(+/-)-[4-(α-hydroxy-benzyl)-phenyl]-acetic acid | 78212-11-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (+/-)-[4-(α-hydroxy-benzyl)-phenyl]-acetic acid
• 英文别名: (+/-)-[4-(α-Hydroxy-benzyl)-phenyl]-essigsaeure；[4-(α-Hydroxy-benzyl)-phenyl]-essigsaeure；2-[4-[Hydroxy(phenyl)methyl]phenyl]acetic acid
• CAS: 78212-11-0
• 化学式: C₁₅H₁₄O₃
• 分子量: 242.274
• InChiKey: IDGORZHJAKRWOG-UHFFFAOYSA-N

物化性质

• 熔点：
  108-109 °C(Solv: benzene (71-43-2))
• 沸点：
  449.8±35.0 °C(Predicted)
• 密度：
  1.245±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-(4-苯甲酰基苯基)乙酸 在 sodium tetrahydroborate 作用下， 生成 (+/-)-[4-(α-hydroxy-benzyl)-phenyl]-acetic acid
  参考文献：
  名称：

  Synthesis of d-p-(α-Hydroxybenzyl)-phenylacetic Acid¹

  摘要：

  DOI：

  10.1021/ja01156a001

文献信息

• US20140343227A1
  申请人：——

  公开号：US20140343227A1

  公开（公告）日：2014-11-20
• US8802819B2
  申请人：——

  公开号：US8802819B2

  公开（公告）日：2014-08-12
• [EN] DIKETOPIPERAZINE FORMING DIPEPTIDYL LINKER<br/>[FR] DICÉTOPIPÉRAZINE FORMANT UN PONT DIPEPTIDYLE
  申请人：LONZA AG

  公开号：WO2012055509A1

  公开（公告）日：2012-05-03

  The invention relates to a method for homogeneous solution phase peptide synthesis (HSPPS) of a N-terminal peptide fragment PEP-N and a C-terminal peptide fragment C-PEP, with C- PEP carrying a specific diketopiperazine (DKP) comprising C-terminal protecting group, which contains a handle group HG, with HG being connected to the C-terminus of the peptide fragment; thereby this specific DKP comprising C-terminal protecting group can be selectively cleaved from the peptide as a conventionally used C-terminal protecting group. By the use of this DKP and HG comprising C-terminal protecting group, certain process steps in convergent peptide synthesis based on a combination of HSPPS and solid phase peptide synthesis (SPPS) can be avoided. The invention relates further to a method for the preparation of such specifically protected fragment C-PEP by SPPS by using a linker comprising a specific dipeptide and HG for connecting the growing peptide chain to the resin, which linker forms said DKP group, when the peptide fragment C-PEP is cleaved from the supporting resin; and further to the intermediates of the preparation method.
• Synthesis of d-p-(α-Hydroxybenzyl)-phenylacetic Acid¹
  作者：Robert P. Zelinski、Byron W. Turnquest、Eugene C. Martin

  DOI：10.1021/ja01156a001

  日期：1951.12