(R)-1-(3-chloro-2-hydroxypropyl)-pyrrolidin-2-one | 1153630-79-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: (R)-1-(3-chloro-2-hydroxypropyl)-pyrrolidin-2-one
• 英文别名: 1-[(2R)-3-chloro-2-hydroxypropyl]pyrrolidin-2-one
• CAS: 1153630-79-5
• 化学式: C₇H₁₂ClNO₂
• 分子量: 177.631
• InChiKey: KSUWRPLSCJUDFR-LURJTMIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(2-乙氧基苯基)哌嗪 、 (R)-1-(3-chloro-2-hydroxypropyl)-pyrrolidin-2-one 在 四丁基碘化铵 、 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 24.0h， 以80%的产率得到(S)-1-{3-[4-(2-ethoxyphenyl)piperazin-1-yl]-2-hydroxypropyl}-pyrrolidin-2-one
  参考文献：
  名称：

  Application of cyclic sulfates in the synthesis of enantiomers of 1-[3-(4-aryl-piperazin-1-yl)-2-hydroxy-propyl]-pyrrolidin-2-one

  摘要：

  The synthesis of enantiomers of 1-[3-(4-aryl-piperazin-1-yl)-2-hydroxy-propyl]-pyrrolidin-2-one derivatives is described. These enantiomers; were synthesized starting from (R)- or (S)-1-chloro-2,3-dihydroxypropane using relevant cyclic sulfates as chiral intermediates. The enantiomeric purities of the final compounds were in the range of 99.3-100.0%, as determined by high performance liquid chromatography. The final compounds were found to display moderate potency as ligands for alpha(1)-adrenoreceptors. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2009.01.029
• 作为产物：
  描述：

  2-吡咯烷酮 、 (R)-4-chloromethyl-1,3,2-dioxathiolane 2,2-dioxide 在 sodium hydride 、 硫酸 、 水 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以58%的产率得到(R)-1-(3-chloro-2-hydroxypropyl)-pyrrolidin-2-one
  参考文献：
  名称：

  Application of cyclic sulfates in the synthesis of enantiomers of 1-[3-(4-aryl-piperazin-1-yl)-2-hydroxy-propyl]-pyrrolidin-2-one

  摘要：

  The synthesis of enantiomers of 1-[3-(4-aryl-piperazin-1-yl)-2-hydroxy-propyl]-pyrrolidin-2-one derivatives is described. These enantiomers; were synthesized starting from (R)- or (S)-1-chloro-2,3-dihydroxypropane using relevant cyclic sulfates as chiral intermediates. The enantiomeric purities of the final compounds were in the range of 99.3-100.0%, as determined by high performance liquid chromatography. The final compounds were found to display moderate potency as ligands for alpha(1)-adrenoreceptors. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2009.01.029

文献信息

• Application of cyclic sulfates in the synthesis of enantiomers of 1-[3-(4-aryl-piperazin-1-yl)-2-hydroxy-propyl]-pyrrolidin-2-one
  作者：Katarzyna Kulig、Agnieszka Boba、Anna Bielejewska、Magdalena Gorska、Barbara Malawska

  DOI：10.1016/j.tetasy.2009.01.029

  日期：2009.2

  The synthesis of enantiomers of 1-[3-(4-aryl-piperazin-1-yl)-2-hydroxy-propyl]-pyrrolidin-2-one derivatives is described. These enantiomers; were synthesized starting from (R)- or (S)-1-chloro-2,3-dihydroxypropane using relevant cyclic sulfates as chiral intermediates. The enantiomeric purities of the final compounds were in the range of 99.3-100.0%, as determined by high performance liquid chromatography. The final compounds were found to display moderate potency as ligands for alpha(1)-adrenoreceptors. (C) 2009 Elsevier Ltd. All rights reserved.