 911-913
  作者：KAMATH, H. V.、DHEKNE, VIJAY, V.、KULKARNI, SHESHGIRI, N.

  DOI：——

  日期：——
• BYFORD, A.;GOADBY, P.;HOOPER, M.;KAMATH, H. V.;KULKARNI, SHESHGIRI, INDIAN J. CHEM. B, 27,(1988) N 4, C. 396-397
  作者：BYFORD, A.、GOADBY, P.、HOOPER, M.、KAMATH, H. V.、KULKARNI, SHESHGIRI

  DOI：——

  日期：——
• Simple route to 3-(2-indolyl)-1-propanones via a furan recyclization reaction
  作者：Alexander V. Butin、Sergey K. Smirnov、Tatyana A. Stroganova、Wolfgang Bender、Gennady D. Krapivin

  DOI：10.1016/j.tet.2006.10.056

  日期：2007.1

  A simple route to 1-R-3-(2-indolyl)-1-propanones has been elaborated based on recyclization of 2-(2-aminobenzyl)furan derivatives. Being a modification of the Reissert indole synthesis, our approach employs the furan ring as a source of carbonyl function. This approach is general and allows varying of substituents in aromatic ring as well as in 3-position of indole nucleus. (c) 2006 Elsevier Ltd. All rights reserved.