N-[(1,1'-biphenyl-4-yl)(phenyl)methyl]-4-methylbenzenesulfonamide | 1032582-94-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-[(1,1'-biphenyl-4-yl)(phenyl)methyl]-4-methylbenzenesulfonamide
• 英文别名: 4-methyl-N-[phenyl-(4-phenylphenyl)methyl]benzenesulfonamide
• CAS: 1032582-94-7
• 化学式: C₂₆H₂₃NO₂S
• 分子量: 413.54
• InChiKey: IKLWTTZALPGBBH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-亚苄基-4-甲基苯磺酰胺 、 4-联苯硼酸 在 2,2'-联吡啶 、 palladium diacetate 作用下， 以 1,4-二氧六环 为溶剂， 生成 N-[(1,1'-biphenyl-4-yl)(phenyl)methyl]-4-methylbenzenesulfonamide
  参考文献：
  名称：

  Catalytic Enantioselective Arylation of N-Tosylarylimines with Arylboronic Acids Using C₂-Symmetric Cationic N-Heterocyclic Carbene Pd²⁺ Diaquo Complexes

  摘要：

  The asymmetric arylation of N-tosylimines with arylboronic acids was realized by using chiral cationic C-2-symmetric N-heterocyclic carbene (NHC) Pd2+ diaquo complex 5b as the catalyst in combination with 1.0 equiv of K3PO4 center dot 3H(2)O in THF at 4 degrees C in the presence of powdered 4 angstrom MS to afford the corresponding adducts in excellent yields (up to 99%) and good to high enantioselectivities (up to 94% ee).

  DOI：

  10.1021/ol802861s

文献信息

• <i>α</i>‐C−H Arylation of <i>N</i>‐Sulfonyl Amines by Dual Palladium Catalysis
  作者：Yu‐Cheng Liu、Hang Shi

  DOI：10.1002/cctc.202300392

  日期：2023.6.9

  α-arylated amines from simple linear N-sulfonyl amines and aryl boroxines utilizing dual palladium catalysis involving amine dehydrogenation. Bromobenzene serves as a hydride acceptor, and the ensuing imine intermediate undergoes a novel umpolung arylation. Given the wide availability of primary amines, this method can be expected to be useful for the synthesis of structurally complex amines with varied

  介绍了一种可靠的方法，利用双钯催化涉及胺脱氢，从简单的线性N-磺酰胺和芳基环硼氧烷合成支链 α-芳基化胺。溴苯作为氢化物受体，随后的亚胺中间体进行新的 umpolung 芳基化。鉴于伯胺的广泛可用性，这种方法有望用于合成具有不同功能的结构复杂的胺。