2,4-dibromo-1,5-diphenylpentan-2-one | 275793-63-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4-dibromo-1,5-diphenylpentan-2-one
• 英文别名: 2,4-dibromo-1,5-diphenyl-pentan-3-one；2,4-Dibrom-1,5-diphenyl-pentan-3-on；2,4-Dibromo-1,5-diphenylpentan-3-one；2,4-dibromo-1,5-diphenylpentan-3-one
• CAS: 275793-63-0
• 化学式: C₁₇H₁₆Br₂O
• 分子量: 396.121
• InChiKey: QFWZETIXUONIIE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-吡咯甲酸叔丁酯 、 2,4-dibromo-1,5-diphenylpentan-2-one 在 diethylzinc 作用下， 以 正己烷 、 甲苯 为溶剂， 反应 6.0h， 以84%的产率得到tert-butyl 2α,4α-dibenzyl-3-oxo-8-azabicyclo[3.2.1]oct-6-ene-8-carboxylate
  参考文献：
  名称：

  Synthesis and Functionalization of New Tropanes Designed for Use as Scaffolds in Combinatorial Chemistry

  摘要：

  DOI：

  10.1002/1099-0690(200012)2000:23<3909::aid-ejoc3909>3.0.co;2-r
• 作为产物：
  描述：

  联甲基苯乙烯酮 在 乙醚 、 溴 、 镍 作用下， 生成 2,4-dibromo-1,5-diphenylpentan-2-one
  参考文献：
  名称：

  ANTIMALARIALS. α,β-DIMORPHOLINYL KETONES AND RELATED COMPOUNDS^{1, 2}

  摘要：

  DOI：

  10.1021/jo01158a007

文献信息

• METHOD FOR PRODUCING CYCLIC CARBONATE
  申请人：NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY

  公开号：US20160145234A1

  公开（公告）日：2016-05-26

  Provided is a method for producing a cyclic carbonate obtained by reacting epoxide and carbon dioxide, the method being capable of efficiently producing a cyclic carbonate at a high conversion rate and a high yield, in which degradation of the catalyst over time is suppressed and catalytic activity hardly decreases. A method for producing a cyclic carbonate by reacting epoxide and carbon dioxide in the presence of a quaternary onium salt selected from the group consisting of a quaternary ammonium salt having a halogenated anion as a counter ion and a quaternary phosphonium salt having a halogenated anion as a counter ion, or in the presence of a solid catalyst obtained by immobilizing the quaternary onium salt onto a carrier, wherein an organohalogen compound containing at least one halogen atom in one molecule is added to the reaction system.

  提供了一种生产环状碳酸酯的方法，该方法通过反应环氧化物和二氧化碳获得，能够高效地以高转化率和高产率生产环状碳酸酯，同时抑制催化剂随时间降解并且催化活性几乎不会下降。在存在从属于具有卤素阴离子作为对离子的季铵盐和具有卤素阴离子作为对离子的季膦盐中选择的季铵盐，或者存在通过将季铵盐固定在载体上而获得的固体催化剂的情况下，通过在反应体系中添加含有至少一个卤素原子的有机卤素化合物来生产环状碳酸酯的方法。
• tert-Butoxycarbamate group: a useful protecting group for the synthesis of orthogonally protected ‘tropane-like’ scaffolds
  作者：Jean-Laurent Paparin、Christophe Crévisy、René Grée

  DOI：10.1016/s0040-4039(00)00198-2

  日期：2000.4

  The first synthesis of N-Boc-protected tropanes by a [4+3] cycloaddition reaction is described. The Boc group has been cleanly removed demonstrating that this group would be very useful for the synthesis of ‘tropane-like’ scaffolds for combinatorial chemistry.

  描述了通过[4 + 3]环加成反应的N -Boc保护的托烷的首次合成。Boc组已被彻底清除，表明该组对于合成用于组合化学的“托烷类”支架非常有用。
• METHOD FOR MANUFACTURING CYCLIC CARBONATE
  申请人：National Institute of Advanced Industrial Science and Technology

  公开号：EP3023418A1

  公开（公告）日：2016-05-25

  Provided is a method for producing a cyclic carbonate obtained by reacting epoxide and carbon dioxide, the method being capable of efficiently producing a cyclic carbonate at a high conversion rate and a high yield, in which degradation of the catalyst over time is suppressed and catalytic activity hardly decreases. A method for producing a cyclic carbonate by reacting epoxide and carbon dioxide in the presence of a quaternary onium salt selected from the group consisting of a quaternary ammonium salt having a halogenated anion as a counter ion and a quaternary phosphonium salt having a halogenated anion as a counter ion, or in the presence of a solid catalyst obtained by immobilizing the quaternary onium salt onto a carrier, wherein an organohalogen compound containing at least one halogen atom in one molecule is added to the reaction system.

  本发明提供了一种通过环氧化物和二氧化碳反应获得环状碳酸盐的生产方法，该方法能够以高转化率和高产率高效生产环状碳酸盐，其中催化剂随时间推移的降解受到抑制，催化活性几乎没有降低。 一种生产环碳酸盐的方法，该方法通过环氧化物和二氧化碳在季鎓盐的存在下或在通过将季鎓盐固定在载体上获得的固体催化剂的存在下反应环碳酸盐，该季鎓盐选自具有卤化阴离子作为反离子的季铵盐和具有卤化阴离子作为反离子的季鏻盐组成的组，其中在一个分子中含有至少一个卤原子的有机卤化合物被添加到反应体系中。
• US9856229B2
  申请人：——

  公开号：US9856229B2

  公开（公告）日：2018-01-02