N-[4-chloro-2-(N-ethoxy-C-methylcarbonimidoyl)phenyl]-1,1,1-trifluoromethanesulfonamide | 880471-43-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[4-chloro-2-(N-ethoxy-C-methylcarbonimidoyl)phenyl]-1,1,1-trifluoromethanesulfonamide
• CAS: 880471-43-2
• 化学式: C₁₁H₁₂ClF₃N₂O₃S
• 分子量: 344.742
• InChiKey: PZRMFJPLDAYYQH-UHFFFAOYSA-N

物化性质

• 沸点：
  365.8±52.0 °C(Predicted)
• 密度：
  1.44±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  76.1
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  N-(2-acetyl-4-chlorophenyl)trifluoromethanesulfonamide 、 乙氧基胺盐酸盐 在 sodium acetate 作用下， 以 乙醇 为溶剂， 生成 N-[4-chloro-2-(N-ethoxy-C-methylcarbonimidoyl)phenyl]-1,1,1-trifluoromethanesulfonamide
  参考文献：
  名称：

  Parasiticidal 2-alkoxy- and 2-aryloxyiminoalkyl trifluoromethanesulfonanilides

  摘要：

  A series of novel 2-alkoxy- and 2-aryloxyiminoalkyl trifluoromethanesulfonanilide derivatives have shown significant in vitro parasiticidal activity against the ectoparasites Ctenocephalides felis and Rhipicephalus sanguineus. A number of these compounds also displayed significant in vitro endoparasite activity against the nematode Haemonchus contortus. Crown copyright (C) 2007 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.10.090

文献信息

• Parasiticidal 2-alkoxy- and 2-aryloxyiminoalkyl trifluoromethanesulfonanilides
  作者：Abdelselam Ali、Timothy M. Altamore、Marianne Bliese、Petr Fisara、Andris J. Liepa、Adam G. Meyer、Oahn Nguyen、Roger M. Sargent、David G. Sawutz、David A. Winkler、Kevin N. Winzenberg、Angela Ziebell

  DOI：10.1016/j.bmcl.2007.10.090

  日期：2008.1

  A series of novel 2-alkoxy- and 2-aryloxyiminoalkyl trifluoromethanesulfonanilide derivatives have shown significant in vitro parasiticidal activity against the ectoparasites Ctenocephalides felis and Rhipicephalus sanguineus. A number of these compounds also displayed significant in vitro endoparasite activity against the nematode Haemonchus contortus. Crown copyright (C) 2007 Published by Elsevier Ltd. All rights reserved.