Amino acid bridged dicatechol ligands 1 a - e are synthesized by a stepwise coupling procedure. First 2,3-dimethoxybenzoic acid (2) is coupled with the amino acid (3 a - e) followed by a second coupling step of the obtained derivatives 4 a - e with 2,3-dimethoxybenzyl amine (5). As coupling reagents for the amide bonds either DDC/NHS or EDC/HOBt are used. In the final step of the reaction sequence the methyl ethers of the ligand precursors 6 a - e are potential building blocks for metallo-supramolecular chemistry.
氨基酸桥接的二
桂醇配体1 a - e是通过逐步耦合程序合成的。首先将
2,3-二甲氧基苯甲酸(2)与
氨基酸(3 a - e)耦合,随后将所得衍
生物4 a - e与2,3-二
甲氧基苯甲胺(5)进行第二次耦合。在酰胺键的耦合试剂中,使用了DDC/NHS或EDC/
HOBt。在反应序列的最后一步,
配体前驱体6 a - e的甲基醚是
金属超分子
化学的潜在构建块。