7-methyl-2-(pyridin-2-yl)imidazo[1,2-a]pyridine | 364043-73-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并吡啶类
• 英文名称: 7-methyl-2-(pyridin-2-yl)imidazo[1,2-a]pyridine
• 英文别名: 7-Methyl-2-(2-pyridyl)imidazo[1,2-a]pyridine；7-methyl-2-pyridin-2-ylimidazo[1,2-a]pyridine
• CAS: 364043-73-2
• 化学式: C₁₃H₁₁N₃
• 分子量: 209.25
• InChiKey: JCJOZICYUQJISP-UHFFFAOYSA-N

物化性质

• 密度：
  1.19±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  30.2
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  7-methyl-2-(pyridin-2-yl)imidazo[1,2-a]pyridine 在 溶剂黄146 、 sodium nitrite 作用下， 反应 0.5h， 以87%的产率得到Imidazo(1,2-a)pyridine, 7-methyl-3-nitroso-2-(2-pyridinyl)-
  参考文献：
  名称：

  Synthesis of 3-Nitrosoimidazo[1,2-a]pyridine Derivatives as Potential Antiretroviral Agents

  摘要：

  Ten 2-aryl or heteroaryl-3-nitrosoimidazo[1,2-a]pyridine derivatives were synthesised as potential antiretroviral agents. The new compounds were characterized by elemental analysis, (1)H NMR, and by crystallography for (14). The compounds were devoid of any activity against HIV-1 or HIV-2.

  DOI：

  10.1002/1521-4184(200107)334:7<224::aid-ardp224>3.0.co;2-7
• 作为产物：
  描述：

  2-氨基-4-甲基吡啶 、 2-(2-溴乙酰基)吡啶 以 乙醇 为溶剂， 反应 4.0h， 以48%的产率得到7-methyl-2-(pyridin-2-yl)imidazo[1,2-a]pyridine
  参考文献：
  名称：

  Influence of 2-Substituent on the Activity of Imidazo[1,2-a] Pyridine Derivatives Against Human Cytomegalovirus

  摘要：

  The synthesis of various 2-substituted imidazo[1,2-a]pyridine bearing a thioether side chain in position 3 was reported. The new compounds were characterized by H-1 and C-13 NMR spectra. A conformational study was obtained by X-ray crystallographic analysis for 2-biphen-4-ylimidazopyridine 7. The antiviral activity against human cytomegalovirus (HCMV) was investigated. It was strongly influenced by the nature of C-2 substituent. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(01)00347-9

文献信息

• Copper-Catalyzed Synthesis of Imidazo[1,2-<i>a</i>]pyridines through Tandem Imine Formation-Oxidative Cyclization under Ambient Air: One-Step Synthesis of Zolimidine on a Gram-Scale
  作者：Avik Kumar Bagdi、Matiur Rahman、Sougata Santra、Adinath Majee、Alakananda Hajra

  DOI：10.1002/adsc.201300298

  日期：2013.6.17

  A new copper‐catalyzed oxidative cyclization via CH amination between 2‐aminopyridines and methyl aryl/heteroaryl ketones has been developed under ambient air. Imidazo[1,2‐a]pyridines containing a wide range of functional groups have been synthesized from basic and easily available starting materials. This simple, one‐pot reaction protocol is applicable for the direct preparation of zolimidine (a

  一种新的铜催化的氧化环化经由Ç  ħ胺化2-氨基吡啶和间甲基芳基/杂芳基酮已根据环境空气显影。含有多种官能团的咪唑并[1,2- a ]吡啶是从碱性且容易获得的起始原料合成的。这种简单的一锅法反应方案适用于大规模直接制备唑来咪定（市售的抗溃疡药）。