5,15-diphenyl-10-p-chlorophenyl-2,3,17,18-tetraethylporphine | 137018-28-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四吡咯及其衍生物
• 英文名称: 5,15-diphenyl-10-p-chlorophenyl-2,3,17,18-tetraethylporphine
• CAS: 137018-28-1
• 化学式: C₄₆H₄₁ClN₄
• 分子量: 685.311
• InChiKey: GDMXYUAZLIVHTP-LLEXUGCUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  13.0
• 重原子数：
  51.0
• 可旋转键数：
  7.0
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  57.36
• 氢给体数：
  2.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  2-benzoyl-3,4-diethylpyrrole 在 盐酸 、 sodium tetrahydroborate 、 zinc diacetate 作用下， 以 四氢呋喃 、 乙醇 、 丙酸 为溶剂， 生成 5,15-diphenyl-10-p-chlorophenyl-2,3,17,18-tetraethylporphine
  参考文献：
  名称：

  Selective syntheses of unsymmetrical meso-arylporphyrins

  摘要：

  A selective synthetic route to unsymmetrical meso-arylporphyrins is described. New hybrid type of unsymmetrical porphyrin with C2-nu symmetry was prepared according to the new method.

  DOI：

  10.1016/0040-4039(91)80031-z

文献信息

• Sickled Erythrocytes with Anti-tumor Agents Induce Tumor Vaso-occlusion and Tumoricidal Effects
  申请人：Terman David S.

  公开号：US20120195869A1

  公开（公告）日：2012-08-02

  The present invention provides erythrocytes or nucleated erythrocyte precursors from animals or patients with at least one S hemoglobin allele which are capable of selectively localizing in tumor vasculature resulting in vaso-occlusion, hemolysis and heme release. A tumoricidal effect is achieved when these cells are administered in before during or after administration of (i) an agent(s) that interferes with degradation of reactive oxygen species, (ii) impairs glucose uptake and/or (iii) chemotherapy. These cells also carry oncolytic viruses, antitumor proteins, multidrug resistant proteins, chemotherapy, monoclonal antibodies, superantigens, superantigen conjugates and fusion proteins, siRNAs, plasmids and non-protein toxins and attenuated tumoricidal bacterial cells specifically into the tumors and induce a tumoricidal effect.
• US8431117B2
  申请人：——

  公开号：US8431117B2

  公开（公告）日：2013-04-30