4-chloro-N-[(4-methoxyphenyl)-morpholin-4-ylmethyl]benzamide | 1257405-22-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-chloro-N-[(4-methoxyphenyl)-morpholin-4-ylmethyl]benzamide
• CAS: 1257405-22-3
• 化学式: C₁₉H₂₁ClN₂O₃
• 分子量: 360.84
• InChiKey: JTAFHJMBSUCOJF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  50.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-(dimorpholinomethyl)-1-methoxybenzene 、 4-氯苯甲酰胺 反应 0.12h， 以65%的产率得到4-chloro-N-[(4-methoxyphenyl)-morpholin-4-ylmethyl]benzamide
  参考文献：
  名称：

  Solvent-free synthesis of monoacylaminals from the reaction of amides and aminals as precursors in carbinolamide synthesis

  摘要：

  A solvent-free method of generating monoacylaminals by heating the amide and aminal starting materials in the presence of one another has been developed. Yields were generally between 45% and 65% with the monoacylaminal being isolated, needing no further purification after drying under high vacuum. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.09.043

文献信息

• Solvent-free synthesis of monoacylaminals from the reaction of amides and aminals as precursors in carbinolamide synthesis
  作者：Matthew F. Sansone、Takaoki Koyanagi、David E. Przybyla、Richard W. Nagorski

  DOI：10.1016/j.tetlet.2010.09.043

  日期：2010.11

  A solvent-free method of generating monoacylaminals by heating the amide and aminal starting materials in the presence of one another has been developed. Yields were generally between 45% and 65% with the monoacylaminal being isolated, needing no further purification after drying under high vacuum. (C) 2010 Elsevier Ltd. All rights reserved.