N-(anthracene-2-yl)guanidine | 54-72-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 蒽
• 英文名称: N-(anthracene-2-yl)guanidine
• 英文别名: [2]anthryl-guanidine；[2]Anthryl-guanidin；N'-(2-anthracenyl)guanidine；2-Anthrylguanidine；2-anthracen-2-ylguanidine
• CAS: 54-72-8
• 化学式: C₁₅H₁₃N₃
• 分子量: 235.288
• InChiKey: BJAQGDAZQMYUNA-UHFFFAOYSA-N

物化性质

• 沸点：
  445.2±28.0 °C(Predicted)
• 密度：
  1.25±0.1 g/cm3(Predicted)
• 熔点：
  215 °C (decomp)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  64.4
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-氨基蒽 在 盐酸 、 氯仿 作用下， 以 甲醇 、 水 为溶剂， 反应 18.0h， 生成 N-(anthracene-2-yl)guanidine
  参考文献：
  名称：

  The utilization of ball milling in synthesis of aryl guanidines through guanidinylation and N-Boc-deprotection sequence

  摘要：

  Solid state ball milling was used in guanidinylation reactions of aromatic amines with N,N'-Di-Boc-1H-pyrazole-1-carboxamidine reagent. Reaction conditions are advantageous, and in general reactions proceed in significantly shorter reaction times and in higher yields than under the conventional solution conditions. Mechanochemical conditions were also successfully applied to the cleavage of N-Boc protecting group. (C) 2018 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2018.11.038

文献信息

• Royer, Journal of the Chemical Society, 1949, p. 1665
  作者：Royer

  DOI：——

  日期：——
• The utilization of ball milling in synthesis of aryl guanidines through guanidinylation and N-Boc-deprotection sequence
  作者：Mateja Đud、Zoran Glasovac、Davor Margetić

  DOI：10.1016/j.tet.2018.11.038

  日期：2019.1

  Solid state ball milling was used in guanidinylation reactions of aromatic amines with N,N'-Di-Boc-1H-pyrazole-1-carboxamidine reagent. Reaction conditions are advantageous, and in general reactions proceed in significantly shorter reaction times and in higher yields than under the conventional solution conditions. Mechanochemical conditions were also successfully applied to the cleavage of N-Boc protecting group. (C) 2018 Elsevier Ltd. All rights reserved.