4-Phenyl-6-methyl-chinazolinon | 13961-64-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-Phenyl-6-methyl-chinazolinon
• 英文别名: 6-methyl-4-phenyl-1H-quinazolin-2-one；6-Methyl-4-phenyl-1H-chinazolin-2-on；4-Phenyl-6-methyl-2(1H)-quinazolinone；6-methyl-4-phenylquinazolin-2(1H)-one；6-methyl-4-phenyl-1H-quinazolin-2-one
• CAS: 13961-64-3
• 化学式: C₁₅H₁₂N₂O
• 分子量: 236.273
• InChiKey: ULRSRGDZNASHQP-UHFFFAOYSA-N

物化性质

• 熔点：
  286-287 °C(Solv: N,N-dimethylformamide (68-12-2))
• 密度：
  1.21±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  41.5
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2933990090

反应信息

• 作为反应物：
  描述：

  4-Phenyl-6-methyl-chinazolinon 在 C₃₄H₃₃O₄P 、 1,4-二氢-2,6-二甲基吡啶-3,5-二羧酸二甲酯 作用下， 反应 12.0h， 以92%的产率得到(R)-6-methyl-4-phenyl-3,4-dihydroquinazolin-2(1H)-one
  参考文献：
  名称：

  手性磷酸催化喹唑啉酮的不对称转移氢化

  摘要：

  DOI：

  10.1016/j.tetlet.2019.150947
• 作为产物：
  描述：

  苯甲酰氯 在 zinc(II) chloride 作用下， 生成 4-Phenyl-6-methyl-chinazolinon
  参考文献：
  名称：

  Hanschke, Chemische Berichte, 1899, vol. 32, p. 2026

  摘要：

  DOI：

文献信息

• Biomimetic Asymmetric Reduction of Quinazolinones with Chiral and Regenerable<scp>NAD</scp>(P)H Models
  作者：Zi‐Biao Zhao、Xiang Li、Bo Wu、Yong‐Gui Zhou

  DOI：10.1002/cjoc.202000045

  日期：2020.7

  A facile approach to chiral dihydroquinazolinone derivatives has been described via biomimetic asymmetric reduction of quinazolinones with chiral and regenerable NAD(P)H models. The utility of this method was demonstrated by a concise synthesis of the bromodomain protein divalent inhibitor.

  通过手性和可再生的NAD（P）H模型通过仿生不对称还原喹唑啉酮，已经描述了一种简便的手性二氢喹唑啉酮衍生物的方法。溴结构域蛋白二价抑制剂的简明合成证明了该方法的实用性。
• [EN] 4-ARYLQUINAZOLINE DERIVATIVES AS METHIONINE ADENOSYLTRANSFERASE 2A INHIBITORS<br/>[FR] DÉRIVÉS DE 4-ARYLQUINAZOLINE EN TANT QU'INHIBITEURS DE LA MÉTHIONINE ADÉNOSYLTRANSFÉRASE 2A
  申请人：IDEAYA BIOSCIENCES INC

  公开号：WO2021252680A1

  公开（公告）日：2021-12-16

  Disclosed herein are certain 4-arylquinazoline derivatives of Formula (I) that are methionine adenosyltransferase 2A (MAT2A) inhibitors. Also disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of MAT2A such as cancer, including cancers characterized by reduced or absence of methylthioadenosine phosphorylase (MTAP) activity.

  本文披露了某些Formula (I)的4-芳基喹唑啉衍生物，它们是蛋氨酸腺苷转移酶2A（MAT2A）抑制剂。还披露了包含这些化合物的药物组合物以及治疗MAT2A抑制剂可治疗的疾病的方法，如癌症，包括特征为甲硫腺苷磷酸化酶（MTAP）活性降低或缺失的癌症。
• AGENT FOR INHIBITING CYTOKININ SIGNALING
  申请人：Nagasawa Asako

  公开号：US20100056377A1

  公开（公告）日：2010-03-04

  Disclosed are: a substance which has an activity of inhibiting the intracellular signaling from a plant-derived cytokinin receptor and which can control the growth or differentiation of a plant. Also, disclose is a method for searching for a chemical substance capable of promoting the growth of a root of a plant, which comprises measuring the level of intracellular signaling from the receptor in a system where a cell having the receptor is contacted with a chemical substance having an agonistic activity on the receptor and a substance to be tested, comparing the level of intracellular signaling measured in the preceding step with a level of intracellular signaling measured in the absence of the chemical substance, and determining the chemical substance as being a chemical substance capable of promoting the growth of a root of a plant based on the difference obtained by the comparison; and others.

  本发明涉及一种具有抑制植物来源细胞因子受体内部信号传递活性的物质，可控制植物的生长或分化。同时，还揭示了一种搜寻促进植物根生长的化学物质的方法，其中包括测量具有激动剂活性的化学物质与待测试物质接触的受体细胞系统中的细胞内信号传递水平，将前一步骤中测量的细胞内信号传递水平与无化学物质存在时测量的细胞内信号传递水平进行比较，并根据所得到的差异确定该化学物质为能够促进植物根生长的化学物质。
• BOGATSKIJ A. V.; ANDRONATI S. A.; ZHILINA Z. I.; DANILINA N. I., ZH. ORGAN. XIMII, 1977, 13, HO 8,
  作者：BOGATSKIJ A. V.、 ANDRONATI S. A.、 ZHILINA Z. I.、 DANILINA N. I.

  DOI：——

  日期：——
• YAMAMOTO M.; INABA S.; YAMAMOTO H., CHEM. AND PHARM. BULL., 1978, 26, NO 6, 1633-1651
  作者：YAMAMOTO M.、 INABA S.、 YAMAMOTO H.

  DOI：——

  日期：——