6-[4-(3-Chloro-phenyl)-piperazin-1-yl]-2H-pyridazin-3-one | 362661-30-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 6-[4-(3-Chloro-phenyl)-piperazin-1-yl]-2H-pyridazin-3-one
• 英文别名: 6-[4-(3-Chlorophenyl)-1-piperazinyl]-3(2H)-pyridazinone；3-[4-(3-chlorophenyl)piperazin-1-yl]-1H-pyridazin-6-one
• CAS: 362661-30-1
• 化学式: C₁₄H₁₅ClN₄O
• 分子量: 290.752
• InChiKey: JRICBBUKRWXBJW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  47.9
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  6-[4-(3-Chloro-phenyl)-piperazin-1-yl]-2H-pyridazin-3-one 在 potassium carbonate 、 一水合肼 作用下， 以 甲醇 、 乙醇 、 丙酮 为溶剂， 反应 9.0h， 生成 6-[4-(3-chlorophenyl)piperazine]-3(2H)-pyridazinone-2-acetyl-2-benzal hydrazone
  参考文献：
  名称：

  Utku, Semra; Goekce, Mehtap; Orhan, Ilkay, Arzneimittel-Forschung/Drug Research, 2011, vol. 61, # 1, p. 1 - 7

  摘要：

  DOI：
• 作为产物：
  描述：

  1-(3-氯苯基)哌嗪 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 6.0h， 生成 6-[4-(3-Chloro-phenyl)-piperazin-1-yl]-2H-pyridazin-3-one
  参考文献：
  名称：

  Utku, Semra; Goekce, Mehtap; Orhan, Ilkay, Arzneimittel-Forschung/Drug Research, 2011, vol. 61, # 1, p. 1 - 7

  摘要：

  DOI：

文献信息

• Synthesis and analgesic and anti-inflammatory activities 6-substituted-3(2H)-pyridazinone-2-acetyl-2-(p-substituted/nonsubstituted benzal)hydrazone derivatives
  作者：Mehtap Gökçe、Semra Utku、Esra Küpeli

  DOI：10.1016/j.ejmech.2009.04.048

  日期：2009.9

  this study new 6-substituted-3(2H)-pyridazinone-2-acetyl-2-(p-substituted benzal)hydrazone V derivatives were synthesized as analgesic and anti-inflammatory agents. The structures of compounds were elucidated by spectral and elemental analysis. Compounds Va, Vb and Vc were exhibited more potent analgesic activity than ASA. Also these derivatives demonstrated anti-inflammatory activity as well as standard

  在该研究中，合成了新的6-取代的3（2 H）-哒嗪酮-2-乙酰基-2-（对位的取代苯并））Ⅴ衍生物作为镇痛药和消炎药。通过光谱和元素分析阐明了化合物的结构。化合物Va，Vb和Vc比ASA具有更强的镇痛作用。这些衍生物以及标准化合物消炎痛也显示出抗炎活性。检查了这些化合物对胃粘膜的副作用。与参考非甾体类抗炎药（NSAIDs）相比，这些化合物均未显示出胃溃疡作用。在现有数据的基础上，还讨论了V衍生物的结构-活性关系。
• Synthesis of antipyrine/pyridazinone hybrids and investigation of their in vivo analgesic and anti-inflammatory activities
  作者：SULTAN BAYTAŞ、NAZAN İNCELER、KHATEREH FATTAHPOUR MAVANEH、MECİT ORHAN ULUDAĞ、NURETTİN ABACIOĞLU、MEHTAP GÖKÇE

  DOI：10.3906/kim-1111-29

  日期：——

  Eleven antipyrine/pyridazinone hybrids were synthesized and evaluated for their in vivo analgesic and anti-inflammatory activities by p-benzoquinone-induced writhing test and carrageenan-induced paw edema model, respectively. The test results indicated that compounds 6a, 6c, and 6d were equally or more potent analgesic and anti-inflammatory agents than aspirin and indomethacin, respectively. Side effects of the compounds were examined on gastric mucosa. Most of the compounds were found to be non-ulcerogenic under test conditions.

  合成了 11 种抗吡啶/哒嗪酮杂交化合物，并分别通过对苯醌诱导的蠕动试验和卡拉胶诱导的爪水肿模型对其体内镇痛和抗炎活性进行了评估。 试验结果表明，与阿司匹林和吲哚美辛相比，化合物 6a、6c 和 6d 分别具有相同或更强的镇痛和抗炎作用。研究还考察了化合物对胃黏膜的副作用。 在测试条件下，发现大多数化合物都不会引起溃疡。
• Synthesis and antinociceptive activity of 6-substituted-3-pyridazinone derivatives
  作者：Mehtap Gokçe、Deniz Dogruer、Mustafa Fethi Sahin

  DOI：10.1016/s0014-827x(01)01037-0

  日期：2001.4

  A series of 3-pyridazinones carrying morpholino, arylpiperidino and arylpiperazino moiety in the position 6 IIa-g were synthesized and evaluated for antinociceptive activity. In the modified Koster test in mice 4-(4-fluorophenyl) piperazine, IIf, was found the most active compound. All the compounds except IId were more active than aspirin in the antinociceptive activity test. (C) 2001 Elsevier Science S.A. All rights reserved.