2-methylsulfanyl-phenethyl alcohol | 102293-52-7

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2-methylsulfanyl-phenethyl alcohol
• 英文别名: 2-Methylmercapto-1-(2-hydroxy-aethyl)-benzol；Methyl-[2-(2-hydroxy-aethyl)-phenyl]-sulfid；1-(2-Methylmercapto-phenyl)-aethanol-(2)；2-Methylmercapto-phenaethylalkohol；2-(Methylthio)phenethyl alcohol；2-(2-methylsulfanylphenyl)ethanol
• CAS: 102293-52-7
• 化学式: C₉H₁₂OS
• 分子量: 168.26
• InChiKey: LWMYUPNRWLXJPD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  45.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-methylsulfanyl-phenethyl alcohol 在 双氧水 、 溶剂黄146 作用下， 生成 2-(2-(methylsulfonyl)phenyl)ethan-1-ol
  参考文献：
  名称：

  119.取代基对β-苯乙醇中羟基反应性的影响

  摘要：

  DOI：

  10.1039/jr9410000652
• 作为产物：
  描述：

  2-氨基苯乙醇 、 potassium ethyl xanthogenate 在 盐酸 作用下， 生成 2-methylsulfanyl-phenethyl alcohol
  参考文献：
  名称：

  119.取代基对β-苯乙醇中羟基反应性的影响

  摘要：

  DOI：

  10.1039/jr9410000652

文献信息

• Phenethanolamine compounds
  申请人：Glaxo Group Limited

  公开号：US04990505A1

  公开（公告）日：1991-02-05

  The invention provides compounds of the general formula (I) ##STR1## wherein the substituents are defined in the specification, and physiologically acceptable salts and solvates thereof. The compounds of formula (I) have a selective stimulant action at .beta..sub.2 -adrenoreceptors and are useful, in particular in the treatment of diseases associated with reversible airways obstruction such as asthma and chronic bronchitis.

  该发明提供了一般式(I)的化合物 ##STR1## 其中取代基在规范中定义，并且其生理上可接受的盐和溶剂化物。式(I)的化合物具有选择性刺激β2-肾上腺素能受体的作用，并且特别适用于治疗与可逆性气道阻塞相关的疾病，如哮喘和慢性支气管炎。
• POLYNUCLEOTIDE CONSTRUCTS HAVING DISULFIDE GROUPS
  申请人：BRADSHAW Curt W.

  公开号：US20160257961A1

  公开（公告）日：2016-09-08

  The invention features polynucleotide constructs containing one or more components (i) containing a disulfide linkage, where each of the one or more components is attached to an internucleotide bridging group or a terminal group of the polynucleotide construct, and each of the one or more components (i) contains one or more bulky groups proximal to the disulfide group. The invention also features polynucleotide constructs containing one or more components (i) containing a disulfide linkage, where each of the one or more components (i) is attached to an internucleotide bridging group or a terminal group of the polynucleotide construct, and each of the one or more components (i) contains at least 4 atoms in a chain between the disulfide linkage and the phosphorus atom of the internucleotide bridging group or the terminal group; and where the chain does not contain a phosphate, an amide, an ester, or an alkenylene. The invention also features methods of delivering a polynucleotide to a cell using the polynucleotide constructs of the invention.

  本发明涉及一种聚核苷酸构建物，其包含一个或多个组分（i），该组分包含一个二硫键，其中每个组分中的一个或多个组分连接到聚核苷酸构建物的核苷酸桥接基团或末端基团上，并且每个组分（i）在二硫键附近包含一个或多个笨重基团。本发明还涉及一种聚核苷酸构建物，其包含一个或多个组分（i），该组分包含一个二硫键，其中每个组分中的一个或多个组分连接到聚核苷酸构建物的核苷酸桥接基团或末端基团上，并且每个组分（i）在二硫键和核苷酸桥接基团或末端基团的磷原子之间的链中至少含有4个原子；并且链中不含有磷酸盐、酰胺、酯或烯基烃。本发明还涉及使用本发明的聚核苷酸构建物向细胞传递聚核苷酸的方法。
• POLYNUCLEOTIDE CONSTRUCTS HAVING BIOREVERSIBLE AND NON-BIOREVERSIBLE GROUPS
  申请人：BRADSHAW Curt W.

  公开号：US20170114341A1

  公开（公告）日：2017-04-27

  The invention features a hybridized polynucleotide construct containing a passenger strand, a guide strand loadable into a RISC complex, and (i) a 3′-terminal or an internucleotide non-bioreversible group in the guide strand; or (ii) a 5′-terminal, a 3′-terminal, or an internucleotide non-bioreversible group in the passenger strand, and a 5′-terminal, a 3′-terminal, or an internucleotide disulfide bioreversible group in the guide strand or the passenger strand. The invention also features methods of delivering a polynucleotide to a cell using the hybridized polynucleotide construct. The invention further features methods of reducing the expression of a polypeptide in a cell using the hybridized polynucleotide construct.
• US4518596A
  申请人：——

  公开号：US4518596A

  公开（公告）日：1985-05-21
• US4690923A
  申请人：——

  公开号：US4690923A

  公开（公告）日：1987-09-01