4-aminomethyl-pyridine-2,6-diamine | 437652-65-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-aminomethyl-pyridine-2,6-diamine
• 英文别名: 4-(Aminomethyl)pyridine-2,6-diamine
• CAS: 437652-65-8
• 化学式: C₆H₁₀N₄
• mdl: MFCD19214480
• 分子量: 138.172
• InChiKey: MILKFNKSBVDQAW-UHFFFAOYSA-N

物化性质

• 沸点：
  387.3±37.0 °C(Predicted)
• 密度：
  1.288±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.166
• 拓扑面积：
  91
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  环戊基甲酰氯 、 4-aminomethyl-pyridine-2,6-diamine 在 4-二甲氨基吡啶 silica 、 methanol-dichloromethane 作用下， 以 吡啶 为溶剂， 反应 2.5h， 以to yield 93 mg (26%) of the title compound的产率得到cyclopentanecarboxylic acid (2,6-diamino-pyridin-4-ylmethyl)-amide
  参考文献：
  名称：

  Substituted [1,2,4]triazolo[1,5a]pyridine derivatives with activity as adenosine receptor ligands

  摘要：

  本文披露了替代的[1,2,4]三唑[1,5a]吡啶衍生物及其在药物上活性的盐，具有作为腺苷受体配体的活性。这些化合物可用于治疗对腺苷受体调节有反应的疾病。

  公开号：

  US06506772B1
• 作为产物：
  描述：

  2,6-diaminopyridine-4-carboxylic acid methyl ester 在 盐酸 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 生成 4-aminomethyl-pyridine-2,6-diamine
  参考文献：
  名称：

  Substituted [1,2,4]triazolo[1,5a]pyridine derivatives with activity as adenosine receptor ligands

  摘要：

  本文介绍了具有腺苷受体配体活性的取代的[1,2,4]三唑并[1,5a]吡啶衍生物及其药物活性盐。这些化合物可用于治疗对腺苷受体调节敏感的疾病。

  公开号：

  US06506772B1

文献信息

• [EN] DERIVATIVES OF 2-[2-(BENZO- OR PYRIDO-) THIAZOLYLAMINO]-6-AMINOPYRIDINE, USEFUL IN THE TREATMENT OF RESPIRATORIC, ALLERGIC OR INFLAMMATORY DISEASES<br/>[FR] DÉRIVÉS DE 2-[2-(BENZO- OU PYRIDO-)THIAZOLYLAMINO]-6- AMINOPYRIDINE, UTILES DANS LE TRAITEMENT DE MALADIES RESPIRATOIRES, ALLERGIQUES OU INFLAMMATOIRES
  申请人：GLAXO GROUP LTD

  公开号：WO2011110575A1

  公开（公告）日：2011-09-15

  The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular Itk activity.

  本发明涉及某些新型化合物。具体而言，本发明涉及通式（I）的化合物及其盐。本发明的化合物是激酶活性的抑制剂，特别是Itk活性的抑制剂。
• AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS
  申请人：F. HOFFMANN-LA ROCHE AG

  公开号：EP1347974A1

  公开（公告）日：2003-10-01
• US6506772B1
  申请人：——

  公开号：US6506772B1

  公开（公告）日：2003-01-14
• [EN] AMINOTRIAZOLOPYRIDIINE DERIVATIVES AS ADENOSINE RECEPTOR LIGANDS<br/>[FR] DERIVES D'AMINOTRIAZOLOPYRIDINE EN TANT QUE LIGANDS DU RECEPTEUR D'ADENOSINE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2002048145A1

  公开（公告）日：2002-06-20

  The invention relates to compounds of the general formula (I) wherein R1 is lower alkoxy, cycloalkyl or aryl, unsubstituted or substituted by halogen or lower alkoxy or is NR'R'', wherein R' and R'' are independently from each other hydrogen, lower alkyl, lower alkenyl, lower alkinyl, -(CR¿2?)n-aryl unsubstituted or substituted by one to three substituents, selected from the group, consisting of halogen or lower alkoxy, or are (CH2)n+1NR2, -(CH2)n-pyridinyl, -(CH2)n-indanyl, -(CH2)n-cycloalkyl, -(CH2)n-O-lower alkyl, -(CH2)n-C(O)-NR2, -(CH2)n-CF3, OR R' and R'' are together with the N atom to which they are attached pyrrolidin-1-yl, piperidin-1-yl, 3,4-dihydro-1H-isoquinolin-2-yl, morpholinyl, azatidin-1-yl, 3,6-dihydro-2H-pyridin-1-yl, thiomorpholinyl, 2,5-dihydro-pyrrol-1-yl, thiazolidin-3-yl, piperazinyl, azocan-1-yl, azepan-1-yl, octahydroquinolin-1-yl, octahydroquinolin-2-yl, 1,3,4,9-tetrahydro-b-carbolin-2-yl, which rings may be unsubstituted or substituted by one to three substituents, selected from the group, consisting of lower alkyl, phenyl, benzyl, pyridyl, -C(O)-NR2, -(CH2)n-O-lower alkyl or NR-C(O)-lower alkyl; R?2¿ is aryl or a 5 or 6 membered heteroaryl group, which rings are unsubstituted or substituted by lower alkyl, halogen, hydroxy or lower alkoxy; X is a bond or N(R)CH¿2?-; R is hydrogen or lower alkyl; N is 0,1,2,3,4,5 or 6; and to their pharmaceutically acceptable salts. The compounds have a good affinity to the adenosin receptor and may therefore be used in the treatment of diseases, related to this receptor.
• Substituted &lsqb;1,2,4&rsqb;triazolo&lsqb;1,5a&rsqb;pyridine derivatives with activity as adenosine receptor ligands
  申请人：Hoffmann-La Roche Inc.

  公开号：US06506772B1

  公开（公告）日：2003-01-14

  Substituted [1,2,4]triazolo[1,5a]pyridine derivatives and pharmaceutically active salts thereof with activity as adenosine receptor ligands are disclosed. These compounds are useful for treatment of diseases responsive to modulation of the adenosine receptor.

  本文介绍了具有腺苷受体配体活性的取代的[1,2,4]三唑并[1,5a]吡啶衍生物及其药物活性盐。这些化合物可用于治疗对腺苷受体调节敏感的疾病。