dilaurylphosphate anhydride | 864523-81-9

• 分子结构分类: 有机化合物 - 有机氧化合物 - 有机含氧阴离子化合物
• 英文名称: dilaurylphosphate anhydride
• 英文别名: Didodecoxyphosphoryl didodecyl phosphate
• CAS: 864523-81-9
• 化学式: C₄₈H₁₀₀O₇P₂
• 分子量: 851.265
• InChiKey: ZVRURYSWJGXDGJ-UHFFFAOYSA-N

物化性质

• 熔点：
  51-52 °C
• 沸点：
  754.0±29.0 °C(Predicted)
• 密度：
  0.944±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  21.3
• 重原子数：
  57
• 可旋转键数：
  50
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  80.3
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  二(十二烷基)磷酸酯 在 吡啶 作用下， 反应 3.0h， 以78%的产率得到dilaurylphosphate anhydride
  参考文献：
  名称：

  POLYCATIONIZED PHOSPHOLIPID DERIVATIVES

  摘要：

  本发明提供了新颖的磷脂衍生物。此外，本发明提供了在细胞内具有出色的基因/核酸引入效率的脂质膜结构。

  公开号：

  US20100094020A1

文献信息

• Selective PP and POP Bond Formations through Copper-Catalyzed Aerobic Oxidative Dehydrogenative Couplings of H-Phosphonates
  作者：Yongbo Zhou、Shuangfeng Yin、Yuxing Gao、Yufen Zhao、Midori Goto、Li-Biao Han

  DOI：10.1002/anie.201003484

  日期：2010.9.10

  Different copper complexes selectively catalyze the aerobic oxidative coupling of H‐phosphonates to afford either hypophosphates and pyrophosphates in high yields with high selectivity (see scheme; tmeda=N,N,N′,N′‐tetramethylethylenediamine).

  不同的铜络合物选择性催化H-膦酸酯的需氧氧化偶联，以高收率和高选择性提供次磷酸盐和焦磷酸盐（参见方案; tmeda = N，N，N'，N'-四甲基乙二胺）。
• [EN] MIXED CATALYTIC COMPOSITION<br/>[FR] COMPOSITION CATALYTIQUE MIXTE
  申请人：CROMPTON GMBH

  公开号：WO2004050597A1

  公开（公告）日：2004-06-17

  The present invention relates to catalytic compositions for esterification, transesterification and polycondensation reactions, a process for the catalysis of said reactions employing such catalytic compositions and polyesters or resins obtainable by this process.

  本发明涉及用于酯化、转酯化和聚合反应的催化组合物，以及使用这种催化组合物催化该反应的过程和可由该过程获得的聚酯或树脂。
• Mixed catalyst composition
  申请人：Roder Jens

  公开号：US20060052575A1

  公开（公告）日：2006-03-09

  The present invention relates to catalytic compositions for esterification, transesterification and polycondensation reactions, a process for the catalysis of said reactions employing such catalytic compositions and polyesters or resins obtainable by this process.

  本发明涉及用于酯化、酯交换和缩聚反应的催化组合物、使用此类催化组合物催化上述反应的工艺以及通过该工艺可获得的聚酯或树脂。
• Liposomal Polyamine−Dialkyl Phosphate Conjugates as Effective Gene Carriers: Chemical Structure, Morphology, and Gene Transfer Activity
  作者：Takehisa Dewa、Tomohiro Asai、Yuka Tsunoda、Kiyoshi Kato、Daisuke Baba、Misa Uchida、Ayumi Sumino、Kayoko Niwata、Takuya Umemoto、Kouji Iida、Naoto Oku、Mamoru Nango

  DOI：10.1021/bc900376y

  日期：2010.5.19

  Synthetic cationic lipids are promising transfection agents for gene therapy. We report here that polyamine conjugates of dialkyl phosphates, combined with natural lipids and assembled in the form of liposomes (polycationic liposome: PCL), possess high transfection activity in the COS-1 cell line. Furthermore, we describe the functional morphology of the PCL/DNA complexes as revealed by atomic force microscopy (AFM). The conjugates were synthesized from dialkyl phosphates (with alkyl chain lengths of 12, 14, or 16 carbons) by reaction with the polyamine molecules, spermidine, spermine, or polyethylenimine (PEI(1800)). [Dewa, T., et al. Bioconjugate Chem. 2004, 15, 824]. The PCL composed of the spermidine and C16 conjugate combined with phospholipid and cholesterol (conjugate/phospholipid/cholesterol = 1/1/1 as a molar ratio) exhibited 3.6 times higher activity than that of a popular commercial product. Systematic tests revealed clear correlations of the transgene activity with physical properties of the polyamine, in particular, that longer alkyl chains and the lower molecular weight polyamines (spermidine, spermine) favor high efficacy at the higher nitrogen/phosphate ratio = 24 (N/P, stoichiometric ratio of nitrogen in the conjugate to phosphate in DNA). The low molecular weight polyamine-based PCLs, which formed 150-400 nm particles with plasmid DNA (lipoplexes), exhibited similar to 3-fold higher gene transfer activity than micellar aggregates (lacking phospholipid and cholesterol) of the corresponding conjugate. In contrast, the PEI-based PCL formed large aggregates (similar to 1 mu m), that, like the micellar aggregate form, had low activity. Activity of the low molecular weight polyamine-based PCLs increased linearly with the NIP of the lipoplex up to N/P = 24. Formation of lipoplexes was examined by agarose gel electrophoresis, dynamic light scattering (DLS), and AFM. At the lower N/P = 5, large aggregates of complex ( I urn), in which DNA molecules were loosely packed, were observed. At higher NIP, lipoplexes were converted into smaller particles (150-400 nin) having a lamellar structure, in which DNA molecules were tightly packed. Such morphological features of the lipoplex correlate with the dependence of transfection on the N/P in that the lamellar structures gave superior transfection. AFM also indicated that the lipoplexes disassembled significantly. releasing DNA, when the lipoplexes were exposed to acidic conditions (pH 4). The significance for transfection activity of the metamorphosis of bilayer lipoplexes is discussed relative to that of the less active micellar aggregate form, which is unresponsive to pH change.
• MIXED CATALYTIC COMPOSITION
  申请人：Crompton GmbH

  公开号：EP1567473A1

  公开（公告）日：2005-08-31